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Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
Date:5/30/2012

as developed by CCC researcher Dr. David Beebe, a UW professor of biomedical engineering.

The technique showed that LRP5 and LRP6 are linked structurally in a single signaling complex, called a heterodimer. Nobody has been able to make such an observation until now.

The dual-requirement for LRP5 and LRP6 was also observed in live mice that had the first stages of tumor growth, which depends on early ductal stem cell activity.

Pharmaceutical companies that produce breast-cancer drugs have focused most of their efforts on the Frizzled receptor and the more traditional canonical signaling pathway it uses. But that may change in the near future, Alexander says.

"Having a different Wnt receptor complex and signaling pathway is something drug companies would be interested in," she says.


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Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

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