Navigation Links
Building 'smart' cell-based therapies
Date:4/17/2014

A Northwestern University synthetic biology team has created a new technology for modifying human cells to create programmable therapeutics that could travel the body and selectively target cancer and other sites of disease.

Engineering cell-based, biological devices that monitor and modify human physiology is a promising frontier in clinical synthetic biology. However, no existing technology enabled bioengineers to build such devices that sense a patient's physiological state and respond in a customized fashion.

"The project addressed a key gap in the synthetic biology toolbox," says Joshua Leonard, assistant professor of chemical and biological engineering in Northwestern's McCormick School of Engineering and Applied Science. "There was no way to engineer cells in a manner that allowed them to sense key pieces of information about their environment, which could indicate whether the engineered cell is in healthy tissue or sitting next to a tumor."

Funded by the National Academies Keck Futures Initiative and the Defense Advanced Research Projects Agency, the research is available to read online in the journal ACS Synthetic Biology.

Leonard's team worked for nearly four years to close this gap. The end result is a protein biosensor that sits on the surface of a cell and can be programmed to sense specific external factors. For example, the engineered cell could detect big, soluble protein molecules that indicate that it's next to a tumor. When the biosensor detects such a factor, it sends a signal into the engineered cell's nucleus to activate a gene expression program, such as the production of tumor-killing proteins or chemicals. Since this toxic program would be activated only near tumor cells, such an approach could minimize side effects as well as improve therapeutic benefits.

Called a Modular Extracellular Sensor Architecture (MESA), the biosensor platform is completely self-contained so that several diff
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Body Building, Diet Supplements Linked to Liver Damage: Study
2. Germ Culprits in Moldy, Water-Damaged Buildings Identified
3. Building a better Rift Valley fever vaccine
4. Heuer M.D. Research Announces CardiaShred™ - First Medical Doctor Formulated, Heart Healthy Weight Loss, Energy and Lean Muscle Building Supplement
5. Kessler Foundation presents Brain Injury: From Research to Rebuilding Lives on Sept. 27-28
6. Rebuilding a whole heart for children born with only half of 1
7. UC research explores relationship-building program for male same-sex couples
8. Dental Marketing Formula.com has been Featured in The LA Daily News for their Specialized Practice Building Solutions in the Dental Industry
9. Steering stem cells to become 2 different building blocks for new blood vessels
10. Rebuilding blood vessels through gene therapy
11. Visual Impact Muscle Building: Review Examining Rusty Moore's Training Program Released By DietsAndFitnessGuides.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Although most people are aware of the need ... is particularly important for women. Changes to hormone levels ... ways. Hormones can affect the blood supply to the ... receive nutrients essential to fight infection. In addition, changing ... produced by plaque bacteria, increasing the risk of inflammation ...
(Date:8/1/2014)... 02, 2014 The successful development of ... business of Guangdong FODAY Automobile Co.,LTD. As early as ... had already organized an excellent team to develop a ... detailed, in-depth technical plans. The company’s vice president Liming ... the direct involvement of the specific arrangement and the ...
(Date:8/1/2014)... Recently, iFitDress.com, one of the most famous dress suppliers ... top bridesmaid dresses online. At the moment, all the ... 52% off. According to the company’s senior spokesman, the special ... The company’s stock is limited. Those who are thinking of ... soon as possible. All its products are delicately made by ...
(Date:8/1/2014)... August 01, 2014 Cannabis use among young ... aged 14 to 17 having used marijuana at least once ... their slogan “Say ‘No’ to Drugs, Say ‘Yes to Life,’ ... out to youth this summer with factual information about drugs, ... six months, Hamburg “Say ‘No’ to Drugs, Say ‘Yes’ to ...
(Date:8/1/2014)... The Judicial Panel on Multidistrict Litigation (JPML) issued ... strokes, heart attacks, and other injuries in men who ... as the transferee judge and ordered what could be ... , As one of his first organizing acts, Judge ... who will move the litigation forward on behalf of ...
Breaking Medicine News(10 mins):Health News:Midtown Dentistry Renews Call for Women to Look After Their Dental Health 2Health News:FODAY Automobile Company Is Now Working On The C60F FODAY Project 2Health News:iFitDress.com: Top Bridesmaid Dresses For The Global Customers 2Health News:Addressing a Serious Issue Affecting German Teens 2Health News:Judge Kennelly Appoints Attorney Michelle Kranz to the Plaintiffs’ Executive Committee in the Testosterone Replacement Therapy MDL 2
... Dr. Hungerford is ... invasive single as well as double hip replacement procedures. , ... (Vocus) June 29, 2009 -- Noted orthopedic surgeon Marc ... hospital,s Medical Director of Joint Replacement and Reconstruction, Dr. Thomas Whitten, Chief of Orthopedics at ...
... the victims of these falls, CDC says , MONDAY, ... 47,000 elderly Americans are treated at hospital emergency departments ... according to a federal government study released Monday. , ... day. , U.S. Centers for Disease Control and Prevention ...
... the 1600s quinine was the first effective treatment in the ... commonly used treatment against this devastating disease. But the drug ... can range from sickness and headaches to blindness, deafness and ... knew why. Scientists at The University of Nottingham have ...
... emergency departments first sites for savings ... CalRHIO announced today that it has selected the RAND ... measure savings resulting from physicians having secure electronic access to ... The first phase of the initiative will measure savings in ...
... N.C., June 29 Carolinas HealthCare System ... growth and development of cardiovascular services in North and South ... Sanger Heart and Vascular Institute (SHVI) represents a ... and Vascular Institute. The Institute will continue serving as a ...
... Medicaid Funding Boost Merely Scratches Surface in Terms of Meeting ... In summing up the 2009 session of the Texas ... by Governor Rick Perry, the Texas Health Care Association (THCA) ... ($60 million general revenue) for Medicaid-financed nursing home care, substantially ...
Cached Medicine News:Health News:Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center 2Health News:Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center 3Health News:47,000 Elderly Hurt in Walker, Cane Mishaps Each Year 2Health News:Breakthrough in combating the side effects of quinine 2Health News:CalRHIO Selects RAND-USC to Evaluate Savings Resulting from Use of Statewide Health Information Exchange 2Health News:CalRHIO Selects RAND-USC to Evaluate Savings Resulting from Use of Statewide Health Information Exchange 3Health News:Sanger Clinic Lends Its Name to New Heart Care Institute Serving NC and SC 2Health News:THCA on 2009 Legislative Session: Seniors' Medicaid-Financed Nursing Home Care Requires Substantially More Investment as Population Ages, Care Needs Grow 2
(Date:8/1/2014)... 1, 2014  PTC Therapeutics, Inc. (NASDAQ: ... it approved non-statutory stock options to purchase an aggregate ... new employees. The awards were made pursuant to the ... new hires, employment compensation. The inducement grants ... 2014 and are being made as an inducement material ...
(Date:8/1/2014)... 2014  With monumental health reform coming into effect, ... language. Clinical efficacy is no longer the sole driver ... like PCORI are directing roughly $1 billion a year ... and environments, the federal healthcare ecosystem is changing, and ... outcomes and managed markets to the right people in ...
(Date:8/1/2014)... LAVAL, Quebec and NEW YORK ... Inc. (NYSE/TSX: VRX) and Pershing Square Capital Management, L.P. ... by Allergan, Inc. (NYSE: AGN ) in ... Pershing Square regarding the tender offer rules.  ... an attempt to interfere with shareholders, efforts to call ...
Breaking Medicine Technology:PTC Therapeutics Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) 2Pharmaceuticals Learning the Language of the New Healthcare Landscape 2Pharmaceuticals Learning the Language of the New Healthcare Landscape 3Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 2Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 3Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 4Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 5Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 6
... Reportlinker.com announces that a new market research ... Insulin- Western Europe ... package contains 14 insulin market analyses from ... Denmark, Finland, France, Germany, Ireland, Italy, the ...
... Calif., July 31, 2011 Accuray Incorporated ... radiation oncology company, announced today that it will showcase ... TomoTherapy® Radiation Therapy Treatment System in the ... Association of Physicists in Medicine (AAPM)/Canadian Organization of Medical ...
Cached Medicine Technology:Insulin- Western Europe 2Accuray Symposium Puts Spotlight on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 2Accuray Symposium Puts Spotlight on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 3Accuray Symposium Puts Spotlight on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 4
... For Excellent Drainage PLUS Greater Patient ... BLAKE Drains are white, radiopaque silicone drains ... a solid core center. Their other components ... extension tubing and an adapter. The drains ...
Used for percutaneous placement of laparoscopic surgical instruments. Check-Flo® valve provides a secure seal around the instruments to be introduced. Supplied sterile in peel-open packages. Inte...
Used for internal biliary drainage. Supplied sterile in peel-open packages. Intended for one-time use....
Used for common bile duct exploration. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: