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Breast cancer's many drivers
Date:6/20/2012

al compounds to see how effective they might be at targeting cells that harbor this fusion gene's protein.

Beyond these scientific findings, the study also represents a closer look at the Latino population, thanks to the collaboration between the Broad and INMEGEN forged through the Slim Initiative in Genomic Medicine.

"The Slim Initiative in Genomic Medicine aims to support the discovery of the genetic basis of diseases such as type 2 diabetes mellitus and several types of cancer which have a profound public health impact in Mexico and Latin America," said Roberto Tapia-Conyer, director general of the Carlos Slim Health Institute. "This novel bi-national scientific collaboration is contributing to put the Latin American genome on the map of the second generation worldwide genome studies."

INMEGEN scientists had previously built a large breast cancer study and then scientists at both the Broad and INMEGEN exchanged clinical, biological, and computational information.

"From the Mexican point of view, you can say the Latino population has not been extensively characterized using genomic methods," Hidalgo Miranda said. "This is a significant contribution to the knowledge of the architecture of breast tumors in this particular population."

The study represented a first opportunity to study the genetic basis of breast cancer in Mexico. Larger studies will be required to determine whether differences in the spectrum of mutations exist between different populations, but this was an important first step toward that goal.


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Contact: Nicole Davis
ndavis@broadinstitute.org
617-714-7152
Broad Institute of MIT and Harvard
Source:Eurekalert

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