Navigation Links
Building 'smart' cell-based therapies
Date:4/17/2014

erent biosensors can be present in a single cell without interfering with one another, allowing bioengineers to build increasingly sophisticated functional programs. The platform is also highly modular, enabling the biosensors to be customized to recognize factors of relevance to various patients' needs.

"By linking the output of these biosensors to genetic programs, one can build in a certain logical command, such as 'turn the output gene on when you sense this factor but not that factor,'" Leonard explains. "In that way, you could program a cell-based therapy to specify which cells it should kill."

Leonard says doctors could potentially collect immune cells from a patient's body, engineer the cells using MESA, and put them back into the patient. From there, the cells would do the work of detecting cancer or the disease they are designed to identify.

This is the first completely ground-up engineering of a receptor, and now that the core technology has been established, Leonard's team is moving forward to program cells to recognize specific tumor-associated factors. They are also looking toward applications beyond advanced cell-based therapies.

"This seems to be what always happens in synthetic biology," he says. "When you start building something, you first learn a lot about the system that you are trying to modify. In the end, you come up with not only useful applications but tools that facilitate basic science."


'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Body Building, Diet Supplements Linked to Liver Damage: Study
2. Germ Culprits in Moldy, Water-Damaged Buildings Identified
3. Building a better Rift Valley fever vaccine
4. Heuer M.D. Research Announces CardiaShred™ - First Medical Doctor Formulated, Heart Healthy Weight Loss, Energy and Lean Muscle Building Supplement
5. Kessler Foundation presents Brain Injury: From Research to Rebuilding Lives on Sept. 27-28
6. Rebuilding a whole heart for children born with only half of 1
7. UC research explores relationship-building program for male same-sex couples
8. Dental Marketing Formula.com has been Featured in The LA Daily News for their Specialized Practice Building Solutions in the Dental Industry
9. Steering stem cells to become 2 different building blocks for new blood vessels
10. Rebuilding blood vessels through gene therapy
11. Visual Impact Muscle Building: Review Examining Rusty Moore's Training Program Released By DietsAndFitnessGuides.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 With most forms ... sense to use hearing protection when exposed to ... are many different forms of hearing protection ... provide hearing protection training and devices for workers ... industries. The National Institute of Occupational Safety and ...
(Date:8/27/2014)... time you experienced worrisome medical symptoms, did you ... professional? If so, you,re not alone. Consumers are ... support groups to gather anecdotal information and advice, ... trustworthy sources. New research to be presented at ... the characteristics of consumers who use the Internet ...
(Date:8/27/2014)... 27, 2014 (HealthDay News) -- A new genetic discovery ... fight the bowel disorder, researchers report. The ... affect how their genes work, and said these changes ... raising the possibility of a simple diagnostic test for ... disease develops and suggest possible gene targets for new ...
(Date:8/27/2014)... An experimental drug designed to help regulate the blood,s iron ... of inflammation, according to results from the first human ... Blood , the Journal of the American ... occurs when red blood cells are in short supply or ... body does not get enough oxygen, since there are fewer ...
(Date:8/27/2014)... 8/27/14)Dartmouth cancer researchers developed and tested an advanced ... interactions that contribute to disease as published yesterday ... The approach fills a gap in current analyses. ... interactions among genetic and environmental factors. When many ... versus those that reflect chance combinations among affected ...
Breaking Medicine News(10 mins):Health News:Hearing Health Solutions Now Offering a Full Line of Occupation Hearing Protection Services and Expanded Line of Ear Protection Products 2Health News:Hearing Health Solutions Now Offering a Full Line of Occupation Hearing Protection Services and Expanded Line of Ear Protection Products 3Health News:Educated consumers more likely to use potentially unreliable online healthcare information 2Health News:Scientists Spot Genetic Clues to Crohn's Disease 2Health News:Drug represents first potential treatment for common anemia 2Health News:Dartmouth isolates environmental influences in genome-wide association studies 2
... may lower the risk of a type of kidney malignancy ... ,The researchers at Brigham and Women's Hospital in Boston found ... alcoholic beverage a day were about 30 percent less likely ... they found in people who drank beer, wine or liquor. ...
... US President set a target of ten years for developing ... ,"We have learned in that period of time ... senior vice president for research and development at the International ... vaccine research increased from $186 million in 1997 to $759 ...
... rates among Japanese have generally tended to be high. Now ... hit a record 65 in 2006, compared to 42 ... ,The number of workers who received compensation for work-induced ... percent from a year earlier, he said. The number of ...
... of Health and Child Welfare, Dr. David Parirenyatwa, says ... West have severely compromised the country's health delivery ... ongoing World Health Assembly in Geneva, Switzerland, to join ... these sanctions. He calls the sanctions an unacceptable ...
... have agreed on a $5-billion initiative with major banks to ... the first such enterprise to combat climate change. ... this week with a summit in New York attended by ... to discuss climate change. ,Clinton's initiative launched on ...
... developed a model that could improve the treatment ... combine current clot-busting medication with below-normal body temperatures ... lowering a patients temperature reduces the metabolic activity ... cell damage and death. ,The FDA-approved ...
Cached Medicine News:Health News:AIDS Vaccine Still a Long Way Off 2Health News:Workplace Stress Leads to Rising Suicide Rate in Japan 2Health News:Sanctions Imposed On Zimbabwe Can Threaten International Health Security 2Health News:World Cities Join Hands to Combat Climate Change 2Health News:Researchers Develop Model That Aids in Treating Stroke Patients 2
(Date:8/27/2014)... , August 27, 2014 ... Equipment Market By Products (Dental Radiology, CAD/CAM, Dental Chairs, Dental ... published by MarketsandMarkets, the global Dental Equipment Market is ... $5,416.3 million in 2014, growing at a CAGR ... Browse 95 market data tables and 61 figures ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces that ... its catalogue: Global Heart Valve Repair ... http://www.reportlinker.com/p02316644/Global-Heart-Valve-Repair-and-Replacement-Market-2014-2018.html About Heart Valve Repair ... human heart which control the flow of blood ... heart valve diseases such as valvular stenosis, valvular ...
(Date:8/27/2014)... 27, 2014  Hill-Rom Holdings, Inc. (NYSE: ... presentation at the Morgan Stanley Global Healthcare Conference on ... You are invited to listen to the live discussion ... access it directly at http://cc.talkpoint.com/morg007/090814a_ac/?entity=26_7CLOGQP .  A recorded ... after conclusion of the live event and accessible at ...
Breaking Medicine Technology:Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: