Navigation Links
Brothers of prostate cancer patients undergo more diagnostic activities
Date:8/19/2010

The brothers of men with prostate cancer are at an increased risk of prostate cancer diagnosis because of increased diagnostic activity and not necessarily because they carry a genetic mutation that increases risk of the disease, according to a study published online August 19 in The Journal of the National Cancer Institute.

Family history is a stronger risk for prostate cancer than for many other cancers and many epidemiological studies have shown an increased risk of the disease for brothers and sons of men with the disease. Since the introduction and wide-spread usage of the prostate-specific antigen (PSA) test in the early 1990s, the sons and brothers of men with prostate cancer have undergone more diagnostic activity.

To determine whether or not estimates of the familial risk of prostate cancer may be at least partially inflated by detection bias from increased diagnostic activity, Ola Bratt, M.D., of the urology department at the Helsingborg Hospital in Sweden, and colleagues, looked at data from the Prostate Cancer Database Sweden for patients who were diagnosed with prostate cancer between 1996 and 2006 and who were registered in the National Prostate Cancer Registry.

Their analysis included 22,511 brothers of 13,975 "index patients," who were prostate cancer patients with one or more brother and their fathers registered in Sweden's Multi-Generation Register, which includes family information for Swedish residents born starting in 1932.

The researchers found that incidence of prostate cancer was higher among brothers of prostate cancer patients than men of the same age in Sweden and that the incidence was higher still among men with both a brother and father with prostate cancer. Incidence was highest among men who had two brothers with prostate cancer.

However, the type of cancer most often detected was early-stage prostate cancer, which is typically detected by a PSA test and may or may not become clinically relevant.

The researchers also found that incidence of prostate cancer diagnosis among brothers of index patients was highest during the first year after the index patient's diagnosis.

Overall incidence of prostate cancer increased sharply in Sweden between 1999 and 2006, and a higher socio-economic status was associated with statistically significant increased risk of a prostate cancer diagnosis.

The authors conclude: "The increased diagnostic activity among men with a family history of prostate cancer, which we observed, will inflate family history as a risk factor for prostate cancer in populations of men who commonly receive PSA testing."

This finding could have clinical relevance, they report. "When counseling men about their risk of hereditary predisposition to prostate cancer, one should consider the possibility that a familial aggregation of prostate cancer may be at least partially caused by increased diagnostic activity," the authors write.

In an accompanying editorial, Ian M. Thompson, M.D., of The University of Texas, and colleagues, writes that assessments of variables affecting prostate cancer risk run the risk of unknown biases in most studies. They write: "Perhaps the best tactic would be to change our approach from seeking risk factors for prostate cancer to an assessment of factors related to biologically consequential prostate cancer."


'/>"/>

Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. AthletiCo Employees Raise over $34,000 for Big Brothers Big Sisters of Metropolitan Chicago
2. AthletiCo Employees Raise over $34,000 for Big Brothers Big Sisters of Metropolitan Chicago
3. Spring Into A New Toll Brothers Dream Home During the National Spring Sales Event April 24 - May 2
4. Cleveland Cavalier Darnell Jackson teams with Big Brothers Big Sisters of Greater Cleveland to Issue “Mentoring Challenge”
5. Docs Shying Away From Drug That May Prevent Prostate Cancer
6. Study shows physicians reluctant to use chemoprevention for prostate cancer
7. Inhibiting prostate cancer without disturbing regular body processes
8. Surgery better than radiation, hormone treatments for some prostate cancer, study shows
9. Laser may reduce prostate surgerys sexual side effects
10. Purdue-IU team uncovers potential prostate cancer marker
11. New technique in robot-assisted laparoscopic prostatectomy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve their approach ... patient is doing more than filling out a survey; in many cases health professionals ... emphasis in health care and research on the importance of active engagement with patients ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The American ... to become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer ... Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
Breaking Medicine Technology: