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Brothers of prostate cancer patients undergo more diagnostic activities
Date:8/19/2010

ome clinically relevant.

The researchers also found that incidence of prostate cancer diagnosis among brothers of index patients was highest during the first year after the index patient's diagnosis.

Overall incidence of prostate cancer increased sharply in Sweden between 1999 and 2006, and a higher socio-economic status was associated with statistically significant increased risk of a prostate cancer diagnosis.

The authors conclude: "The increased diagnostic activity among men with a family history of prostate cancer, which we observed, will inflate family history as a risk factor for prostate cancer in populations of men who commonly receive PSA testing."

This finding could have clinical relevance, they report. "When counseling men about their risk of hereditary predisposition to prostate cancer, one should consider the possibility that a familial aggregation of prostate cancer may be at least partially caused by increased diagnostic activity," the authors write.

In an accompanying editorial, Ian M. Thompson, M.D., of The University of Texas, and colleagues, writes that assessments of variables affecting prostate cancer risk run the risk of unknown biases in most studies. They write: "Perhaps the best tactic would be to change our approach from seeking risk factors for prostate cancer to an assessment of factors related to biologically consequential prostate cancer."


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Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

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