Navigation Links
Breath analysis offers non-invasive method to detect early lung cancer
Date:4/29/2014

Toronto, ON, Canada, April 29, 2014 Researchers at the University of Louisville School of Medicine are using breath analysis to detect the presence of lung cancer. Preliminary data indicate that this promising noninvasive tool offers the sensitivity of PET scanning, and has almost twice the specificity of PET for distinguishing patients with benign lung disease from those with early stage cancer. Michael Bousamra II, MD, Associate Professor, Department of Cardiovascular and Thoracic Surgery, is presenting the results of the study at the AATS 2014 Conference on April 29, 2014.

A reliable, noninvasive diagnostic method imposes less physical and financial burden on patients who actually have no significant disease, while rapid and accurate diagnosis expedites treatment for patients who truly have lung cancer.

The team believes that while the breath test would not replace CT as a primary screening tool, it would be particularly helpful in conjunction with a positive CT scan result. "This breath analysis method presents the potential for a cheaper and more reliable diagnostic option for patients found to have bulky disease on a CT scan. If the breath analysis is negative, the patient may, in some instances, be followed with repeated exams without necessitating a biopsy. But a positive breath analysis would indicate that the patient may proceed to definitive biopsy, thus expediting treatment," says Dr. Bousamra.

Investigators used specially coated silicon microchips to collect breath samples from 88 healthy controls, 107 patients with lung cancer, 40 individuals with benign pulmonary disease, and 7 with metastatic lung cancer.

Previous work had pinpointed four specific substances, known as carbonyl compounds, in breath samples as "elevated cancer markers" (ECMs) that distinguish patients with lung cancer from those with benign disease. The carbonyl compounds found in the breath are thought to reflect chemical reactions occurring in malignant lung tumors. In this study, the authors compared the findings from the breath analyses to the results from PET scans.

The investigators found that the sensitivity and specificity of breath analysis depended upon how many of the ECMs were elevated. For example, having 3 or 4 ECMs was diagnostic of lung cancer in 95% of those with this result. The majority of patients with benign pulmonary disease had either 0 or 1 ECM, while those with Stage IV cancer were most likely to have 3 or 4. The number of ECMs could be used to differentiate benign disease from both early and advanced stage lung cancer. Interestingly, 3 of the 4 elevated markers returned to normal levels after cancer resection.

When it comes to differentiating early stage lung cancer from benign pulmonary disease, breath analysis and PET scanning had similar sensitivities (82.8% and 90.3%, respectively). However, breath analysis had a much higher specificity than PET (75% vs. 38.7%, respectively) for distinguishing benign disease, which means that it was much more accurate at identifying those who did not have cancer. This would be an important feature for patients with benign disease, since having a breath analysis rather than PET scan could mean avoiding an unnecessary invasive biopsy procedure later on.


'/>"/>
Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery
Source:Eurekalert

Related medicine news :

1. Two breath compounds could be associated with larynx cancer
2. There is no beating the breathalyzer this St. Patricks Day (video)
3. Poison-breathing bacteria may be boon to industry, environment
4. Global Breath Analyzers Market is Expected to Reach USD 4.5 Billion in 2019: Transparency Market Research
5. Buteyko Breathing Technique Endorsed by Dr. Joseph Mercola
6. Chicago man breathes again thanks to Northwestern Medicine study
7. DWI Lawyer Evan Levow Says New Jersey State Needs to Find an Alternative to Breath Testing Alcotest Device
8. DWI Attorney Evan Levow Critical of NJ Breath Testing Program after Supreme Court Ruling, Urges Arrestees to Re-double Their Efforts to Protect Their Rights
9. Exhaled breath biomarker may detect lung cancer, study presented at Chest 2013
10. SafeToSleep Infant Breathing Monitor Nominated for Fifth National Parenting Award of 2013
11. Natural Remedies For Tonsil Stones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... New England Journal Of Medicine Confirms ... a Policy Response”, -The Rory Staunton Foundation Calls on Health & Human Services, Tom ... of Sepsis ( http://www.rorystauntonfoundation.org ) today reported on a new study released on May ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to ... While officials call for diligence, asking homeowners to scout for any open water sources ... Along with the annoying buzz of mosquitos is the buzz associated with potential infections ...
(Date:5/23/2017)... ... May 23, 2017 , ... Orbita’s Nathan Treloar will discuss the ... in San Francisco. Titled Connected Health and IoT: Technology Innovators and Disruption , ... by Parks Associates, a market research and consulting firm specializing in emerging consumer technology ...
(Date:5/22/2017)... ... May 22, 2017 , ... The American Academy ... development, healthcare training and clinical application of medical infrared imaging, has announced two ... medical thermal imaging services. , The first new educational offering is an online ...
(Date:5/22/2017)... ... May 22, 2017 , ... “Homeostasis: The Journey of a Manic-Depressive” tells ... Bipolar 1. Donald Rodriguez takes readers on a rollercoaster ride that includes a midnight ... winter and to a dark place where Donald considers suicide. Readers learn how ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... , May 4, 2017 Clarius Mobile ... wireless, handheld ultrasound scanners this week at the ... Meeting (ACOG) in San Diego, CA ... "Clarius is the perfect tool for clinicians ... heart rate, and evaluate pregnancy-related complications like ectopic ...
(Date:5/4/2017)... 2017  A new tight-tolerance microextrusion medical tubing ... materials, is being launched by Natvar, a Tekni-Plex ... in recent years to service a wide variety ... More expensive materials such as glass and fluoropolymers ... to their ability to consistently hold tolerances. This ...
(Date:5/3/2017)... , May 3, 2017  Kalorama Information notes ... nine percent next year and this is projected ... hematopoietic stem cell (HSCT) or bone marrow transplants ... technologies are well-suited for this task. This according ... publisher Kalorama Information. The various PCR-based methodologies, Sanger ...
Breaking Medicine Technology: