Navigation Links
Breast milk may provide a personalized screen of breast cancer risk
Date:4/4/2011

ORLANDO, Fla. Breast cancer risk can be assessed by examining the epithelial cells found in breast milk, according to preliminary study results presented at the AACR 102nd Annual Meeting 2011, held April 2-6.

This screening method has the potential to provide a personalized assessment of breast cancer risk, said lead researcher Kathleen F. Arcaro, Ph.D., associate professor of veterinary and animal sciences at the University of Massachusetts Amherst. Given that roughly 80 percent of women give birth, this screen would also cover a large percentage of the female population.

Arcaro and colleagues collected breast milk samples from about 250 women who were scheduled for or who had a breast biopsy. The women submitted fresh samples, which were processed within 24 hours of expression; they provided samples from both breasts.

The researchers recruited about 90 percent of their study population from the Love/Avon Army of Women, which registers women who are willing to participate in breast cancer research. The American Association for Cancer Research is the scientific partner in this effort.

Once researchers received the samples, they isolated the epithelial cells (the potentially cancerous cells) in the breast milk. Then they isolated the DNA to look for epigenetic signals (attachment of methyl groups to DNA), which are the signals that tell the body those genes that should be expressed. These signals were then compared with breast cancer risk assessed using the biopsy results.

Arcaro and colleagues analyzed three genes: RASSF1, GSTP1 and SFRP1. "More than 35 genes have been shown to be methylated in breast cancer," she said.

Of the 104 women with a non-proliferative (low-risk) lesion, results showed no difference in the average epithelial DNA methylation of their biopsied breast vs. non-biopsied breast for RASSF1 and GSTP1. For SFRP1, however, the average methylation was higher in the biopsied breast. Importantly, among the women whose biopsies revealed cancer, there was a significant increase in average RASSF1 methylation in the biopsied breast vs. non-biopsied breast. Although the sample size in this study is small, "it's sufficient to tell us that we can use the cells in breast milk to assess breast cancer risk," Arcaro said, and additional studies are needed to expand the number of genes. Long-term studies are currently underway with about 80 percent of the original participants enrolled in follow-up.

Arcaro hopes that someday every woman who delivers a baby in a hospital will be screened for breast cancer via breast milk. "We'll take a little sample of colostrum, and we'll tell her how her breasts are doing," she said. "It's totally noninvasive, potentially inexpensive and really accurate."


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... As renowned, board-certified dermatologists, Dr. Sabrina G. Fabi ... patients who do not do their research and undergo cosmetic dermatology treatments from unqualified ... midst of a renaissance and every other month a new treatment or device is ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... CardioQuick Patch® significantly improves the reproducibility and accuracy of placing precordial electrodes with ... , Over the last 60 years, studies have shown that single electrode ...
(Date:12/4/2016)... ... ... James Earl Jones is known for myriad roles on stage and screen, he has ... the forthcoming episodes examines mammogram techniques; a very important part of preventative medicine. , ... detection. Like any other disease, treatments have a much higher chance of success if ...
(Date:12/4/2016)... ... December 04, 2016 , ... Patients who wish to gain ... of a cosmetic procedure known as Carbon Dioxide (C02) Fractional Laser Resurfacing ... age spots, fine lines, uneven coloration, wrinkles, scarring, skin laxity or textural ...
(Date:12/2/2016)... ... 02, 2016 , ... Lori G. Cohen and Sara K. ... at the American Conference Institute’s 21st Drug & Medical Device Litigation Conference , ... of the conference. , Cohen, who chairs the firm’s Pharmaceutical, Medical Device & Health ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , December 5, 2016 PharmaBoardroom today releases ... . ... This report offers companies, investors, policymakers, and stakeholders crucial insight ... of Europe , home to some of the world,s ... pharmaceutical companies in Novartis and Roche, and with a number one ranking ...
(Date:12/5/2016)... and TAIPEI, Taiwan , Dec. 5, 2016 ... treatment ropeginterferon alfa-2b showed non-inferiority to hydroxyurea (HU) in Complete ... better safety and tolerability profile of ropeginterferon alfa-2b versus HU ... and the ongoing long-term follow-up trial CONTINUATION-PV to obtain European ... intends to present this data to the FDA as it ...
(Date:12/4/2016)... Attorney General of Louisiana , Charles ... firm of Kahn Swick & Foti, LLC ("KSF"), announces that ... LCI ). On November 3, ... in Generic-Drug Probe to Be Filed by Year-End," which reported ... two years ago, now spans more than a dozen companies," ...
Breaking Medicine Technology: