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Breathing easy: LSU biochemists offer first 3-D model of asthma-causing inflammation enzyme
Date:2/2/2011

ltered counterpart, and it was.

"Once we confirmed that it still produced the same thing, we essentially had a machine that makes the inflammatory compound but is stable enough so that we can study it," said Newcomer. "From there, we were able to determine the 3-D structure."

A better understanding of the structure allows for more effective targeting of the enzyme. This, in turn, should lead to fewer side-effects from drugs treating asthma.

"This work has so many implications," said Newcomer. "Our model is an important step toward actual application. The next step is to determine the structure of the machine in action with the substrates it operates on, but we cannot do this in the presence oxygen. This situation requires us to perform research in an oxygen-free environment. That's a tricky proposition, but this has really opened up the possibilities."

All preliminary work was done at CAMD, LSU's Center for Advanced Microstructures and Devices, by Gilbert, who is pursuing his Ph.D.

"We're excited to be a part of this big step forward in understanding 5-LOX and inflammation," said Newcomer.


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Contact: Ashley Berthelot
aberth4@lsu.edu
225-578-3870
Louisiana State University
Source:Eurekalert

Page: 1 2

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