Navigation Links
Broccoli sprout-derived extract protects against ultraviolet radiation
Date:10/22/2007

A team of Johns Hopkins scientists reports in this weeks issue of the Proceedings of the National Academy of Sciences that humans can be protected against the damaging effects of ultraviolet (UV) radiation the most abundant cancer-causing agent in our environment by topical application of an extract of broccoli sprouts.

The results in human volunteers, backed by parallel evidence obtained in mice, show that the degree of skin redness (erythema) caused by UV rays, which is an accurate index of the inflammation and cell damage caused by UV radiation, is markedly reduced in extract-treated skin.

Importantly, notes investigator Paul Talalay, M.D., professor of pharmacology, this chemical extract is not a sunscreen. Unlike sunscreens, it does not absorb UV light and prevent its entry into the skin. Rather, the extract works inside cells by boosting the production of a network of protective enzymes that defend cells against many aspects of UV damage. Consequently, the effects are long-lasting; the protection lasts for several days, even after the extract is no longer present on or in the skin.

As skin cancer incidence is rising dramatically due to the escalating exposure of aging populations to the UV rays of the sun, Talalay says that treatment with this broccoli sprout extract might be another protective measure that alleviates the skin damage caused by UV radiation and thereby decreases our long-term risk of developing cancer.

The protective chemical agent in the broccoli sprout extracts is sulforaphane. It was first identified by Talalay and his colleagues more than 15 years ago and has been shown to prevent tumor development in a number of animals treated with cancer-causing chemicals.

After first testing mouse models of skin cancer to confirm sulforaphanes protective effects, Talalay and his team tested six healthy volunteers. Each one was exposed to a pulse of UV radiation on small patches of their skin (less than 1 inch in diameter) that were either treated or untreated with different doses of broccoli extract.

At the highest doses, UV-induced redness and inflammation were reduced by an average of 37 percent. The extracts were protective even when applied three days prior to UV exposure. The protection did vary considerably among the subjects, ranging from 8 percent to 78 percent, which Talalay notes may be due to genetic differences among individuals, local differences in the skin, or other factors such as dietary habits. He also points out that conventional sunscreens were essentially ineffective in these experiments.


'/>"/>

Contact: Nick Zagorski
nzagors1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Broccolis role against cancer
2. Compound of Broccoli combats breast cancer
3. Compounds Found In The Vegetable Broccoli Could Have Anti-Cancer Properties
4. Broccoli Found to Block Cancer Progression In Both Animal and Human Studies
5. A Boon For Gastritis Patients In The Form Of Broccoli
6. “Super Broccoli” Could Confer Better Cancer Protectin
7. Raspberries Are Richer In Anti-Oxidants Than Tomatoes Or Broccoli
8. Anti-Cancer Compound In Broccoli
9. Researchers Seek to Unlock Broccolis Cancer Fighting Secret
10. Pregnant Women- Eat Broccoli And Cabbage
11. Tomato and Broccoli Combo may Help Fight Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
Breaking Medicine Technology: