Navigation Links
Breast density change linked to cancer development in WHI hormone replacement study
Date:4/21/2010

Washington, DC --An increase in breast density appears to be the culprit behind an increase of breast cancer found in women participating in the estrogen and progestin therapy study, a part of the Women's Health Initiative (WHI). That is the finding of a new WHI analysis led by Celia Byrne, PhD, assistant professor at Georgetown Lombardi Comprehensive Cancer Center, and presented during the AACR 101st Annual Meeting 2010 in Washington, DC.

The WHI was launched in 1991 and consisted of a set of clinical trials and an observational study, which together involved 161,808 generally healthy postmenopausal women. One of the clinical trials examined the health effects of estrogen plus progestin therapy (EPT). The study was stopped early in 2002 because of an increased cancer risk found in those taking EPT. In the current analysis, researchers set out to determine if a change in mammographic density for EPT users could explain the increased breast cancer risk.

"In fact, that's exactly what we found," says Byrne. She adds that mammographic density is one of the strongest predictors of breast cancer risk suggesting that it might be a useful intermediate marker of change in breast cancer risk.

For the analysis, researchers obtained mammograms from study participants taken before they were randomized to the EPT or placebo arm of the WHI study. They also obtained mammograms from 97 women in the EPT arm who later developed invasive breast cancer. The mammograms (of the contralateral breast) were taken a year after they were randomized. In addition, the researchers collected mammograms from 77 women, also taken a year after they were randomized to the placebo arm. Finally, mammograms from a "random side" were collected for 733 health controls. The mammograms were digitized. Four experienced readers blinded to treatment and outcome assessed mammographic density, the proportion of the breast area appearing dense on the mammogram. The risk asso
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Studies Confirm Link Between Breast Density and Cancer
2. Change in breast density over time provides clues about breast cancer risk
3. Earlier Detection of Breast Cancer May Be Possible
4. Steady Weight Gain Boosts Late-Life Breast Cancer Risk
5. Increased EGFR levels may be an early marker of breast cancer
6. Body Mass Index gain throughout adulthood may increase risk of postmenopausal breast cancer
7. Protein plays a critical role in the development of aggressive breast cancer
8. New Guidelines Issued on Hormone Receptor Testing for Breast Cancer
9. Raloxifene, Tamoxifen Both Guard Against Breast Cancer
10. Supplements Might Reduce Breast Cancer Risk
11. Routine breast cancer biopsy might predict lymph node cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... St. Petersburg, FL (PRWEB) July 30, 2014 Phytceramides ... explains how and why in her new book. , Today is ... Phytoceramides: Anti Aging At Its Best . The book is ... larger skin care book, but felt that Phytoceramides were ... sense to bring out this focused book now," says Kathy Heshelow, ...
(Date:7/29/2014)... Daily Gossip indicates that the new method ... symptoms that hemorrhoids commonly causes. The new method was ... expert. , The author of H Miracle reveals ... symptoms such as itching, burning, pain and swelling, as ... H Miracle by visiting the official website at: ...
(Date:7/29/2014)... 29, 2014 Daily Gossip reveals in its ... program claims that he cured his condition with the use ... share part of his experience. , He claimed that ... naturally in just 4 days. Since his method turned out ... from all around the world. , The Nasal Polyps ...
(Date:7/29/2014)... 29, 2014 DailyGossip.org reveals in its ... is a new method of naturally overcoming sciatica, in ... the new method ensure sufferers that the cure is ... , The new method is described as very ... sciatica with an 8 minutes per day treatment plan. ...
(Date:7/29/2014)... DailyGossip.org reveals in its latest review that ... can perfectly understand patients and what they have to go ... is the author of the new program. Ellie claims that ... suffering, Ellie started her very own research. Four years passed ... author of the Get Rid of Cold Sores program claims ...
Breaking Medicine News(10 mins):Health News:Last Day New Book Is Available at No Cost: Phytoceramides, Anti Aging At Its Best by Sublime Beauty Founder® Kathy Heshelow 2Health News:Last Day New Book Is Available at No Cost: Phytoceramides, Anti Aging At Its Best by Sublime Beauty Founder® Kathy Heshelow 3Health News:H Miracle Review Exposes Natural Method to Cure Hemorrhoids 2Health News:Nasal Polyps Treatment Miracle Review Reveals How to Cure Nasal Polyps Without Surgery 2Health News:Stop Sciatica in 8 Minutes Review Reveals the Way to Cure Sciatica Easily 2Health News:Get Rid of Cold Sores Fast Review Exposes the Way to Stop Outbreaks 2
... apnea, a dangerous medical condition that becomes more prevalent as ... deadly if left// untreated, says an expert. ,The ... irritation, with people being unaware that they are causing more ... the online edition of health portal News Medical. ...
... 'An ounce of prevention is worth a pound of cure.' , ... disease that could wipe the smile// off many faces and cause ... 43% of all cancers are preventable. Sunday, 4 February 2007, is ... will focus on strategies for a cancer free world – a ...
... College of Medicine finds that naltrexone may be beneficial to ... is often used to bring// relief to victims of alcohol ... inflammatory disorder of the intestine that affects an estimated 500,000 ... an early edition of the American Journal of Gastroenterology. ...
... hair dye are increasing as more and younger people dye ... dermatitis on the face and, in severe cases, facial swelling ... dyes currently contain para-phenylenediamine (PPD) and other related agents. During ... serious problem that it was banned from hair dyes in ...
... A promising step forward in the field of AIDS was ... to this 2-5AN6B, a nucleic acid, could actually stop the// ... ,This work was led by Robert J.Suhadolnik, Professor of ... 2-5AN6B in combination with drugs currently used for AIDS treatment ...
... menstrual cycles affect the responsiveness of their brains’ reward ... Mental Health (NIMH), a component of the National Institutes ... women were winning rewards, their circuitry was more active ... and dominated by estrogen, compared to a phase when ...
Cached Medicine News:Health News:'Cancer Prevention' - In Your Hands 2Health News:'Cancer Prevention' - In Your Hands 3Health News:NIMH Studies Woman’s Hormonal Cycl 2
(Date:7/29/2014)... 29, 2014 /PRNewswire-iReach/ -- MHG Medical Management Services, ... its Medical Equipment and X-ray Annual Inspection ... tailored to the cruise industry,s unique requirements.  MHG ... to propose that they should develop a new ... is intended to create standardized processes and raise ...
(Date:7/29/2014)...  Roche (SIX: RO, ROG; OTCQX: RHHBY) launched its ... 2014 Clinical Lab Expo today by unveiling two booths ... is partnering with customers to redefine the value of ... day that they,re looking for a partner to help ... and offices," said Jack Phillips , president and ...
(Date:7/29/2014)... 2014  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... second quarter 2014 financial results after the Nasdaq market ... host a live conference call and webcast to discuss ... morning, August 7, 2014 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1907 (US) or ...
Breaking Medicine Technology:MHG Medical Management Services Aims to Change Cruise Industry Standard With New Equipment Maintenance Program 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4Neurocrine Biosciences Announces Conference Call And Webcast To Report Second Quarter 2014 Financial Results 2
New!...
...
Mendez Multi-Purpose LASIK Forceps. To enter, dissect, elevate and smooth the flap. Combined features of Spatula, Dissector and Forceps, Titanium...
The CGPL capsulotomy contact glass was designed by Riquin, Fankhauser et al. for the dissection of opacified posterior lens capsules and membranes in the pupillary and retropupillary space with the Y...
Medicine Products: