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Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer
Date:9/25/2007

ho had received surgery for NSCLC between 2000 and 2004. In addition to BRCA1, they also looked at the expression of four other genes: nucleotide excision repair genes ERCC1 and MZF1 (myeloid zinc finger), and TRX1 (thioredoxin-1), associated with poor prognosis and TWIST1, which is involved in metastasis.

In a statistical analysis of the results, only BRCA1 and the stage of the disease emerged as independent predictors of survival: patients with high levels of BRCA1 expression had a 1.98 higher risk (i.e. nearly double) of dying within three years than did patients with low levels, while patients with advanced disease (stage IIIA) had a 7.91 higher risk (i.e. nearly eight times higher) of dying than patients with early stage disease.

Out of 77 patients with low levels of BRCA1, the majority were still alive without relapse (and therefore an average survival figure could not be calculated), but for 36 patients with high levels of BRCA1, the average event-free survival was 22 months (with a range of 14.9 to 29 months). When the average overall survival was analysed, the majority of 83 patients with low BRCA1 levels were still alive (and therefore a median average survival could not be calculated), while of 40 patients with high BRCA1 levels, average survival was 29 months.

The researchers checked these findings by examining NSCLC tumour samples from a separate group of 58 Italian patients, followed up for 40 months. They found that high BRCA1 expression in these patients increased the risk of dying by 2.4 (i.e. more than double the risk of patients with low BRCA1 expression).

Dr Rosell said: Our study showed that over-expression of BRCA1 was strongly associated with poor survival in NSCLC patients, and the validation of this finding in an independent data set from the Italian patients further strengthened this association. We suggest that patients with high BRCA1 levels will benefit from taxane-based and not cisplatin-based chem
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Contact: Emma Mason
wordmason@mac.com
34-932-308-832
ECCO-the European CanCer Conference
Source:Eurekalert

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