Navigation Links
Breast cancer type linked to paternal cancer

The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's open access journal BMC Cancer looked at the relationship between women with breast cancer and diagnosis of cancer in their parents. The results showed that the chances of women with lobular breast cancer having a father with cancer (especially prostate cancer) was almost twice as likely as women with other forms of breast cancer.

Researchers from Lund University looked at the family history, pathology reports and hospital records for women diagnosed with breast cancer between 1980 and 2008. About 40% of the women had invasive ductal breast cancer and 8% had lobular cancer. At diagnosis, 15% of all these women had a father with cancer and 21% had a mother already diagnosed with cancer.

Once the data was adjusted for age, use of HRT, number of children, and known genetic factors, such as having a mother with breast cancer, a woman having a father with cancer almost doubled the risk of having lobular cancer, when compared to any other type of breast cancer.

Since breast cancer is often hormonally driven (in this study 63% of women with lobular cancer were estrogen receptor positive), it might be assumed that the type of cancer the father had could be important. However the increase in risk of lobular breast cancer due to having a father with cancer was independent of both estrogen receptor and progesterone receptor status. Prostate cancer is also often hormonally driven but the link between lobular cancer and a father with cancer remained even after removing the group of fathers with prostate cancer from the analysis.

Carolina Ellberg who performed this research explained, "We also looked at grandparents and other family members, but the increased risk of lobular cancer was directly linked to having a father with cancer. This does not necessarily mean that the daughter of a man diagnosed with cancer is more likely to get lobular breast cancer - it means that if she develops breast cancer it is more likely to be lobular."


Contact: Dr. Hilary Glover
BioMed Central

Related medicine news :

1. Breast Cancer and the Environment: IOM report release Dec. 7
2. Canadian breast cancer screening guidelines would cost thousands of lives
3. New breast cancer screening guidelines released
4. FDA Revokes Approval of Avastin for Breast Cancer
5. Easy-to-Treat Condition Can Disrupt Breast-Feeding
6. Tender Breasts From Combo HRT Linked to Higher Cancer Risk
7. Combo hormone therapy has increased breast cancer risk over estrogen alone
8. PBX1 identified as a new pioneer factor underlying progression in breast cancer
9. Early breast cancer detection saves lives
10. Tamoxifen causes significant side effects in male breast cancer patients
11. Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: