Navigation Links
Bryan Roth honored for excellence in clinical pharmacology
Date:3/24/2011

CHAPEL HILL, N.C. - Bryan L. Roth, PhD, the Michael J. Hooker Distinguished Professor of Pharmacology in the University of North Carolina at Chapel Hill School of Medicine, has received the PhRMA Foundation Award in Excellence in Pharmacology/Toxicology.

Roth is also professor in the departments of pharmacology, medicinal chemistry and natural products and he holds the Michael Hooker Chair of Protein Therapeutics and Translational Proteomics.

His work in pharmacology and drug discovery has earned him numerous patents and he has published nearly 300 articles in, among many other publications, Science, Nature, Cell and the New England Journal of Medicine. He has also trained dozens of doctoral and post-doctoral students who have also become leaders in their field.

Much of Roth's research focuses on trying to understand how central nervous system drugs affect the brain's neurons. The goal is to investigate existing treatments in order to find new treatments and mitigate side effects, particularly for such problems as schizophrenia, depression, bipolar disorder and eating disorders.

"We really don't understand how most drugs currently used in brain disorders work," he explained. "If we can uncover how they exert their therapeutic actions, we hope to find drugs that are more effective. Additionally, if we can understand the side effects of current drugs, we'll know what molecular targets we have to avoid in making new drugs so they don't have the side effects."

Essentially, the work identifies both good targets for drug development, and bad targets to be avoided. In one application of the technique, Roth's lab identified potentially safe and effective compounds for treating obesity. Those compounds have been out-licensed to biotech companies for commercial development.

And In one of his most important research projects, Dr. Roth and his team at UNC, along with scientists at the University of California, San Francisco, developed and validated a computer model that can allow researchers to predict likely side effects before a drug is even put into clinical testing. The method compares the structures of all known drugs for various disease targets to their naturally-occurring binding partners. That comparison has revealed interactions between drugs and their targets that could not be predicted simply by studying their chemical structures.

A native of Butte, Montana, Roth graduated from Carroll College in Helena in 1977 with a degree in biology and chemistry. He subsequently earned his combined MD/PhD in Biochemistry in 1983 from St. Louis University School of Medicine.

He completed an internship in psychiatry at the National Naval Medical Center in Bethesda, Md. in 1984, and from 1983-1986 worked at the National Institute of Mental Health. During much of that period, he also worked at the Naval Medical Research Institute in Bethesda, first as a principal investigator and later as assistant division head of the institute's surgical research division.

In 1991 Dr. Roth concluded his residency in psychiatry at Stanford University Medical School, where he was also a Dana Foundation Fellow in Neurosciences in the Nancy Pritzker Laboratory of Molecular and Developmental Neurobiology. That year, he also received his first PhRMA Foundation grant.

After completing his studies at Stanford he held appointments at Case Western Reserve University School of Medicine for more than a decade in Departments of Psychiatry, and Biochemistry, ultimately becoming a Full Professor of Biochemistry in 2003. During much of that time he was on the faculty of Case Western Reserve University, where he specialized in the treatment of schizophrenia and, for a time, directed the Schizophrenia Research Ward at University Hospitals of Cleveland.

The annual Award in Excellence honors researchers who received PhRMA Foundation grants early in their careers and then distinguished themselves through outstanding scientific and/or academic achievements.

"This award is wonderful for me and for my lab. Essentially, the PhRMA Foundation makes a bet on young investigators, and no one knows for years whether it was a good bet or not. I am happy I was able to find success and, hopefully, will continue to find it for many years."

The Award in Excellence will be presented April 9 at a meeting of the American Society for Pharmacology and Experimental Therapeutics.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Shelene Bryan and Skip1.org Help Build Kitchen for Haitian Orphans
2. Fragile X researcher honored by March of Dimes
3. American Cancer Society honored for work in palliative care
4. Cedars-Sinai Medical Genetics Institute director honored with lifetime achievement award
5. Cancer prevention expert honored for innovative tobacco research
6. Investigators from Childrens Hospital LA honored
7. Economist honored for study on impact of new cancer drugs on life expectancy
8. Douglas A. Jabs, M.D., honored with Jackson Memorial Lecture by the American Academy of Ophthalmology
9. Early transcatheter valve recipient honored with Courageous Patient Award at TCT 2010
10. Free For All Honored for Explosive Growth, 2007 – 2009
11. MedStar Hospitals Honored at Obstetric Care Conference: The Third Annual PeriGen Knowledge Summit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bryan Roth honored for excellence in clinical pharmacology
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes ... of the facility as part of a disaster drill on October 3rd. , Apple ... Shelton City Emergency Manager, as well as the Connecticut Long Term Care Mutual ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
Breaking Medicine Technology: