Navigation Links
Breast cancer subtypes originate from different biological pathways
Date:4/24/2008

There is a biological distinction between breast cancers that depend on hormones and those that do not, according to research published Friday, April 25th in the open-access journal PLoS Genetics.

Scientists previously thought that hormone dependent breast cancers, which usually require treatment with surgery and anti-hormone drugs, originated from the same biological pathway as hormone independent breast cancers, which are treated with surgery and chemotherapy.

In the largest study of its kind, an international consortium of cancer researchers studied the genetic makeup of over 23,000 breast cancer cases.*

Dr. Paul Pharoah, lead author based at the University of Cambridge, said: We looked at five genetic variants associated with breast cancer to see if they were more likely to be found in hormone dependent or independent breast cancers. One common genetic variant, FGFR2, was strongly associated with hormone dependent breast cancer, but weakly associated with hormone independent cancer. This shows that they have distinct genetic origins, and are different diseases.

Dr Lesley Walker, Cancer Research UKs director of cancer information, said: Scientists were previously unsure how different types of breast cancer developed. Although the findings wont have any immediate effects on the treatment of women with the disease, they are important in helping to define the next steps in our research on the causes of this major cancer.

This discovery provides strong evidence that the subtypes originate from separate pathways and could guide future research into prevention and treatments for the cancer types as different diseases. This study was funded by Cancer Research UK.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Page: 1

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. MRI finds breast cancer before it becomes dangerous
3. Pathway links inflammation, angiogenesis and breast cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Breast cancer prevention practices vary across Canada
6. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
7. Acrylamide Wont Raise Breast Cancer Risk
8. New link between estrogen and breast cancer
9. Hypnosis Eases Pain of Breast Cancer Surgery
10. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
11. Longaberger Expands Horizon of Hope Campaign to Build Support for American Cancer Societys Breast Cancer Initiatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... , ... “Choosing Wisdom-Solomon’s Proverbs Reclaimed”: an inspiring collection ... adultery, anger, and common sense. , “Choosing Wisdom-Solomon’s Proverbs Reclaimed” is the ... In September of 1983, they flew to Haiti to focus on missions work. ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... use to improve the connection with God. “Spiritual Vitamins: A Spiritual Energy Booster” ... Published by Christian Faith Publishing, Mathai Yohannan’s new book engages the mind and ...
(Date:1/24/2017)... ... January 24, 2017 , ... “The Octagon of Spiritual Balances”: ... Spiritual Balances” is the creation of published author, Pastor Bernard J. Weathers, pastor of ... a bachelor degree in religious education and a master degree in theology. , ““The ...
(Date:1/24/2017)... ... January 24, 2017 , ... Attention women ... article suggests that autologous fat grafting—taking one’s own fat and putting it ... breast implants. , Cosmetic Surgeon and Medical Director of MilfordMD Cosmetic Dermatology ...
(Date:1/24/2017)... ... January 23, 2017 , ... ... on Friday, January 20, with the bipartisan original co-sponsorship of nearly one-quarter of ... January 12. The National Association of Chain Drug Stores (NACDS) strongly backs the ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... 23, 2017 ArisGlobal, a leading ... announces agClinical 3.3, the latest version of its comprehensive ... science organizations to confidently and efficiently meet new compliance ... the electronic trial master file so that compliance is ... ...
(Date:1/23/2017)... , Jan. 23, 2017 Endo International ... Trade Commission (FTC) today filed a joint motion in ... California seeking the entry of ... Order resolves all disputes between the FTC and Endo ... in connection with its Opana® ER and Lidoderm® products.  ...
(Date:1/23/2017)... CLARA, Calif. , Jan. 23, 2017 /PRNewswire/ ... protection market, Frost & Sullivan recognizes Ansell, a ... Global Frost & Sullivan Company of the Year ... customer-centric approach, and a wide global footprint have ... in the hand protection market. The Company,s established ...
Breaking Medicine Technology: