Navigation Links
Breast cancer screening with MRI benefits women with radiation therapy history
Date:2/15/2011

OAK BROOK, Ill. Breast cancer screening with MRI can detect invasive cancers missed on mammography in women who've undergone chest irradiation for other diseases, according to a new study published online and in the April print edition of Radiology.

Women who receive radiation therapy as children and young adults for diseases like Hodgkin's lymphoma face a significantly greater risk of breast cancer later in life. The incidence of breast cancer increases approximately eight years after chest irradiation, and 13 percent to 20 percent of women treated with moderate- to high-dose chest irradiation for a pediatric cancer will be diagnosed with breast cancer by age 40 to 45. In comparison, the cumulative incidence of invasive breast cancer by age 45 among women in the general population is only 1 percent.

"MRI's efficacy as an adjunct to mammography in screening women at high risk because of genetic mutation or family history has been established," said the study's lead author Janice S. Sung, M.D., radiologist at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City. "However, there were no reports in the literature about utility of MRI screening in women who are at high risk specifically due to prior chest irradiation."

In the study, Dr. Sung and colleagues reviewed screening breast MRIs performed at MSKCC between January 1999 and December 2008 on women with a history of chest irradiation. They looked at data from 247 screening breast MRIs in 91 women, with a focus on the number of cancers diagnosed, the method of detection and the tumor characteristics.

Of the 10 cancers found during the study period, four were detected with MRI alone, three with MRI and mammography, and three with mammography alone. The four cancers detected with MRI alone were invasive, while the three cancers detected with mammography alone were in their early stages.

The addition of MRI to the screening process resulted in a 4.4 percent incremental cancer detection rate. A combination of MRI and mammography produced the highest sensitivity for detecting breast cancers.

"Our results support existing recommendations for annual screening MRI as an adjunct to annual mammography in women with a history of chest irradiation," Dr. Sung said.

Despite clear evidence of MRI's benefits, previous research by Dr. Sung's colleague and study co-author Kevin Oeffinger, M.D., showed that very few women ages 40 to 50 with a history of chest irradiation had undergone screening breast MRIs. Lack of awareness and limited insurance coverage are possible reasons, according to Dr. Sung. MRI is considerably more expensive than mammography.

"We hope our study and other research will bring more attention to the fact that MRI helps detect more cancers," Dr. Sung said. "We would like to see more high-risk patients undergo screening MRI."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/24/2017)... Providenciales, Turks & Caicos Islands, BWI (PRWEB) , ... September 24, ... ... Caicos Islands, the #1 rated resort on TripAdvisor and one of Provo's premier boutique ... was no reported structural damage to the resort after devastating Hurricanes Irma and more ...
(Date:9/24/2017)... ... ... I”, a young boy was walking home and feeling down about himself. He didn’t think ... new friend says he can do whatever he wants to do if he puts his mind ... he is. God created him with special talents and gifts. We see his internal dialogue ...
(Date:9/23/2017)... ... September 23, 2017 , ... ... to fighting obesity of Robert Kushner, director of Chicago’s Center for Lifestyle Medicine ... promoting healthier habits, the article notes that the center routinely recommends weight loss ...
(Date:9/22/2017)... ... 2017 , ... MEDIA OPPORTUNITY: , Save Our Hospital - Albert Lea will ... are rallying against Mayo Clinic. Specifically, media can talk to steering committee members and ... to close the Albert Lea hospital. , The rally aims to protect the most ...
(Date:9/22/2017)... ... 2017 , ... Fenwick Agency of Plano, TX has announced the commencement of ... the nationally recognized ‘Agents of Change’ movement. The agency pledges to select a new ... seek out those who most need help. Their hope is to bring awareness to ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... -- Robert G. Szewc, M.D., is recognized by Continental Who,s ... his contributions to the Medical field.      ... practice of Kidney and Hypertension Specialists, which specializes in ... He has worked in this position since 2002, and ... as expertise in kidneys, hypertension, chronic disease and anemia, ...
(Date:9/6/2017)...   PDI , a leader in infection prevention ... educational session focused on the role of chlorhexidine gluconate ... the 2017 Annual Scientific Meeting of the Association for ... the Phoenix Convention Center in ... will also feature PDI,s Prevantics® Device Swab ...
(Date:9/6/2017)... Sept. 6, 2017 Eli Lilly and Company ... present new data for galcanezumab and lasmiditan, two investigational ... International Headache Society (IHC) taking place Sept. 7-10 in ... will highlight new, long-term data from an open-label study ... galcanezumab (120 mg and 240 mg) for the prevention ...
Breaking Medicine Technology: