Navigation Links
Broccoli sprout-derived extract protects against ultraviolet radiation

A team of Johns Hopkins scientists reports in this weeks issue of the Proceedings of the National Academy of Sciences that humans can be protected against the damaging effects of ultraviolet (UV) radiation the most abundant cancer-causing agent in our environment by topical application of an extract of broccoli sprouts.

The results in human volunteers, backed by parallel evidence obtained in mice, show that the degree of skin redness (erythema) caused by UV rays, which is an accurate index of the inflammation and cell damage caused by UV radiation, is markedly reduced in extract-treated skin.

Importantly, notes investigator Paul Talalay, M.D., professor of pharmacology, this chemical extract is not a sunscreen. Unlike sunscreens, it does not absorb UV light and prevent its entry into the skin. Rather, the extract works inside cells by boosting the production of a network of protective enzymes that defend cells against many aspects of UV damage. Consequently, the effects are long-lasting; the protection lasts for several days, even after the extract is no longer present on or in the skin.

As skin cancer incidence is rising dramatically due to the escalating exposure of aging populations to the UV rays of the sun, Talalay says that treatment with this broccoli sprout extract might be another protective measure that alleviates the skin damage caused by UV radiation and thereby decreases our long-term risk of developing cancer.

The protective chemical agent in the broccoli sprout extracts is sulforaphane. It was first identified by Talalay and his colleagues more than 15 years ago and has been shown to prevent tumor development in a number of animals treated with cancer-causing chemicals.

After first testing mouse models of skin cancer to confirm sulforaphanes protective effects, Talalay and his team tested six healthy volunteers. Each one was exposed to a pulse of UV radiation on small patches of their skin (less than 1 inch in diameter) that were either treated or untreated with different doses of broccoli extract.

At the highest doses, UV-induced redness and inflammation were reduced by an average of 37 percent. The extracts were protective even when applied three days prior to UV exposure. The protection did vary considerably among the subjects, ranging from 8 percent to 78 percent, which Talalay notes may be due to genetic differences among individuals, local differences in the skin, or other factors such as dietary habits. He also points out that conventional sunscreens were essentially ineffective in these experiments.


Contact: Nick Zagorski
Johns Hopkins Medical Institutions

Related medicine news :

1. Broccolis role against cancer
2. Compound of Broccoli combats breast cancer
3. Compounds Found In The Vegetable Broccoli Could Have Anti-Cancer Properties
4. Broccoli Found to Block Cancer Progression In Both Animal and Human Studies
5. A Boon For Gastritis Patients In The Form Of Broccoli
6. “Super Broccoli” Could Confer Better Cancer Protectin
7. Raspberries Are Richer In Anti-Oxidants Than Tomatoes Or Broccoli
8. Anti-Cancer Compound In Broccoli
9. Researchers Seek to Unlock Broccolis Cancer Fighting Secret
10. Pregnant Women- Eat Broccoli And Cabbage
11. Tomato and Broccoli Combo may Help Fight Prostate Cancer
Post Your Comments:
(Date:11/25/2015)... ... 2015 , ... Beddit® has launched a new Android app for ... features a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and ... created by a proprietary algorithm. Beddit analyzes the data to provide an easy to ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... for people struggling with eating disorders as a result of the $20,000 raised ... event, held at Fox Run Golf Club in Eureka, will help individuals who ...
(Date:11/25/2015)... ... 2015 , ... Many people know of the common symptoms of low thyroid ... skin. But many people who find their cholesterol levels and weight are creeping up ... especially if they don’t have any of the other symptoms. , Thyroid hormone plays ...
(Date:11/24/2015)... Florida (PRWEB) , ... November 25, 2015 , ... ... planning and monitoring. Their Care Plan software creates an agreement between the ... patient care plan, including financial, scheduling, monitoring, notification, and projections. Click ...
(Date:11/24/2015)... ... ... Charitable giving is at its peak during the holidays. In fact, nearly ... year totalling over $358 billion in 2014. With more than 1.5 million U.S. ... who want to “give back” during the holidays. , “With so many charities to ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Calif. , Nov. 24, 2015 /PRNewswire/ ... leader in non-invasive genetic testing and the ... that it will present at the 27 ... York on Wednesday, December 2, 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, ... Company,s financial results, business activities and financial ...
(Date:11/24/2015)... November 2015 Avery Biomedical Devices ... ist erfreut, die Berufung von Anders Jonzon, ... zu können.   ... Foto -   ... 1984-1986 war er Fellow des Cardiovascular Institute ...
(Date:11/24/2015)... 2015   HeartWare International, Inc . (NASDAQ: ... support technologies that are revolutionizing the treatment of advanced ... Officer Doug Godshall is scheduled to present ... Conference on December 1, 2015 at 3:00 p.m. ET.  ... New York . ...
Breaking Medicine Technology: