Navigation Links
Bright tumors, dim prospects

Sept. 13, 2007 -- It doesn't matter how small or large it is, if a cervical tumor glows brightly in a PET scan, it's apt to be more dangerous than dimmer tumors. That's the conclusion of a new study of cervical cancer patients at Washington University School of Medicine in St. Louis.

"We've seen that among patients with the same stage of cervical cancer, there will be some patients who don't respond to treatment as well as others," says lead author Elizabeth A. Kidd, M.D., a Barnes-Jewish Hospital resident in Washington University's Department of Radiation Oncology. "Our study suggests that PET (positron emission tomography) can reliably identify patients who have a poorer prognosis."

Kidd and her colleagues, including researchers with the Siteman Cancer Center at Washington University and Barnes-Jewish Hospital, report their findings in an upcoming issue of the journal Cancer.

The researchers used FDG-PET, a widely available three-dimensional scanning technique. FDG-PET measures how rapidly tumors take up a radiolabeled glucose tracer (FDG) high uptake results in a stronger or brighter signal in the scan. The researchers found that the higher the standard uptake value (SUV) for FDG in the primary tumor, the greater the recurrence rate and the lower the survival rate of patients.

"FDG-PET is the most commonly used PET scan," Kidd explains. "It's standard for patients to have this type of scan once diagnosed with cervical cancer. Oncologists use it to see the extent of the primary tumor and to look for tumors that have spread beyond the pelvis. But this study shows that the SUV obtained from FDG-PET can also tell physicians how well a patient will respond to treatment and should be part of the evaluation process."

A high SUV at diagnosis could signal that a patient should be followed more closely than usual after treatment to catch recurrences earlier, according to Kidd. She also indicates that although the results suggest that patients with high SUV tumors may need more aggressive treatments, further clinical studies will be necessary to determine the best therapy in such cases.

In the current study, 287 patients with cervical cancer were treated with surgery, chemotherapy or radiation therapy following standard treatment protocols. At the time of diagnosis, the SUV of their primary tumor was obtained. Their cancers were also staged under standard guidelines, which rely largely on tumor size and involvement with surrounding tissues. The patients' cancers ranged from early (stage 1A2) to highly advanced (stage 4B).

The researchers showed that patients who had a high tumor SUV were more likely to have aggressive disease: They were likely to have cancerous cells in their lymph nodes, persistent disease after initial treatment, recurrence of disease in the pelvis and lower survival rates. They also found that tumor SUV did not depend on the tumor stage or volume large tumors could have a relatively low SUV, and small tumors could have a high SUV.

The findings suggest that SUV is a more sensitive indicator of tumor aggressiveness than standard staging protocols. The study also demonstrated that SUV was better at predicting overall survival than the type of tumor or lymph node involvement, factors suspected to affect prognosis.

The patients were found to fall into three distinct risk groups. Those with the lowest SUV had a survival rate of 95 percent at five years, those in the middle SUV range had a 70 percent five-year survival rate, and those in the highest SUV range had a 44 percent five-year survival rate.

Because high SUV indicates that tumors take up glucose rapidly, the measurement may point to an important biological difference in these more aggressive cancers. "We're interested in finding out what causes that difference," Kidd says. "That could eventually lead to new methods for treating patients whose tumors have a high SUV."


Contact: Gwen Ericson
Washington University in St. Louis

Related medicine news :

1. Big and Bright
2. Sensitive to bright light? You may have sensitive teeth also
3. Bright arctic lights to cause headaches
4. Arthiritis: Brightly-coloured fruit and vegetables offer protection
5. Eating Seafood Results In Brighter Babies
6. Tooth-Whitening Products Work for Brightening Smiles in Short Term
7. Changes in Solar Brightness Too Weak to Explain Global Warming
8. Tougher Fiber Dental ‘bridges’ for a Brighter Smie
9. Statutory Warnings on Cigarette Packs- Make It Bigger and Brighter, Say Researchers
10. Bright Bodies Weight Program Lowers Diabetes Risk, BMI in Obese Kids
11. Marijuana Beneficial in Fighting Lung Tumors, Study
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... The Lymphoma Research Foundation ... research and serving the lymphoma community through a comprehensive series of education programs, ... Hope; A Commitment to Cure last night at the Mandarin Oriental in New ...
(Date:10/13/2015)... — , ... ... Association of America (MOAA) will hold its 2015 annual meeting ... a free military career fair; informational seminars; a luncheon featuring ... the Joint Chiefs of Staff; and the Community Heroes Award ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... Vision Group ... Vision of San Diego, California. With brands including The LASIK Vision Institute and TLC ... making it the nationwide leader in laser vision correction. , Global Laser Vision will ...
(Date:10/13/2015)... ... October 13, 2015 , ... PhyMed Healthcare Group , ... its partnership with WPC Healthcare , a provider of predictive analytics solutions ... data into an aggregated data repository necessary to perform reporting and analytics on ...
(Date:10/13/2015)... Texas (PRWEB) , ... October 13, 2015 , ... Symposium ... for the 19th annual Dallas Cosmetic Symposium to be held March 2nd and 3rd, ... place immediately afterwards, draws plastic surgeons and cosmetic physicians from around the world. , ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... YORK , Oct. 13, 2015 Pomerantz ... filed against Amicus Therapeutics, Inc. ("Amicus" or the "Company")(NASDAQ: ... filed in United States District Court, District of ... a class consisting of all persons or entities who ... 1, 2015 inclusive (the "Class Period"). This class action seeks ...
(Date:10/13/2015)... , Oct. 13, 2015  Vitamin Angels – ... and mothers in need of nutritional support - announced ... by the United Nations (UN). The UN,s newly established ... – are a recent follow up to the Millennium ... deadline for completion. The new 17 Global Goals intend ...
(Date:10/13/2015)... , Oct. 13, 2015   Generational Equity ... middle-market businesses, is pleased to announce the acquisition of ... in Largo, Florida , by Meridian ... on September 11, 2015. Florida ... --> Florida . To learn ...
Breaking Medicine Technology: