Navigation Links
Bronchiectasis increases mortality risk in moderate-to-severe COPD
Date:2/7/2013

Bronchiectasis is independently associated with an increased mortality risk in patients with moderate-to-severe COPD, according to a new study from researchers in Spain.

Bronchiectasis, a permanent and progressive dilation of the lung's airways, is common in COPD patients and is associated with longer and more intense exacerbations, more frequent bacterial colonization of the bronchial mucosa, and a greater degree of functional impairment.

"As COPD patients with bronchiectasis have an increased incidence of other known prognostic factors, we hypothesized that bronchiectasis itself would also have prognostic value," said lead author Miguel ngel Martnez-Garca, MD, of La Fe University and Polytechnic Hospital in Valencia, Spain. "We found that the presence and severity of bronchiectasis were associated with an increase in all-cause mortality in patients with moderate-to-severe COPD, independent of other known risk factors, including pulmonary function and other comorbidities."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The multicenter prospective observational study included 201 consecutive patients with moderate-to-severe COPD; 115 of them (57.2%) had bronchiectasis, which was diagnosed by high-resolution computed tomography (CT) scan of the chest. COPD severity was classified according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.

During a median 48 months of follow-up, there were 51 deaths, including 43 among the patients with bronchiectasis. In a multivariate analysis adjusted for dyspnea, body mass index, presence of potentially pathogenic microorganisms in sputum,comorbidities, number of severe exacerbations and other potentially confounding factors, bronchiectasis was associated with a significantly increased risk of all-cause mortality (hazard ratio 2.54, 95%CI, 1.16-5.56; p=0.02).Age, Charlson Index, and post-bronchodilator ratio of forced expiratory volume in 1 second were also shown to have prognostic value.

The study had a few limitations, including that some variables that have been shown to predict mortality in COPD were not included in the analysis and exact measurement of the size of the bacterial load in sputum samples was not possible.

"If the prognostic value of bronchiectasis in patients with moderate-to-severe COPD that we found is confirmed in further and larger studies, it would have an important clinical impact," said Dr. Martnez-Garca, "Bronchiectasis can be reliably diagnosed with high-resolution CT scanning, and effective treatments are available, potentially reducing the risk of mortality in patients with COPD."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Tuberculosis increases the risk of lung cancer mortality in the elderly
2. Bend Research increases hot-melt extrusion capacity
3. Despite less play, childrens use of imagination increases over 2 decades
4. Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients
5. Study shows no evidence medical marijuana increases teen drug use
6. Tai Chi increases brain size, benefits cognition in randomized controlled trial of Chinese elderly
7. US Drug Watchdog Dramatically Increases Their Efforts To Get All Recalled DePuy ASR Hip Implant Recipients Identified To The Best Possible Attorneys Before Time Runs Out
8. Prenatal exposure to common household chemical increases risk for childhood eczema, study says
9. Lung nodule matching software dramatically increases radiologists efficiency
10. Bacterial Vaginosis Increases Female-to-Male HIV Transmission Risk
11. Viewing terrorist attacks on TV increases pain intensity -- Ben-Gurion U. researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... the year of enhancements, upgrading their training and leads programs. , In February, ... Reserved for elite sales agents, Performance Partners is designed to teach how to ...
(Date:3/24/2017)... ... ... “End Time GPS”: a dauntless and enlightened study of the second-coming ... the creation of published author, Wesley Gerboth, a World War II veteran, with a ... Now, at age ninety-one, he shares the Wisdom God bestowed upon him in this ...
(Date:3/24/2017)... ... ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous ... the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks at ... her passion for writing, especially about truth and human behavior. , Published by Christian ...
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF ... the greater Houston Area. The new location is located at 2255 E. Mossy Oaks ... Springwoods Village. This newest location will provide patients living in the north Houston area ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... City Convention Center at 10 North Broadway Avenue, will be an educational and ... relevant, practical instruction in the management of chronic pain. , Oklahoma is in ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... Mar 23, 2017 Research and Markets has ... Trends - Industry Forecast to 2025" report to their offering. ... The Global ... 6.9% over the next decade to reach approximately $3.5 billion by ... forecasts for all the given segments on global as well as ...
(Date:3/23/2017)... March 23, 2017 ... created through extensive primary research (inputs from industry ... aims to present the analysis of global heart ... (Replacement and Repair); Replacement Procedure By Technique (Mechanical, ... Technique (Surgical Devices, Balloon Valvuloplasty, Transcatheter Mitral Valve ...
(Date:3/23/2017)... , March 23, 2017   BioSpace , ... resource, has partnered with Indiana Biosciences Research Institute ... organizations and educational institutions to bring the state,s ... first-ever BioIndiana Hotbed map, an artistic representation of the ... was presented to Vice President Mike Pence , ...
Breaking Medicine Technology: