Navigation Links
Breathing easy: LSU biochemists offer first 3-D model of asthma-causing inflammation enzyme
Date:2/2/2011

BATON ROUGE Inflammation is a healthy response in reaction to potentially harmful presences in the body. But when it starts in the lungs and builds up to a full-fledged asthma attack, it can be downright deadly. Chronic inflammation has been directly associated with heart disease and other physical ailments. But LSU graduate student Nathanial Gilbert and Professor of Biological Sciences Marcia Newcomer, together with Associate Professor Sue Bartlett, have developed the first 3-D model of Human 5-Lipoxygenase, or 5-LOX, the molecule responsible for creating inflammatory compounds that provoke asthma. This model will serve as a target for the design of new, more effective asthma medication.

Their research was printed in Science on Jan. 14 and was the subject of an article in Science Translational Medicine.

"This molecule is responsible for starting the synthesis of compounds referred to as 'signaling molecules,' which cause inflammation," said Newcomer. "If we can look at this molecule in closer detail than we have previously been able to do so, then that will allow for the development of better asthma medications that are able to stop an attack more effectively."

Prior to their development, scientists had been unable to study this molecule in detail because of its transient nature.

"It was really hard to work with," said Newcomer. "5-LOX is unstable. Before you could start your experiments, the enzyme would self-destruct."

The enzyme has an "Achilles' heel," which makes it prone to destabilization. But after working with another, hardier enzyme, Newcomer and her team were able to target the weak area, then bioengineer a replacement. Once they were able to apply this technique to 5-LOX, they were able to identify the complex pathway of how the molecule shuts itself off. The resulting molecule, complete with the engineered "heel," was then tested to verify that the output was precisely the same as its una
'/>"/>

Contact: Ashley Berthelot
aberth4@lsu.edu
225-578-3870
Louisiana State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mouth breathing can cause major health problems
2. Breathing Obstructions Caused by Sinusitis can Require Surgery, says Denver's Nose Doc
3. Allergy-Linked Mouth Breathing Spells Trouble for Kids
4. Premature Birth Ups Risk of Long-Term Breathing Problems
5. Breathing Exercises May Boost Athletes Performance
6. Questionnaires help dentists screen for sleep-disordered breathing in children
7. Sleep-disordered breathing is common but hard to detect in pediatric patients
8. Study finds a seasonal variance in sleep-disordered breathing in young children
9. Possible link between sleep-disordered breathing and cardiovascular disease revealed
10. Air Pollution Tied to Breathing Problems in Sleep
11. Wounded Congresswoman Breathing on Her Own: Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... Florida (PRWEB) , ... July 06, 2015 , ... ... solutions, announced today that Randstad Technologies selected Aspect Software Unified IP contact center ... the United States, selected Aspect Unified IP as its future call center platform. ...
(Date:7/6/2015)... ... , ... Diabetes affects many of us and the Glycemic Load and Alkaline ... majority of which are Type 2. However, eight million do not know they have ... prediabetes (abnormally high blood sugar levels). Without reductions in blood sugar levels and in ...
(Date:7/6/2015)... ... ... The Path of Least Resistance: The Evolution of Capitalism and Politics in ... over the past 40 years. The book explores the evolution of the global economy ... a time capsule that chronicles the economic development of the United States — from ...
(Date:7/5/2015)... ... 06, 2015 , ... City Sports, the Boston-based specialty sporting goods retailer, has ... for first-time triathletes this summer with ethos, the owner and operator of the Boston ... at 6:00 p.m. at the North End Greenway. The event will help new triathletes ...
(Date:7/5/2015)... (PRWEB) , ... July 05, 2015 , ... ... patented products, announces the Weed Master, a landscaping invention that effectively removes ... $75 billion US dollars," says Scott Cooper, CEO and Creative Director of World ...
Breaking Medicine News(10 mins):Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 3Health News:115 Million in the U.S. could beat diabetes with the help of a new app 2Health News:New Book Brings Reveals The Repercussions Associated With The Global Economy 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 3Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 2Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 3Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 4Health News:8 Landscaping Tips That Can Save You Money Thanks To World Patent Marketing's Innovative Landscaping Invention 5
... Derma Sciences, Inc. (OTC Bulletin Board: ... today that it has begun shipping BIOGUARD(TM) Barrier Dressings ... has been awarded reimbursement codes for the dressings, allowing ... will offer surgeons, wound care clinicians, infection control experts ...
... A study released earlier this month by Harvard Law ... found that medical bills are involved in more than ... six years ago. Additionally, more than 75 percent of these ... out-of-pocket expenses. In the wake of these startling increases and ...
... Center offers more services to autistic community with the help ... Judson Center ( www.judsoncenter.org ), a comprehensive ... of individuals and families, today opens the newly-constructed Autism Center ... headquarters. Judson Center employees, autism advocates and families as ...
... Rate of Invention in Applied Brain Science Continues to Accelerate ... the leading provider of brain fitness software, today announced that ... & Trademark Office. Posit Science now owns or licenses ... of applied brain science. , , Posit Science develops ...
... , ... of Alberta have found that there are significant differences in the way our brains function ... ... or a "night owl?", , ,Scientists at the University of Alberta have found that there ...
... Wan (Corporate Services) Ltd., the,sole agent of Perrier in Hong Kong is ... Perrier Clarifies the NITRITE ... believe the Consumer Council Findings is not correct. , ... Perrier is,not correct. , Nitrite content in Perrier ...
Cached Medicine News:Health News:Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings 2Health News:Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings 3Health News:Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings 4Health News:The Wellness Community Launches National Education Program Addressing the Cost of Cancer Care 2Health News:The Wellness Community Launches National Education Program Addressing the Cost of Cancer Care 3Health News:Judson Center Celebrates Grand Opening of its New Autism Center 2Health News:90 Brain Fitness Patents for Posit Science 2Health News:Morning People and Night Owls Show Different Brain Function: University of Alberta Study 2Health News:Perrier Clarifies the NITRITE Level in Consumer Council Findings 2
(Date:7/6/2015)... -- Impax Laboratories, Inc. (NASDAQ: IPXL ) announced today ... financial results on Monday, August 10, 2015, prior to ... will host a conference call and live webcast with ... August 10, 2015. The financial results and ... section of the Company,s Web site at http://investors.impaxlabs.com ...
(Date:7/6/2015)... PARIS , July 6, 2015 ... inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... Japan,s Ministry of Health, ... Confocal Laser Endomicroscopy solution, the AQ-Flex 19 miniprobe. ... Cellvizio AQ -Flex™ 19 miniprobe is comprised of ...
(Date:7/6/2015)... July 6, 2015  Protiviti, a global consulting firm, ... Auditing around the World publication ( www.protiviti.com/iaworld ). ... reported on the evolution of the internal audit profession ... globe as a means to providing senior executives and ... strategic business function. The 2015 edition of ...
Breaking Medicine Technology:Impax to Report Second Quarter 2015 Results on August 10, 2015 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3New Edition of Internal Auditing Around the World from Protiviti Explores Changes and Trends 2
... Ill., Oct. 8 Hospira, Inc. (NYSE: HSP ... signed a Business Cooperation Agreement with South Korea-based Celltrion, ... business terms of a future distribution agreement for the ... eight biogeneric products that are currently under development by ...
... , SAN DIEGO, Oct. 8 Adnavance Technologies Inc., ... medical applications, announced today that Randy White, Ph.D. chief ... of DNA targets in human clinical samples during company ... on Tuesday, October 13, 2009 at 10:00 a.m. Eastern ...
Cached Medicine Technology:Hospira, Celltrion, Enter Business Cooperation Agreement to Develop and Market Biogeneric Drugs 2Hospira, Celltrion, Enter Business Cooperation Agreement to Develop and Market Biogeneric Drugs 3Adnavance Technologies to Present Initial Data Supporting Direct Detection Molecular Diagnostic Tests at AdvaMed 2009 and BIOCOM Investor Conference 2
Intermittent catheter...
... Focus from Thermo Labsystems was designed specifically ... Advanced features such as the new fast ... on microvolumes help to define this as ... The new interchangeable handle plate offers a ...
Disease diagnosis and treatment reference sourced from Griffith's 5-Minute Clinical Consult. Save time diagnosing and treating more than 1,200 diseases and conditions....
... Flexible Band is a flexible partial ... alternative for surgeons who desire posterior ... Tailor® Annuloplasty Ring, which is designed ... rings, but like the option of ...
Medicine Products: