Navigation Links
Breath test can discriminate between a bacterial overgrowth and IBS

The gastrointestinal (GI) tract is colonized by bacteria immediately after birth; Escherichia coli, Streptococci and Clostridi are the first bacteria harboured by the colon, followed by anaerobic Enterococci, Lattobacilli and Bacteroidi. These commensal bacteria inhabiting the human intestine (i.e., intestinal microflora) participate in the development and maintenance of gut sensory and motor functions, including the promotion of intestinal propulsive activity; on the other hand, intestinal motility represents one of the major control systems of gut microflora, though the sweeping of excessive bacteria from the lumen. There is emerging evidence indicating that changes in this bi-directional interplay contribute to the pathogenesis of gut diseases, such as small intestinal bacterial overgrowth (SIBO).

Many factors affect the type and distribution of the bacteria along the GI tract, starting from the type of delivery and nursing in the first days of life, up to the food habits during the adult life: a SIBO is often present in adult population of westernized countries, because of poor daily intake of fibres and faecal stasis; such an overgrowth contributes to a chronic inflammation on intestinal mucosa and development of symptoms, such as abdominal pain, diarrhoea or stipsis.

These symptoms look like those of inflammatory bowel diseases (IBS) and, unfortunately, most of these patients with a bacterial overgrowth are inappropriately treated with topically-active non-steroidal anti-inflammatory agents. In fact, these compounds have no antibacterial activity and, therefore, they do not remove the causative factors of the symptoms (bacterial overgrowth) and are likely to provoke even severe adverse events.

The "breath test" is a recently developed test, which is able to detect elevated concentrations of hydrogen in the expired air. In presence of a SIBO, dietary carbohydrates are metabolised with production of massive amounts of hydrogen that are eliminated with the breath. Thus, the "breath test" consists in administering 50-75 grams of lactulose and assaying the concentrations of hydrogen in the expired air; if these concentrations exceed 10 to 20 part per million, the subject is suspected to have a SIBO and should be appropriately treated with antibiotics.

Clinicians should be encouraged to perform a "breath test" to promptly identify a bacterial overgrowth, because the disorder has several systemic consequences ranging from malabsorption of lipids and liposoluble vitamins and loss of electrolytes, to a more severe translocation of bacteria (usually, gram-negative and aerobic bacteria, such as Escherichia, Proteus, Enterobacter and Klebsiella) from the GI tract to extraintestinal tissues; all these factors may lead to sepsis and multiorgan failure.

Today, there is an effective treatment for bacterial overgrowth, which is rapidly corrected by the use of locally acting non-absorbable antibiotics, such as rifaximin polimorph A, which reverses the process (intestinal bacterial overgrowth) and prevents the cascade of events leading from intestinal low-grade inflammation to symptom development.


Contact: Jing Zhu
World Journal of Gastroenterology

Related medicine news :

1. MSAs Next-Generation Breathing Apparatus for Firefighters First to Receive Full NFPA Approval
2. Accordions Breathe Easier Since Smoking Ban
3. A Breath of Fresh Air From Washington: Senate Passes Historic Asbestos Ban
4. Hundreds to Gather for Rally in Celebration of Right to Breathe Clean Air
5. BREATHE Lung Cancer Conference, Nov. 30, Attracts World Renowned Physicians and Speakers
6. BODY WORLDS 2 & Breathe California Pair Up for Some Ash Kicking
7. BREATHE Lung Cancer Conference, Nov. 30, Offers Medical and Patient Education, Advocacy and Survivors Perspective
8. Childhood sleep-disordered breathing disproportionately affects obese and African-Americans
9. Radiology Support Devices Introduces New Breathing Phantom System
10. Elective Caesareans Raise Risk of Breathing Problems in Newborns
11. Overweight people more likely to have bad breath, TAU study finds
Post Your Comments:
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
Breaking Medicine Technology: