Navigation Links
Breastfeeding, other factors may affect risk of breast cancer type

Factors such as age at menopause as well as a woman's breastfeeding practices can influence her risk of developing certain types of breast cancer. That was the conclusion of a new study published in the October 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer.

Clinical differences among breast cancer subtypes have been well-described, but researchers have limited data on how the various subtypes arise and which individuals are at greatest risk. Having this information could help physicians identify which women are more likely to develop certain subtypes of breast cancer, which respond differently to different anti-cancer therapies and have very different survival rates.

Amanda Phipps, a predoctoral research associate at the Fred Hutchinson Cancer Research Center in Seattle, and her colleagues conducted a study to better understand the specific risk factors for the subtypes of breast cancer, which are classified by expression of the estrogen receptor, the progesterone receptor, and the HER2 receptor. Some breast cancer types express one or more of these proteins on their cell surface, while others express none. The research team suspected that reproductive or hormonal factors may play a significant role in a woman's risk of developing different subtypes because these cell receptors are influenced by endogenous sex hormones.

For their study, the scientists pooled two population-based studies of breast cancer in women aged 55-79 years. Their analysis included 1,023 women with breast cancer whose cells express the estrogen and progesterone receptors (called luminal cancers), 39 women with HER2-overexpressing breast cancer, and 78 triple-negative cases (no expression of estrogen, progesterone, or HER2 receptors). The study also included 1,476 women without breast cancer.

The investigators found that reproductive risk factors varied considerably by breast cancer subtype. For example, early age at menarche was associated with risk of HER2-overexpressing disease but not with any other subtype. Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Both late age at menopause and use of estrogen plus progestin hormone therapy were associated with an increased risk of luminal disease. Finally, no differences in risks associated with number of children or the age when a woman first gave birth were observed by subtype.

The study authors concluded that their results indicate that "certain reproductive factors may have a greater impact on risk of certain molecular subtypes of disease compared to others." They added that additional studies on the causes of breast cancer subtypes are needed to better understand the biology of the disease.


Contact: David Sampson
American Cancer Society

Related medicine news :

1. More girls than boys benefit from breastfeeding, Hopkins Childrens research shows
2. Another Reason Not to Smoke While Pregnant: Birth Defects
3. FDA Warns of Codeine Risk for Some Nursing Mothers
4. More than two-thirds of sexually active NYC youth use condoms, but other forms of birth control lag
5. One Species Genome Found Within Another
6. Claim Filed Against the Company and Nine Other Defendants in the Haifa Magistrates Court
7. Family-based treatment more effective than supportive psychotherapy in treating bulimia
8. Mother and Daughter Create Lead-Free/Safe Bibs and Solve Messy Mealtime Problems
9. Mothers Know Best: NFL Moms Team With Eddie George to Showcase a Better Way to a Healthier Lifestyle
10. Eat Seafood, See Weight Loss: Recent Study Finds Another Reason to Eat Seafood for a Fit Lifestyle
11. DTI Medical Corporation Announces Reverse Split and Other Corporate Developments
Post Your Comments:
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
Breaking Medicine Technology: