Another research area is centered on variations in monoamine oxidase (MAO) genes and how they affect personality and vulnerability to psychiatric disorders. In earlier research, Fowler discovered that cigarette smokers have reduced levels of MAO, an enzyme that breaks down dopamine, the neurotransmitter that mediates reward, motivation and movement. This finding may account for the high rate of smoking in individuals who are depressed or addicted to drugs.
After earning a B.A. in chemistry at the University of South Florida in 1964 and a Ph.D. in chemistry at the University of Colorado in 1967, Fowler carried out postdoctoral research at the University of East Anglia, in Norwich, England, and at Brookhaven Lab. Joining the Laboratory in 1969, Fowler has spent her entire career at Brookhaven.
Fowler's honors include the Society of Nuclear Medicine's Paul Aebersold Award and the Department of Energy's E. O. Lawrence Award, both received in 1997; the American Chemical Society's Francis P. Garvin-John M. Olin Medal in 1998; and the Glen T. Seaborg Award in 2002. She was elected to the National Academy of Sciences in 2004, and, earlier this year, she was honored with the National Academy of Sciences Award in Chemical Sciences and was inducted into the Long Island Technology Hall of Fame. Fowler has published about 350 peer-reviewed articles and holds eight patents for radiolabeling procedures.
Three other Brookhaven Lab researchers have been honored with the National Medal of Science: Donald D. Van Slyke (Biological Sciences, 1965), Maurice Goldhaber (Physical Sciences, 1983), and Raymond Davis (Physical Sciences, 2001).
Fowler's research is funded by the U.S. Department of Energy's Office of Science, which provides infrastructure support for technology development, and the National Institutes of Health.
|Contact: Diane Greenberg|
DOE/Brookhaven National Laboratory