Navigation Links
Breast cancer type linked to paternal cancer
Date:11/28/2011

The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's open access journal BMC Cancer looked at the relationship between women with breast cancer and diagnosis of cancer in their parents. The results showed that the chances of women with lobular breast cancer having a father with cancer (especially prostate cancer) was almost twice as likely as women with other forms of breast cancer.

Researchers from Lund University looked at the family history, pathology reports and hospital records for women diagnosed with breast cancer between 1980 and 2008. About 40% of the women had invasive ductal breast cancer and 8% had lobular cancer. At diagnosis, 15% of all these women had a father with cancer and 21% had a mother already diagnosed with cancer.

Once the data was adjusted for age, use of HRT, number of children, and known genetic factors, such as having a mother with breast cancer, a woman having a father with cancer almost doubled the risk of having lobular cancer, when compared to any other type of breast cancer.

Since breast cancer is often hormonally driven (in this study 63% of women with lobular cancer were estrogen receptor positive), it might be assumed that the type of cancer the father had could be important. However the increase in risk of lobular breast cancer due to having a father with cancer was independent of both estrogen receptor and progesterone receptor status. Prostate cancer is also often hormonally driven but the link between lobular cancer and a father with cancer remained even after removing the group of fathers with prostate cancer from the analysis.

Carolina Ellberg who performed this research explained, "We also looked at grandparents and other family members, but the increased risk of lobular cancer was directly linked to having a father with cancer. This does not necessarily mean that the daughter of a man diagnosed with cancer is more likely to get lobular breast cancer - it means that if she develops breast cancer it is more likely to be lobular."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Related medicine news :

1. Breast Cancer and the Environment: IOM report release Dec. 7
2. Canadian breast cancer screening guidelines would cost thousands of lives
3. New breast cancer screening guidelines released
4. FDA Revokes Approval of Avastin for Breast Cancer
5. Easy-to-Treat Condition Can Disrupt Breast-Feeding
6. Tender Breasts From Combo HRT Linked to Higher Cancer Risk
7. Combo hormone therapy has increased breast cancer risk over estrogen alone
8. PBX1 identified as a new pioneer factor underlying progression in breast cancer
9. Early breast cancer detection saves lives
10. Tamoxifen causes significant side effects in male breast cancer patients
11. Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with ... Latin America . ... ... ... ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: