Navigation Links
Breast cancer type linked to paternal cancer
Date:11/28/2011

The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's open access journal BMC Cancer looked at the relationship between women with breast cancer and diagnosis of cancer in their parents. The results showed that the chances of women with lobular breast cancer having a father with cancer (especially prostate cancer) was almost twice as likely as women with other forms of breast cancer.

Researchers from Lund University looked at the family history, pathology reports and hospital records for women diagnosed with breast cancer between 1980 and 2008. About 40% of the women had invasive ductal breast cancer and 8% had lobular cancer. At diagnosis, 15% of all these women had a father with cancer and 21% had a mother already diagnosed with cancer.

Once the data was adjusted for age, use of HRT, number of children, and known genetic factors, such as having a mother with breast cancer, a woman having a father with cancer almost doubled the risk of having lobular cancer, when compared to any other type of breast cancer.

Since breast cancer is often hormonally driven (in this study 63% of women with lobular cancer were estrogen receptor positive), it might be assumed that the type of cancer the father had could be important. However the increase in risk of lobular breast cancer due to having a father with cancer was independent of both estrogen receptor and progesterone receptor status. Prostate cancer is also often hormonally driven but the link between lobular cancer and a father with cancer remained even after removing the group of fathers with prostate cancer from the analysis.

Carolina Ellberg who performed this research explained, "We also looked at grandparents and other family members, but the increased risk of lobular cancer was directly linked to having a father with cancer. This does not necessarily mean that the daughter of a man diagnosed with cancer is more likely to get lobular breast cancer - it means that if she develops breast cancer it is more likely to be lobular."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Related medicine news :

1. Breast Cancer and the Environment: IOM report release Dec. 7
2. Canadian breast cancer screening guidelines would cost thousands of lives
3. New breast cancer screening guidelines released
4. FDA Revokes Approval of Avastin for Breast Cancer
5. Easy-to-Treat Condition Can Disrupt Breast-Feeding
6. Tender Breasts From Combo HRT Linked to Higher Cancer Risk
7. Combo hormone therapy has increased breast cancer risk over estrogen alone
8. PBX1 identified as a new pioneer factor underlying progression in breast cancer
9. Early breast cancer detection saves lives
10. Tamoxifen causes significant side effects in male breast cancer patients
11. Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... VA (PRWEB) , ... May 26, 2017 , ... ... pleased to announce a new educational seminar to focus on current legislative activity ... News(LEARN) seminar will begin at 1 p.m. Sunday, Sept. 10, and will continue ...
(Date:5/26/2017)... ... May 26, 2017 , ... via ... antimicrobial, mesh back 24/7 task chair specifically designed for clinical areas. Genie Copper ... thrilled to partner with Cupron® to provide customers with a game changing chair ...
(Date:5/26/2017)... ... 26, 2017 , ... Rob Lowe acts as host and helps educate and ... on hiking in American. Viewers can reconnect with America as it explores some of ... Many consumers have looked for an inventive new place for a family vacation, and ...
(Date:5/26/2017)... ... ... What Happened in the Garden of Eden”: retells the stories of three Bible figures in ... published author, Penelope Colt, mother, trader, horse farmer, artist and a former GM journeyman. ... At six, they moved to Dayton, Ohio, where Penny graduated high school. At ...
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Alan I. Benvenisty, MD is dual board ... He is known for his distinguished expertise and experience in the diagnosis and treatment ... training in treating renovascular disease and aortic aneurysm . He is known for ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... , May 9, 2017  Demonstrating its commitment ... of directors for the Pharmaceutical Research and Manufacturers ... membership. Biopharmaceutical companies will now have to meet ... to be eligible to join PhRMA. ... board is sending a clear message that being ...
(Date:5/8/2017)... Mich. , May 8, 2017  Diplomat Pharmacy, ... WRB Communications, Inc. ("WRB"), a health care service ... . WRB specializes in relationship management programs ... WRB will join ... Diplomat,s commercialization support services for manufacturers, biotech firms, and ...
(Date:5/4/2017)... May 4, 2017  Fortuna Fix Inc. (" Fortuna ... the first to eliminate the need for embryonic and fetal ... treat neurodegenerative diseases. Fortuna announced today ... Michael Fehlings , MD, PhD; Father Kevin FitzGerald ... MPH; and Professor James Giordano , PhD. ...
Breaking Medicine Technology: