Navigation Links
Brown researchers make major signal transduction discovery
Date:10/4/2007

PROVIDENCE, R.I. [Brown University] The chemical process known as acetylation plays a central role in cytokine receptor signal transduction a fundamental biochemical cascade inside cells that controls the activity of antiviral and tumor-suppressing genes.

A team of cell biologists led by Eugene Chin, M.D., a research professor at The Warren Alpert Medical School of Brown University and a staff researcher at Rhode Island Hospital, reports its findings in the journal Cell. Their results are surprising.

Scientists have long known that phosphorylation, an amino acid modifying process in proteins, is critical for switching receptors on and off on the surface of cells. Chin and his team studied how type 1 interferon binds to a receptor complex, known as the IFN-α receptor, on the cell surface to trigger an immune response. Chin and his team found that acetylation, another chemical process that modifies amino acids, plays a central role in activating interferon receptors.

Interferons play a crucial role in the bodys defense against infection and uncontrolled cell growth. Type 1 interferon is widely used to treat hepatitis B and C and cancers such as melanoma and leukemia.

This is a major discovery in the field of signal transduction, Chin said. Tyrosine phosphorylation has so far been considered the major player in signal transduction. But what we discovered challenges this concept. We found another player acetylation in the process.

In their experiments, Chin and his team looked at how cells respond to type 1 interferon, a protein produced in response to a viral infection or other immune trigger. The researchers found that type 1 interferon receptors, which are found in every cell in the body, call up cytoplasmic CREB-binding protein, or CBP, to move up to the cell surface. CPB acetylates these receptors. That, in turn, sparks a biochemical cascade that attracts more proteins to create a complex called ISGF3. To a
'/>"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Wholly Ingrained: White or Brown? Food War Going Racist? Get to the Heart of the Matter
2. Louisiana Residents Warned Against Brown Recluse Spiders
3. Scientists Identify "master Switch" for Brown Fat in Mice
4. Researchers urge caution in using ear tube surgery
5. Researchers Scale to assess the Severity of Epilepsy in Kids
6. Researchers identify the early makers of Neonatal Sepsis
7. OHSU Researchers Announce New Discovery
8. Researchers Identify Gene Connected To Bipolar Disorder
9. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
10. Researchers trick Alzheimers Enzyme
11. Researchers find new HIV hiding place
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 Residents at ... Community, recently showed their generous spirit by providing ... Catawba County Parenting Network- Grandparents Raising Grandchildren program. ... gathered around the largest Christmas tree on the ... purchased by residents of the Abernethy Village Association ...
(Date:12/25/2014)... Parker & Sons, Inc. an industry ... affordable quality regarding heating, cooling and plumbing services in ... by the “Queen of Clean” for impressive contractor services ... reputation over the years for providing outstanding quality customer ... contractor services for both homeowners and businesses. Linda Cobb, ...
(Date:12/24/2014)... 2014 Over 700 toys, that’s what ... communities. That is 700 smiling little faces this holiday ... over $6000 in monetary donations was given to the ... the expenses they incur through the year. Some of ... A Child's Haven , Shrine's Children's Hospitals, Toys for ...
(Date:12/24/2014)... TX (PRWEB) December 24, 2014 Connie ... specialist and functional medicine advocate with 30 years of ... trial to evaluate the health benefits of dietary detoxification. ... with new participants following excellent results from test patients ... When asked to explain her interest in conducting the ...
(Date:12/24/2014)... 24, 2014 Risperdal lawsuit ( http://www.risperdallawsuit2014.com/ ... tort litigation currently underway in Pennsylvania’s Philadelphia Court of ... December 24, 2014, court documents indicate that 1,183 claims ... individuals who developed gynecomastia (male breast growth) and other ... Court indicates that this represents an increase of more ...
Breaking Medicine News(10 mins):Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4
... Department of Emergency Medicine has received a two-year, $150,000 ... the implementation of electronic health records in a suburban ... work of Michael Ward, MD, an assistant professor at ... year focusing on simulation modeling in operations research, working ...
... , TUESDAY, June 7 (HealthDay News) -- Imaging ... a detrimental effect on the brain, according to a new ... of the drug caused a decrease in the number of ... bodily functions, including concentration, movement coordination, pleasure, pain tolerance, memory ...
... , TUESDAY, June 7 (HealthDay News) -- People ... do relatively few surgeries are at greater risk for serious ... were more common among patients at hospitals with low surgical ... according to the study, published online June 7 in ...
... sounds, smells and events: far too much for us to ... be snagged by something startling, such as a slamming door, ... to us right then, such as locating our child among ... know that people are hard-wired to seek out and pay ...
... (HealthDay News) -- Being in a serious relationship is not ... new research suggests. In fact, a study by researchers ... times more likely to have unprotected sex than casual partners. ... nearly 70 percent of all new HIV/AIDS diagnoses among adolescents ...
... U.S. Department of Agriculture (USDA)-funded studies of mammary gland ... interest may aid breast cancer research. In an early ... C. M. Simmen of the Arkansas Children,s Nutrition Center (ACNC) ... rat mammary gland health were improved in the offspring (pups) ...
Cached Medicine News:Health News:Using simulation to model the implementation of electronic health records 2Health News:Chronic Pot Smoking Affects Brain Chemistry, Scans Show 2Health News:Joint Replacement Risks Rise at Less Experienced Hospitals 2Health News:Your attention please: 'Rewarding' objects can't be ignored 2Health News:Your attention please: 'Rewarding' objects can't be ignored 3Health News:For Gay Men, Serious Relationships Still Harbor Risks for HIV 2Health News:Mammary gland development of blueberry-fed lab animals studied 2
(Date:12/24/2014)... 23, 2014 In response to urgent requests from the ... Sierra Leone , Direct Relief delivered two 10-bed ... the treatment of local health workers who contract Ebola while ... Ebola care center was constructed for foreign health care workers ... available for local Sierra Leonean health workers. With ...
(Date:12/22/2014)... JUNCTION, N.J. , Dec. 22, 2014 /PRNewswire/ ... company marketing its CytoSorb® blood purification technology to ... surgery patients in 28 countries worldwide, today announced ... Russo , MD, FACS, as its Senior Vice ... Dr. Di Russo ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) ... Blood Glucose Market" report to their offering. ... market insight focuses on the developments in the self-monitoring ... . Reimbursement analysis and the effects of competitive ... than 73 SMBG meters have been performed, based on ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2
... - Conference Call Today at 5:00 p.m. Eastern Time ... Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical ... the fourth quarter and year ended December 31, 2008, ... of 2008, we made significant progress toward our goal ...
... Calif., March 16 New Phase 3 data,published ... Urology, show that GELNIQUE(TM),(oxybutynin chloride) Gel 10%, the ... of overactive bladder (OAB), is effective at improving ... and is extremely well,tolerated in adults. , ...
Cached Medicine Technology:Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 2Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 3Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 4Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 5Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 6Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 7Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 8Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update 9New, Published GELNIQUE Data Show Efficacy, Convenience and Excellent Tolerability 2New, Published GELNIQUE Data Show Efficacy, Convenience and Excellent Tolerability 3New, Published GELNIQUE Data Show Efficacy, Convenience and Excellent Tolerability 4
Soft silicone brush tip allows atraumatic brushing and manipulation of retina surface. Silicone brush extends 3mm beyond end of cannula. Luer lock hub for easy, secure connection to a backflush handl...
Maumenee vitreous aspirating cannula, 18 gauge....
Reusable cannula with .90 mm (20 g) shaft, tapering to .60 mm (23 g) 3 mm from the tip. Overall length is 29 mm....
... silicone tip cannula allows atraumatic ... hole for aspiration of subretinal ... 6mm beyond end of cannula. ... easy, secure connection to a ...
Medicine Products: