Navigation Links
Breast cancer surgery patients benefit from adding radiation therapy
Date:6/4/2011

(Hamilton, ON) June 4, 2011 - Additional radiation treatment improves disease free survival lessening the chance of cancer recurring in women with early breast cancer who have had breast conserving surgery (lumpectomy), interim results of a new study found. The results will be presented Monday, June 6 at the annual meeting of the American Society of Clinical Oncology.

"These results are potentially practice-changing," said Dr. Timothy J. Whelan, professor of oncology at McMaster University's Michael G. DeGroote School of Medicine and lead study investigator for the NCIC Clinical Trials Group, which is funded by the Canadian Cancer Society.

In the study of more than 1,800 women with breast conserving surgery, participants received whole breast radiation (WBI) alone or WBI plus radiation to the surrounding lymph nodes called regional lymph node irradiation (RNI). Most of the women had one to three positive lymph nodes while 10 per cent had high-risk, node-negative breast cancer. All had been treated with breast-conserving surgery and adjuvant chemotherapy or endocrine therapy.

After a five-year follow-up, interim analysis of the data showed a greater than 30 per cent improvement in disease-free survival for those receiving RNI. This resulted from a 41 per cent lower rate of recurrences in the breast and lymph nodes and a 36 per cent lower rate of cancer recurrence in other parts of the body.

There was a low, but statistically significant, increased risk of moderate pneumonitis (lung inflammation) and lymphedema (excess lymphatic fluid) in the arm on the radiated side.

Whelan, division head of radiation oncology at McMaster and the Juravinski Cancer Centre and a Canada Research Chair, expects the results will encourage physicians to offer all women with node-positive disease the option of receiving regional nodal irradiation.

"Adding regional nodal irradiation improved disease-free survival, lowered the risk of recurrences, and there was a positive trend toward improved overall survival, while not greatly increasing toxicities," he said.

"For women with node positive breast cancer who are at high risk of recurrence of their breast cancer, these findings provide an important new treatment option," says Dr. Christine Williams, Director of Research, Canadian Cancer Society. "Ultimately, this finding will help more women survive and thrive after treatment."

Treatment for women with node-positive breast cancer has been breast-conserving surgery plus axillary lymph node dissection, followed by radiation to the breast (WBI). If a woman's cancer is considered high-risk, such as a tumour larger than 5 cm or more than three positive axillary nodes, she often receives RNI. However, until now, the benefit of adding RNI for women with one to three positive nodes has been unclear.


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2016)... ... ... ProBrand Reveal Volume 2 is a set of versatile and smooth logo reveals built exclusively ... can easily create a unique logo reveal in just a matter of minutes. Custom settings ... title presets to add a uniquely animated logo to any photos or videos. , ProBrand ...
(Date:4/30/2016)... ... April 30, 2016 , ... Create an abstract shape ... distort and manipulate three-dimensional shapes with ease all within Apple Motion . ... polygons, polygon texture animation, opacity texture animation, overall shape texture displacement, twist, camera ...
(Date:4/30/2016)... ... April 30, 2016 , ... Dr. Trevor Gardner, ... EMED, today signed a multifaceted agreement which will allow for the research and ... Department of Natural and Applied Sciences, Allied Health and Nursing will work together ...
(Date:4/29/2016)... ... April 30, 2016 , ... ... products, announces the Pick Up Springboard, an automotive invention that improves the storage ... industry is worth $162 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... the Accreditation Council for Graduate Medical Education (ACGME) that it has received accreditation ... the first accreditation of three residency programs that Memorial is currently pursuing, including ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016  In the next ... to shift from systems dependent on CRTs monitors to ... of modality CRT Medical monitors and will automatically ... a host of foreseeable benefits to this technological ... existing modalities have to be replaced in order ...
(Date:4/29/2016)... 29, 2016 ReportsnReports.com adds ... market research report that provides an overview of ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ... key players involved in the therapeutic development for ...
(Date:4/29/2016)... ISELIN, New Jersey , April 29, 2016 ... Omnichannel Software Suite for Life Sciences, Product Development ... and Global Life Science Customer Base . ... healthcare solutions provider, today announced the acquisition of ... is a global leader in adaptive sales enablement ...
Breaking Medicine Technology: