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Bug guts map brings scientists closer to understanding different bugs' role in the body
Date:2/5/2008

Scientists have made a major step towards understanding precisely which bugs in the gut are involved in which processes in the body, by mapping the different species of bugs living in seven members of the same Chinese family.

Bugs in the gut are known as gut microbes and trillions live symbiotically inside the human body. Different people can have very different populations of gut microbes living inside them.

The makeup of each persons gut microflora influences their health, and abnormalities in gut microbes have been linked to diseases such as diabetes and obesity.

Research has already shown that the makeup of an individual's gut microbes is can be changed by their diet and other environmental factors. Scientists are hopeful that many diseases could be tackled by creating drugs that target different gut bugs and correct abnormalities in them.

However, although it is known that gut bugs are involved in many of the bodys processes, the relationship between different species of bug and different processes has previously been defined only at a broad level, mainly concentrating on the metabolism of fat.

This is partly because it is difficult to observe the interactions inside a living human body in such microscopic detail. Mapping the species of gut microflora inside a person requires DNA fingerprinting of the bugs and detailed analysis is extremely complex and expensive. Prior to the new study, only five people in the world had ever had their gut microflora profiled in depth and had these data published.

The new study is a major step towards fully defining how different gut bugs affect the metabolism the chemical reactions inside the body that keep it working, for example in converting food into energy or in maintaining cells.

The researchers believe that once they have a complete map of the interactions between the bugs and the metabolism, they will be able to use metabolic information to determi
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Contact: Abigail Smith
abigail.smith@imperial.ac.uk
44-020-759-46701
Imperial College London
Source:Eurekalert

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