Navigation Links
Brothers in arms
Date:3/17/2009

A joint venture from researchers from the Helmholtz-Centre for Infection Research (HZI) in Braunschweig, the Otto-von-Guericke-University in Magdeburg, and the Karolinska institute in Sweden have taken an in-depth look at the connection between flu infection and pneumonia. Their results, recently released in the scientific journal "PLoS One", have disproven a common theory about flu-like pneumonia.

Some viral infections trigger a decrease of immune cells in the blood a so-called "lymphopenia". The reasons behind it and whether this is the case with influenza are unknown. To investigate the latter, HZI researchers infected mice with flu viruses and measured the amount of immune cells in the animal's blood every day. Some days later, flu-infected mice received a dosage of pneumonia bacteria usually harmless for healthy mice. While the flu-infected mice did develop a superinfection & subsequently died, surprisingly, they were not suffering from lymphopenia. The healthy, non-flu-infected mice defeated the bacteria successfully and recovered.

To discover whether a lack of immune cells encourages an infection with pneumonia bacteria in general, an artificial drug-induced lymphopenia was established in the mice. Without infecting these lymphopenic mice with flu viruses, they received pneumonia bacteria. Despite a severe lack of immune cells, the mice recovered completely.

With these results, the researchers could show that influenza facilitates and intensifies an infection from pneumonia bacteria, while disproving the common idea that this is caused by a lack of immune cells. "This result was an enormous surprise for us because it directly contradicts widespread assumptions", says Sabine Stegemann, researcher in the groups "Immune regulation" at the HZI and "Molecular Immunology" at the Otto-von-Guericke-University in Magdeburg.

"Now we want to understand the reasons for the increased susceptibility", says Matthias Gunzer, head of the group in Magdeburg. "It could be interplay of weakened mucous membranes and scavenger cells that induce ideal conditions for pneumonia bacteria to create a deadly lung infection. Another reason may be a reaction of the host immune system: It disables hyperactive flu-fighting immune cells to inhibit destruction of healthy lung tissue. "The immune system keeps itself under control and that makes it easy for pneumonia bacteria to infect the lung", says Gunzer.


'/>"/>

Contact: Dr. Bastian Dornbach
bad@helmholtz-hzi.de
49-053-161-811-407
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Jonas Brothers Change for the Children Foundation to Provide Diabetes Camp Scholarships
2. Illinois Department of Veterans Affairs Presents $97,500 Veterans Cash Grant to Alexian Brothers Hospital Network
3. Special Guest Alonzo Mourning to Attend National Kidney Foundations 28th Annual Kidney Ball Featuring Entertainment by the Doobie Brothers
4. The National Kidney Foundation of the National Capital Areas 28th Annual Kidney Ball Featuring Entertainment by The Doobie Brothers
5. Pittsburgh Teen Raffles Her Jonas Brothers Tickets to Educate and Inspire
6. The Walt Disney Company Is Presenting Miley Cyrus, Jonas Brothers and Demi Lovato in a Special Concert to Benefit City of Hope on September 14
7. James Blake and Andy Roddick Team up With the Bryan Brothers for AnthemLIVE! 2008
8. Alexian Brothers Hospital Network Receives American Stroke Associations Get With The Guidelines Gold Performance Achievement Award
9. Three Miami Area Brothers and Physicians Assistant Charged In $110 Million Health Care Fraud Scheme
10. Brooks Brothers CEO at St. Jude Childrens Research Hospital(R) To Announce Partnership With Stanford St. Jude Championship
11. NBTY to Webcast Presentation at Lehman Brothers 11th Annual Retail and Restaurant Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... ... January 15, 2017 , ... In this role, Courtney will be responsible ... the asthma & allergy friendly mark. This certification program was created by ASL and ... products to be more suitable for the 60+ million people living in the U.S. ...
(Date:1/15/2017)... ... 2017 , ... "On Tour is a music themed slideshow production package which ... Austin - CEO of Pixel Film Studios. , On Tour’s new slide presets ... animation of their slideshows. Place each slide on top of another slide or piece ...
(Date:1/15/2017)... ... January 15, 2017 , ... The ... is pleased to announce that it will be assisting HackensackUMC Mountainside with its ... Glen Ridge townships, servicing all surrounding towns. The firm will be working closely ...
(Date:1/14/2017)... ... January 14, 2017 , ... "TransFreeze Volume 3 is a self animating masking transition which allows ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , TransFreeze ... transition from one clip to the next. , To use “Cut-Out First” presets, ...
(Date:1/13/2017)... ... January 13, 2017 , ... KOAMTAC ®, Inc., a leading manufacturer of ... generation companion scanner and data collector at the National Retail Federation’s Big Show (NRF17) ... an answer to the market’s need for more compact and rugged devices for collecting ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... --  The Harrington Discovery Institute at University ... has announced the 2017 recipients of Harrington Scholar-Innovator ... whose research shows promise to advance the standard ... – part of The Harrington Project for Discovery ... medicine: to advance early breakthroughs into the clinical ...
(Date:1/16/2017)... Jan. 16, 2017 When synthetic Fentanyl arrived on ... product as top-rate. They offered free samples, inviting would-be customers ... Soon, business was booming. ... 100 times more powerful than morphine, has racked up a ... last 2 years. One dealer,s recorded fentanyl sales reveals that ...
(Date:1/16/2017)... According to the new market research report "Display Controller Market by Type ... Controller), Application (Industrial Control, Medical Equipment, Automotive, Mobile Communication), and Geography - ... grow from USD 17.26 Billion in 2015 to reach USD 32.24 Billion ... Continue Reading ... ...
Breaking Medicine Technology: