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Brilliant blue G may shine in treating traumatic brain injuries
Date:2/11/2014

stage, let's temporarily block it," Dhandapani said.

That's where brilliant blue G appears to shine. They are retracing the steps following a traumatic brain injury to double check their findings that trauma activates NLRP3, a protein that drives the immune response, which activates interleukin , which causes an immune response that significantly contributes to swelling. They'll also be looking again at the efficacy of brilliant blue G at stopping the crescendo by giving it up to eight hours after the initial injury in their rodent model.

If they are correct, measuring levels of interleukin 1 in the blood could identify intensive care patients at risk for brain swelling and the dye, whose nearly identical chemical cousin is consumed daily by millions, could be given to stop it. Ideally, brilliant blue G also could be given prophylactically to high-risk groups such as soldiers and football players, Vender and Dhandapani muse.

"It's clinically safe, people are using it, so we know that we can use it. It's not going to cause toxicity and it's relatively inexpensive and easy to store," Dhandapani said. In fact, the only side effect the researchers have seen is, at therapeutic doses, mice in the study temporarily take on a blue hue.

It's also one of the first therapies to approach the problem early and at the molecular level. While improvements in prevention, such as better helmets, as well as lessons learned primarily from armed conflicts such as field resuscitation, rapid transport, and the concept of the golden hour have advanced survival rates for patients, "What we have not been able to do is prevent that 40 percent loss of function that is still occurring," said Vender.

As a neurosurgeon at a Level One Trauma Center, Vender performs hemicraniectomies where he temporarily removes a portion of the skull t
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Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

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