Navigation Links
Broken genomes behind breast cancers
Date:12/23/2009

The first detailed search of breast cancer genomes to uncover genomic rearrangements is published today. The team characterised the ways in which the human genome is broken and put back together in 24 cases of breast cancer.

Rearrangements involve reshuffling and reorganisation of the genome and include deletions, duplications and novel juxtaposition of DNA sequences. The study shows that breast cancer samples can differ greatly in the extent to which they are subject to genomic rearrangements: some are relatively undisturbed whereas others are fractured extensively and then reassembled with more than 200 rearrangements present.

While it is known that the majority of cancer genes important in blood cancers are activated by rearrangement, the role of this process in the common adult cancers is much less clear. This new study builds on pioneering work from the team using next generation sequencing to characterise comprehensively rearrangements in adult solid tumours.

"We have looked at the level of the DNA sequence at just how splintered and reorganised the genome is in many breast cancers. We were, frankly, astounded at the number and complexity of rearrangements in some cancers." says Professor Mike Stratton of the Wellcome Trust Sanger Institute. "Just as important, the genomes were different from each other, with multiple distinctive patterns of rearrangement observed, supporting the view that breast cancer is not one, but several diseases."

The information obtained from this study will add a new dimension to tumour classification and thus refine diagnosis and treatment.

In the study, the team used next-generation DNA sequencing to produce maps of genome rearrangements in 24 breast cancer samples, which were chosen to include the major subtypes of breast cancer and also included examples of breast cancers arising in BRCA1 and BRCA2 breast cancer families.

One breast cancer showed just a single genomic
'/>"/>

Contact: Don Powell
press.officer@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Insurance Commissioner Says Federal Health Care Reform Necessary to Fix a Broken System
2. Ibuprofen Rated Best for Pain of Broken Arms
3. With a Broken Hip Comes Higher Risk for Dying
4. New AMA Ad Emphasizes Common Ground on Health Reform, Shares Vision to Fix Broken System
5. Nation Takes a Big Step Toward Learning Which Medical Treatments Work Best, a Major Advance in Fixing Our Broken Health-Care System
6. National Survey Reveals a Broken System for Chronic Disease Sufferers; National Council on Aging and Health Experts Explore Self-Care as a Viable, Consumer Focused Option for Health Reform
7. Physicians mending broken hearts
8. Registry Created for Broken Heart Syndrome
9. Using a Balloon to Repair a Broken Back
10. The Bold Leadership America Needs to Confront a Broken Healthcare System
11. Nurses to Congress: Expanding Medicare Could Reverse Job Losses, and Repair Our Broken Healthcare System and Safety Net
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... School of Medicine report that older women, plucky individuals ... are more likely to be compassionate toward strangers than ... this month,s issue of the International Journal of ... with better health and well-being as we age, the ... outcomes of individuals whose deficits in compassion put them ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... 2014) The cause of neuronal death in Parkinson,s ... that neurons may be mistaken for foreign invaders and ... the way autoimmune diseases like type I diabetes, celiac ... study was published April 16, 2014, in Nature ... controversial, idea in Parkinson,s disease; but if true, it ...
(Date:4/17/2014)... April 17, 2014 EcoHealth Alliance, a nonprofit organization ... published a comprehensive review today examining the current state ... The review calls for improved global surveillance strategies to ... recent outbreak of Ebola in West Africa that has ... of Guinea and Liberia. According to the World ...
(Date:4/17/2014)... NEW YORK (17 April 2014) Population Council scientists and ... is safe, stable, and can prevent the transmission of ... and rectum in animals: HIV, herpes simplex virus 2 ... provides the first data that the gel is effective ... of efficacy in the vagina against all three viruses ...
Breaking Medicine News(10 mins):Health News:The ilk of human kindness 2Health News:Building 'smart' cell-based therapies 2Health News:Is Parkinson's an autoimmune disease? 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2
... published in volume 14 issue 6 of World ... presented to Dr Cosimo Sperti of University of ... laparotomy performed in another hospital for an unresectable ... vein. Total pancreatectomy together with resection and reconstruction ...
... Ph.D., MBA, RN is vice president of research,and ... announced it,has appointed Joann Genovich-Richards, Ph.D., MBA, RN, ... research and measurement. The,position will support the development ... analyze existing data from accredited companies and,other sources ...
... March 13 inVentiv Clinical,Solutions, LLC (inVentiv Clinical), ... that they will establish operations in Latin,America, a ... will be,based in Sao Paulo, Brazil, with the ... inVentiv Clinical,s Latin American operations,will be led by ...
... TOC ; TSX: TOC) has been selected by ... care hospitals in high-growth urban and,suburban markets, to complete ... care hospitals., Like other health systems in the ... a limited field of candidates.,Thomson Healthcare, using its Market ...
... Ohio, March 13 Cardinal Health, a,global ... the safety and,productivity of health care, today ... Kaufmann as group president of its Healthcare ... role, Kaufmann, 45, will be responsible for ...
... the Future, JACKSON, Miss., March 13 ... technology partner, announces Christwood Retirement,Community in Covington, ... Study,(OBS) partner site for SamarionSolution(SM), the nursing ... Christwood, which recently celebrated a decade as ...
Cached Medicine News:Health News:URAC Announces New Leadership to Mine Health Care Management Data and Develop Measurement Programs 2Health News:URAC Announces New Leadership to Mine Health Care Management Data and Develop Measurement Programs 3Health News:inVentiv Clinical Expands Operations to Emerging Latin American Region 2Health News:inVentiv Clinical Expands Operations to Emerging Latin American Region 3Health News:Thomson Healthcare Undertakes Medical Staff Development Project for IASIS Healthcare 2Health News:Thomson Healthcare Undertakes Medical Staff Development Project for IASIS Healthcare 3Health News:Cardinal Health Names Michael C. Kaufmann to Lead Pharmaceutical Segment 2Health News:Samarion(SM) Announces Second Outcome Based Study Partner Site for LTC Industry's Only Enterprise Quality Improvement System 2Health News:Samarion(SM) Announces Second Outcome Based Study Partner Site for LTC Industry's Only Enterprise Quality Improvement System 3
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
(Date:1/14/2014)... 14, 2014 HeartWare International, Inc . (NASDAQ: ... invasive, miniaturized circulatory support technologies that are revolutionizing the ... expects revenues for the fourth quarter of 2013 will ... to approximately $208 million. "Our full-year revenue ...
(Date:1/14/2014)... , Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new ... targeting guide with accompanying instrumentation to place and insert ... to the soft tissue (e.g. ligament) repair or reconstruction ... repair heals. (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... Pfizer Inc. (NYSE: PFE ) today announced ... Read, 57, currently head of the Company,s global biopharmaceutical ... Read succeeds Jeffrey B. Kindler, who has retired from ... The Board,s Lead Independent Director, Constance J. Horner, said, ...
... Dec. 3, 2010 Opto Circuits (India) Ltd. [BSE ... completed the merger of its wholly-owned subsidiary, Jolt Acquisition ... result of the transaction, Cardiac Science has become a ... follows (i) Opto Circuits, acquisition, through a tender offer ...
Cached Medicine Technology:Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 2Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 3Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 4Opto Circuits Successfully Completes Acquisition of Cardiac Science 2Opto Circuits Successfully Completes Acquisition of Cardiac Science 3
Reagent Basin, 60mL, 5/Box...
Reservoir, 8 Well, 10/Box...
... manually adjustable dispensing head, and disposable, pre-sterilized ... cost-efficiency to microplate fluid dispensing. It is ... offer fast dispensing of fluids in a ... It also offers the added benefit of ...
The WellPro 384 is designed for use with 384 well microplates. It utilizes a 24 channel liquid head and can perform serial dilutions in a 16 or 24 across format, and plate to plate transfers and plat...
Medicine Products: