(Hamilton, ON) June 4, 2011 - Additional radiation treatment improves disease free survival lessening the chance of cancer recurring in women with early breast cancer who have had breast conserving surgery (lumpectomy), interim results of a new study found. The results will be presented Monday, June 6 at the annual meeting of the American Society of Clinical Oncology.
"These results are potentially practice-changing," said Dr. Timothy J. Whelan, professor of oncology at McMaster University's Michael G. DeGroote School of Medicine and lead study investigator for the NCIC Clinical Trials Group, which is funded by the Canadian Cancer Society.
In the study of more than 1,800 women with breast conserving surgery, participants received whole breast radiation (WBI) alone or WBI plus radiation to the surrounding lymph nodes called regional lymph node irradiation (RNI). Most of the women had one to three positive lymph nodes while 10 per cent had high-risk, node-negative breast cancer. All had been treated with breast-conserving surgery and adjuvant chemotherapy or endocrine therapy.
After a five-year follow-up, interim analysis of the data showed a greater than 30 per cent improvement in disease-free survival for those receiving RNI. This resulted from a 41 per cent lower rate of recurrences in the breast and lymph nodes and a 36 per cent lower rate of cancer recurrence in other parts of the body.
There was a low, but statistically significant, increased risk of moderate pneumonitis (lung inflammation) and lymphedema (excess lymphatic fluid) in the arm on the radiated side.
Whelan, division head of radiation oncology at McMaster and the Juravinski Cancer Centre and a Canada Research Chair, expects the results will encourage physicians to offer all women with node-positive disease the option of receiving regional nodal irradiation.
"Adding regional nodal irradiation improved disease-free survival, lowered the ri
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