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Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer
Date:9/25/2007

otherapy.

The researchers are using the information gained from this work to run a prospective clinical trial to test adjuvant chemotherapy in 450 patients and another trial in January 2008 for 700 patients with metastatic disease. Different chemotherapy regimens will be given, based on the patients BRCA1 levels.

Dr Rosell concluded: Our findings represent a drastic change from the currently accepted view that cisplatin-based adjuvant chemotherapy can reduce the risk of relapse in resected NSCLC patients. To the contrary, our results indicate that cisplatin will be ineffective in patients with high BRCA1 levels, though they will benefit from treatment with docetaxel or vinorelbine. The implementation of this concept in clinical practice could lead to major improvements in lung cancer treatment.


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Source:Eurekalert

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