Navigation Links
Broccoli Compound May Help COPD Patients

Sulphoraphane boosts lungs' antioxidant activity, researchers explain

FRIDAY, Sept. 12 (HealthDay News) -- People with chronic obstructive pulmonary disease (COPD) could one day benefit from an antioxidant compound in broccoli, researchers report.

COPD is the fourth-leading cause of death in the United States, affecting more than 16 million people, and is often the result of long-term smoking. There is no cure for this deadly disease, and current drugs do not slow its progression.

"In COPD, there is critical loss of antioxidant systems, which protect against oxidative stress and inflammation," explained lead researcher Shyam Biswal, an associate professor in the department of environmental health sciences and the division of pulmonary and critical care medicine at Johns Hopkins School of Medicine, in Baltimore.

"Even though there is a loss of this system, you can substantially restore it with an activator for this pathway," Biswal said. A compound in broccoli called sulforaphane has been shown effective in restoring antioxidant gene activity. "So this could be a new way of doing therapy," Biswal theorized.

The study is published Sept. 15 in the American Journal of Respiratory and Critical Care Medicine.

One of the things that was not understood before this work was why COPD patients carry a lot of oxidative stress, Biswal said. "Now we know the defense system in the lungs is getting lost -- but there is a hope that you can turn it on," he said. "Now that we know the target, we have to develop a therapy and see how effective it is."

Biswal noted that the big problem in COPD is not repairing the damage done to the lungs but rather preventing bacterial infection. "Most COPD patients manifest infection in the lungs and they die from that," he said.

What the researchers found is that a gene called NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a master gene that turns on many antioxidant and pollutant-detoxifying genes that protect the lungs from environmental pollutants, such as cigarette smoke.

However, levels of the protein produced by NRF2, and one of its regulators, DJ-1, are lower in COPD patients compared with patients without the disease. those levels are associated with the severity of the condition.

For this study, Biswal's group took lung tissue samples from smokers with and without COPD. The researchers compared the samples to see if there was a difference in the levels of NRF2 between people with and without COPD.

They also looked at levels of two biochemical regulators of NRF2, KEAP1 (which inhibits NRF2) and DJ-1 (which stabilizes it).

Biswal's team found that COPD patients had significantly lower levels of NRF2-dependent antioxidants, increased oxidative stress markers and a significant decrease in NRF2 protein, compared with non-COPD patients.

They also found that both groups had similar levels of KEAP1, but among COPD patients levels of DJ-1 was significantly lower. All of this indicates that NRF2 was there, but had been degraded.

So, agents that target NRFS -- including the sulforaphane found in broccoli -- might someday be harnessed to give the natural antioxidant systems of COPD patients a boost.

These strategies might prove effective in treating the disease, Biswal said. "It could be more effective, but a lot of study needs to be done," he said.

Dr. Norman H. Edelman, a professor of preventive medicine, internal medicine, physiology and biophysics at the State University of New York, Stony Brook, said the research is promising but far from having any treatment implications.

"The finding is of scientific importance because it may reveal a common pathway for antioxidant deficiency in COPD lungs," Edelman said. "Despite the talk of having clinical relevance, I would think that this is a long way off," he said.

More information

For more information on COPD, visit the U.S. National Library of Medicine .

SOURCES: Shyam Biswal, Ph.D., associate professor, department of environmental health sciences and the division of pulmonary and critical care medicine, Johns Hopkins School of Medicine, Baltimore; Norman H. Edelman, M.D., professor, preventive medicine, internal medicine, physiology & biophysics, State University of New York, Stony Brook, N.Y.; Sept. 15, 2008, American Journal of Respiratory and Critical Care Medicine

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Broccoli Sprout Extract Hinders Bladder Cancer Development
2. Blackberries, Broccoli Sprouts Battle Cancer
3. Broccoli May Help Fight Skin Cancer
4. Broccoli sprout-derived extract protects against ultraviolet radiation
5. Compound Could Reduce Heart Attack Damage
6. InNexus Biotechnology Announces Third Antibody and Expands Pipeline of Anticancer Compounds
7. USPTO Issues Patent Embodying Methodologies for Abating a Broad Range of Allergens, Pathogens, Viruses, Bacteria, Odors and Volatile Organic Compounds.
8. Study Finds Spice-Rich Marinades Can Reduce Harmful Compounds When Grilling
9. Microtest Offers New Services, Free Facility Audit, for Compounding Pharmacies Seeking USP 797 Compliance
10. ChromaDex Licenses Green Chemistry Technology to Manufacture a New Class of Super Fruit Compounds
11. Compound in Red Wine Fights Ravages of Age
Post Your Comments:
Related Image:
Broccoli Compound May Help COPD Patients
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article published November ... meeting in Washington D.C. revolved around the fact that proper dental care, both at-home ... stressed the link between periodontal disease (more commonly referred to as gum disease) and ...
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at which ... age, more care is needed, especially with Alzheimer’s, dementia and other cognitive conditions ... overworked. The forgotten part of this equation: 80 percent of medical care occurs ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When I was traveling, I ... Hillside, N.J. "Many people catch diseases simply from sitting on such dirty toilet ... protected from germs." , He developed the patent-pending QUDRATECS to eliminate the need ...
(Date:11/27/2015)... ... 27, 2015 , ... ProSidebar: Fashion is a set of 30 ... ProSidebar: Fasion, video editors can easily add an informative sidebar to any FCPX production. ... Utilize presets featuring self-animating drop zones, lines, bars, and text with the ease of ...
(Date:11/27/2015)... ... 2015 , ... Intellitec Solutions announced today that they have ... as Microsoft’s official group for end users of Dynamics SL ERP software, the ... experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing commitment to the ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... addition of the "Radioimmunoassay Market by ... (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic Labs), ... Global Forecast to 2020" report to ... has announced the addition of the ...
(Date:11/25/2015)... , Nov. 25, 2015  The American ... and Gynecologists (ACOG), and the March of Dimes ... Protecting Our Infants Act of 2015 ... number of newborns born exposed to drugs, such ... the bill,s introduction, all three organizations have worked ...
(Date:11/25/2015)... Nov. 25, 2015  Henry Schein, Inc., the world,s ... office-based dental, medical and animal health practitioners, will unveil ... Henry Schein ConnectDental® Pavilion , which brings together ... open solutions designed to help any practice or laboratory ... for a schedule of experts appearing at the ...
Breaking Medicine Technology: