Navigation Links
Breast stem cell fate is regulated by 'notch'
Date:10/8/2008

A normal developmental protein that sometimes goes awry has been implicated in breast cancer. This discovery indicates the mechanism by which inappropriate expression of the Notch pathway may contribute to breast cancer.

The breast cancer team at WEHI, led by Drs Jane Visvader and Geoff Lindeman from the Victorian Breast Cancer Research Consortium, have identified important roles for Notch genes in regulating breast development and function.

This discovery has important implications for breast cancer, since elevated levels of Notch have been linked to breast cancer. The advance builds on the group's 2006 discovery of the breast stem cell in mice.

Research carried out by Drs Toula Bouras and Bhupinder Pal has uncovered dual functions for Notch in breast tissue.

First, Notch helps restrict breast stem cell number, so that when Notch is 'switched off', there is a resultant expansion in breast stem cells.

Second, Notch is important for ensuring that stem cells produce the sleeve of cells that normally line breast ducts. These 'luminal' cells may be the cells that give rise to common types of breast cancer.

Thus, Notch helps to orchestrate the formation of breast tissue: it plays an important role in controlling stem cell number and instructs stem cells to produce luminal cells.

Significantly, Dr Bouras and colleagues found that errant activation of Notch resulted in uncontrolled growth of luminal precursors, leading to the formation of breast tumours.

The work has spotlighted the potential importance of deregulated Notch in ductal precursor cells as a forerunner to breast cancer.

The researchers say that it is too early to speculate on whether the design of anti-Notch therapies could help patients facing breast cancer.


'/>"/>

Contact: Brad Allan
allan@wehi.EDU.AU
61-393-452-345
Research Australia
Source:Eurekalert

Page: 1

Related medicine news :

1. deCODE Launches deCODE BreastCancer(TM), a Genetic Test to Screen for Risk of the Common Forms of Breast Cancer
2. Tamoxifen Speeds Diagnosis of ER-Negative Breast Cancer
3. BOOMj, Inc. Joins Fight Against Breast Cancer
4. Breast Cancer Awareness Blooms in October With ProFlowers
5. Plan Your Breasts in 3-D
6. International Implementation of Breast Health Guidelines for Developing Countries Published by Cancer
7. Susan G. Komen for the Cure(R), Speaker Dennis OBrien, Obama and McCain Health Care Advisors, Breast Cancer Survivors and Advocates Call for Needed Health Care Reforms
8. Ralphs to Invest $240,000 for Breast Cancer Awareness
9. Teleflora and Nationally Recognized Hospitals to Honor Women Battling Breast Cancer
10. Understanding Breast Cancer Risks & Management
11. Love/Avon Army of Women Breast Cancer Research Initiative to Launch Today
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... CO. (PRWEB) , ... August 22, 2017 , ... Each of the past six years, ... take attractive pictures of these labels and stickers, demonstrating the variety and creativity of their ... group of label images came in. Now, it's time to announce the winners of the ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Wilderness Voices”: a collection ... travel. “Wilderness Voices” is the creation of published author, Martha McKown, an ordained ... was inspired as a very young child when her older sisters studied High School ...
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating ... , As the stress of modern life continually makes more demands on time and ... artificial stimulants can trap people in vicious high/low cycles and can also cause long ...
(Date:8/21/2017)... (PRWEB) , ... August 22, 2017 , ... ... Judith I. Stevens as a 2017-2018 inductee into its VIP Woman ... in entrepreneurship. NAPW is the nation’s leading networking organization exclusively for professional women, ...
(Date:8/21/2017)... ... August 21, 2017 , ... Marathon running ... over the country. , Outdoor running increases exposure to ultraviolet radiation, a carcinogen ... risk of melanoma, and only half may be adequately protecting themselves with proper ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced financial ... unless otherwise noted, are to the quarter ended June 30, ... 2017 Highlights include: Revenue of $1,126 ... Total prescriptions dispensed of 220,000, compared to 241,000 ... Gross profit per prescription dispensed of $371, ...
(Date:8/3/2017)... , Aug. 3, 2017  Opioid addiction and ... driving up healthcare costs and threatening outcomes, were problems ... supply and IVD industry that support them, met this ... market researcher said that drugs of abuse, procalcitonin and ... sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... -- CaryRx, a next-generation full-service pharmacy, has announced the launch ... the Washington D.C. metropolitan area. CaryRx ... of medications through the convenience of its patient-friendly mobile app. ... one hour to any location in D.C. ... service to Washington D.C. ," says Areo ...
Breaking Medicine Technology: