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Broad Institute, MGH researchers chart cellular complexity of brain tumors
Date:6/12/2014

setts General Hospital and Harvard Medical School. He is also an Early Career Scientist of the Howard Hughes Medical Institute and a principal investigator at the Broad's Klarman Cell Observatory.

In addition to Bernstein and Regev, the study was led by co-first authors Anoop Patel and Itay Tirosh, who are postdoctoral fellows in the Bernstein and Regev labs respectively, and co-senior author Mario Suv, an assistant professor of pathology at MGH and a Broad associated scientist. The team represented a path-forging partnership between physicians and researchers from MGH's Departments of Neurosurgery and Pathology, and molecular and computational biologists at the Broad. The collaboration brought together neurosurgeons and pathologists at MGH, led by Patel and Suv, who removed the tumors from patients and molecularly characterized the samples; Broad biologists, led by John Trombetta and Alex Shalek, who conducted the single-cell analysis; and a computational team, led by Tirosh, that analyzed the data.

The team anticipates that the method and collaborative model will be effective in characterizing other cancer tumor types. Efforts to study additional cancers using the same methodology are currently underway.


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Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

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