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Breast-healthy lifestyle worthwhile, URMC study confirms
Date:10/11/2010

Having a family history of breast cancer can lead some people to wonder if their risk is out of their control. However, a study of more than 85,000 postmenopausal women observed that regular physical activity, maintaining a healthy weight, and drinking less alcohol lowers breast cancer risk for women with, and without a family history of the disease.

The University of Rochester Medical Center study, published online Oct. 12, 2010, by the journal Breast Cancer Research, is good news for women who have a close relative with breast cancer and thus fear that no matter what they do, it won't matter, said lead author Robert E. Gramling, M.D., D.Sc., associate professor of Family Medicine, and Community and Preventive Medicine at URMC.

"It's important to note that a family history of breast cancer can arise in part due to shared unhealthy behaviors that have been passed down for generations," Gramling said. "Untangling the degree to which genes, environments, and behaviors contribute to the disease is difficult. But our study shows that engaging in a healthy lifestyle can help women, even when familial predisposition is involved."

Gramling analyzed data from the Women's Health Initiative Observational Study that began in 1993. The data included women ages 50 to 79, but excluded women with a personal history of breast cancer or with a close relative with early-onset (before age 45) breast cancer.

Researchers decided to exclude women in the latter group because they wanted to focus on whether the American Cancer Society recommendations on diet, exercise and alcohol consumption could plausibly influence disease rates. Women with relatives who were diagnosed prior to age 45 might have a more dominant genetic pattern so they were excluded, the study said.

The WHI-OS data divided women into two groups, those who had a family history of later-onset breast cancer (after age 45) and those who did not. Researchers further cate
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Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

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