Navigation Links
Brown researchers make major signal transduction discovery
Date:10/4/2007

PROVIDENCE, R.I. [Brown University] The chemical process known as acetylation plays a central role in cytokine receptor signal transduction a fundamental biochemical cascade inside cells that controls the activity of antiviral and tumor-suppressing genes.

A team of cell biologists led by Eugene Chin, M.D., a research professor at The Warren Alpert Medical School of Brown University and a staff researcher at Rhode Island Hospital, reports its findings in the journal Cell. Their results are surprising.

Scientists have long known that phosphorylation, an amino acid modifying process in proteins, is critical for switching receptors on and off on the surface of cells. Chin and his team studied how type 1 interferon binds to a receptor complex, known as the IFN-α receptor, on the cell surface to trigger an immune response. Chin and his team found that acetylation, another chemical process that modifies amino acids, plays a central role in activating interferon receptors.

Interferons play a crucial role in the bodys defense against infection and uncontrolled cell growth. Type 1 interferon is widely used to treat hepatitis B and C and cancers such as melanoma and leukemia.

This is a major discovery in the field of signal transduction, Chin said. Tyrosine phosphorylation has so far been considered the major player in signal transduction. But what we discovered challenges this concept. We found another player acetylation in the process.

In their experiments, Chin and his team looked at how cells respond to type 1 interferon, a protein produced in response to a viral infection or other immune trigger. The researchers found that type 1 interferon receptors, which are found in every cell in the body, call up cytoplasmic CREB-binding protein, or CBP, to move up to the cell surface. CPB acetylates these receptors. That, in turn, sparks a biochemical cascade that attracts more proteins to create a complex called ISGF3. To a
'/>"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Wholly Ingrained: White or Brown? Food War Going Racist? Get to the Heart of the Matter
2. Louisiana Residents Warned Against Brown Recluse Spiders
3. Scientists Identify "master Switch" for Brown Fat in Mice
4. Researchers urge caution in using ear tube surgery
5. Researchers Scale to assess the Severity of Epilepsy in Kids
6. Researchers identify the early makers of Neonatal Sepsis
7. OHSU Researchers Announce New Discovery
8. Researchers Identify Gene Connected To Bipolar Disorder
9. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
10. Researchers trick Alzheimers Enzyme
11. Researchers find new HIV hiding place
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... Joining a growing ... Hospital recently transitioned management companies to partner with Wound Care Advantage (WCA) to ... wound center. , Transitioning wound care management providers can be a complex ...
(Date:8/28/2015)... IL (PRWEB) , ... August 28, 2015 , ... With ... benefit concert returned for the second year to the Adams County Fairgrounds in Mendon, ... was held to raise money to support music education in the underfunded school districts ...
(Date:8/28/2015)... ... , ... On May 30th, 2015, Best Drug Rehabilitation, a results-based substance abuse ... Mission” benefit concert in Mendon, IL. Held in the Show Barn at the Adams ... education programs in the underfunded local school districts of Mendon at neighboring Quincy, IL. ...
(Date:8/28/2015)... Boynton Beach, FL. (PRWEB) , ... August 28, ... ... creating problems for businesses nationwide. Addictions specialist, Dr. James Strawbridge, gives a new ... Strawbridge believes that it should begin with the employer and employees getting together ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... a low cost. Personalized with practice contact information and logos, Calendars stand alone ... can also incorporate Calendars into seasonal mailings, thank you and welcome communications, and ...
Breaking Medicine News(10 mins):Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:SmartPractice® Introduces 2016 Calendars for Dental Practice Giveaways 2
... the profile for the usage of long-acting contraceptive methods. ... award, shows, amongst other things, that 10% of women ... "Long-acting contraceptives (the IUD, contraceptive injection or contraceptive ... at the Hospital del Mar in Barcelona and author ...
... eyestrain, poor posture, study finds , WEDNESDAY, Oct. 28 ... reduce the level of pain linked to poor posture ... just assume that problems will be solved by purchasing ... It,s also important to make sure the furniture is ...
... A clinical trial for ... Oak, and will open soon at the University of Michigan Comprehensive Cancer Center in Ann Arbor, ... ... women with an aggressive form of metastatic breast cancer is now open at Beaumont Hospital, ...
... ... supplement delivers enhanced speed, growth and productivity while replacing undefined media components such as ... ... 2009 -- InVitria presented the successful performance of its newest CHO cell culture ...
... 28 Two-time Major League Baseball (MLB) Manager ... featured on this month,s episode of Sharing Miracles - ... compelling and inspirational stories of real patients. Sharing Miracles ... stations nationwide. , An iconic figure in baseball, Torre ...
... Minn., Oct. 28 NeuroVasx, Inc., a medical device ... and ischemic stroke, announced today that the first procedure ... performed in Madrid. cPAX received CE Mark earlier this ... Endovascular and Percutaneous Treatment, Clinica Nuestra Senora del Rosario, ...
Cached Medicine News:Health News:The IUD is the most popular long-acting contraceptive amongst Europeans 2Health News:Takes a Pro to Make Offices Pain-Free 2Health News:Beaumont, U-M Open Study of Drug for Advanced Breast Cancer 2Health News:Beaumont, U-M Open Study of Drug for Advanced Breast Cancer 3Health News:Beaumont, U-M Open Study of Drug for Advanced Breast Cancer 4Health News:InVitria Reports Successful Cell Culture Performance of Zap-CHO, a Defined and Cost Effective CHO Cell Culture Media Supplement 2Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 2Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 3Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 4Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 5Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 6Health News:'Sharing Miracles' Television Program to Feature Baseball Manager, Cancer Survivor Joe Torre 7Health News:NeuroVasx Announces First Case of cPAX Aneurysm Treatment System in Spain 2Health News:NeuroVasx Announces First Case of cPAX Aneurysm Treatment System in Spain 3
(Date:8/27/2015)... 27, 2015  Now that Intuitive Surgical, Inc.® has ... surgical robot, hospitals with robotic surgery programs need to ... to see where they stand with robotic surgery. Are ... Have they adopted best practices for safety? Should they ... future? ECRI Institute, which has nearly 50 ...
(Date:8/27/2015)... , Aug. 27, 2015   ... Pharmacy Provider (IOPP™) is expanding its population ... a medication-focused transition of care program for ... "RxCare Management," provides hospitals with technology systems ... performance measures that have been mandated by ...
(Date:8/27/2015)... LAKEWOOD, Ohio , Aug. 27, 2015  A ... according to Booz Allen Hamilton . A ... that product development inefficiencies are impeding and disrupting manufacturers, ... Can Cut Waste and Improve Value In Product Development ... cost of inaccessible data and how it affects the ...
Breaking Medicine Technology:ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 3Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2New White Paper Reveals How Manufacturers Can Improve Product Development Processes 2
... , Feb. 17 New research ... Parkinson,s disease, according to a study released today that will be presented ... Toronto April 10 to April 17, 2010 . , ... the beginning of the research.  Participants were asked about their use of ...
... Italy , Feb. 17 The results of ... EVEREST (European Vertebroplasty Research Team) Centers (Dr. G.C. Anselmetti-Candiolo Torino, ... S. Masala-Roma , Dr. M. Muto-Napoli ,) confirms the ... that the procedure provides significant and sustained pain relief. , ...
Cached Medicine Technology:An Ibuprofen a Day Could Keep Parkinson's Disease Away 2Multi-Center Data in a Large Series of Patients Show Vertebroplasty Provides Dramatic and Lasting Pain Relief for Vertebral Compression Fractures 2Multi-Center Data in a Large Series of Patients Show Vertebroplasty Provides Dramatic and Lasting Pain Relief for Vertebral Compression Fractures 3Multi-Center Data in a Large Series of Patients Show Vertebroplasty Provides Dramatic and Lasting Pain Relief for Vertebral Compression Fractures 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: