Navigation Links
Breast cancer risk varies among different progestins used in hormone replacement therapy
Date:8/10/2010

COLUMBIA, Mo. Progestins are used in hormone replacement therapies to counteract the negative effects of estrogen on the uterus and reduce the risk of uterine cancer. However, evidence in recent studies and clinical trials has demonstrated that progestins increase the risk of breast cancer. Now, University of Missouri researchers have compared four types of progestins used in hormone replacement therapies and found significantly different outcomes on the progression of breast cancer in an animal model depending on the type of progestins used.

"Synthetic progestins have different biological effects, due to differences in their structure, stability and how they interact in the body," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center. "Clinical use of progestins requires caution. These powerful steroids should only be prescribed when a person has no latent, or dormant, cancer and does not have a family history of cancer. However, it is difficult to diagnose latent tumor cells in women since there are no symptoms."

In the study, researchers compared the effects of four clinically relevant progestins on breast cancer tumors in an animal model. The progestins used in the study were the synthetic progestin medroxporgresterone acetate (MPA), norgesterel (N-EL), norethindrone (N-ONE) and megestrol acetate (MGA). In the United States, most women on hormone replacement therapy are treated with MPA, the progestin in Prempro, Hyder said.

"Although previous studies using an animal model for breast cancer found that MPA functions as a tumor promoter, this study show that N-EL and N-One, when administrated using the same protocol as used for MPA, strongly inhibited tumor development," Hyder said. "Thus progestins seem to have tumor-stage specific effects, which determine whether these will function as tumor promoters or tumor
'/>"/>

Contact: Steven Adams
adamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... "Mississippi baby" an infant seemingly cured of HIV that was ... HIV infection in The New England Journal of Medicine ... than two years of not taking antiretroviral therapy without evidence ... involved in the case. , "Certainly, this is ... medical staff involved in the child,s care, and the HIV/AIDS ...
(Date:7/10/2014)... For those students looking to bump up their grade ... spending more time in a library or study hall, ... research shows that students who were members of the ... their freshman and sophomore years had higher GPAs than ... that students with memberships stayed in school longer. An ...
(Date:7/10/2014)... of medical imaging far outweigh the risks when children ... The Right Radiation Dose. However, overuse and misuse of ... leading a collaborative effort to ensure a national protocol ... the Journal of Patient Safety , calls for ... Intersociety Accreditation Commission, and the Centers for Medicare & ...
(Date:7/10/2014)... Many studies have shown that more severe illness and ... a secondary respiratory infection after developing influenza. Now, however, ... has determined that if you reverse the order of ... pneumococcus) may actually protect against a bad case of ... bacterial protein pneumolysin, which is described as a bacterial ...
(Date:7/10/2014)... the human brain operates much the same whether active ... a better understanding of schizophrenia, bipolar disorder and other ... million Americans. , In newly published research in the ... at the Center for Molecular and Behavioral Neuroscience, determined ... rest is basically the same as that of a ...
Breaking Medicine News(10 mins):Health News:'Mississippi Baby' now has detectable HIV, researchers find 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 3Health News:Want a higher GPA in college? Join a gym 2Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:Bacterial colonization prior to catching the flu may protect against severe illness 2Health News:Working to loosen the grip of severe mental illness 2
... such as high blood sugar and insulin, and low ... predict whether a woman will develop diabetes during a ... the current issue of the American Journal of ... of all women before pregnancy, particularly overweight women, could ...
... at Chicago are the first to use brain imaging ... function in children with pediatric bipolar disorder or attention ... the October issue of the Journal of the ... PBD and ADHD are very severe developmental disorders that ...
... has been the subject of many studies since its ... unclear picture of XMRV,s role in human disease. In ... of The Journal of Infectious Diseases , now ... XMRV and prostate cancer but not other links involving ...
... Nuclear Medicine (SNM) and the Society for Pediatric ... American Guidelines for Radiopharmaceutical Doses for Children. These ... by standardizing doses (based on body weight) for ... The Alliance for Radiation Safety in Pediatric Imaging ...
... HealthDay Reporter , TUESDAY, Oct. 12 (HealthDay News) -- Women ... breast cancer, even if a close relative has had the ... activity, maintaining a healthy weight and drinking alcohol in moderation, ... help protect against breast cancer in postmenopausal women, the researchers ...
... HealthDay Reporter , TUESDAY, Oct. 12 (HealthDay News) -- ... drugs such as Aredia or Zometa to reduce or delay ... the irregular heartbeat known as atrial fibrillation and for a ... of the heart beat chaotically, causing blood to pool and ...
Cached Medicine News:Health News:Metabolic status before pregnancy predicts subsequent gestational diabetes 2Health News:Brain imaging identifies differences in childhood bipolar disorder, ADHD 2Health News:New studies examine links between XMRV and human disease 2Health News:New studies examine links between XMRV and human disease 3Health News:SNM and Image GentlyTM launch initiative to standardize radiation dose in pediatric nuclear medicine 2Health News:SNM and Image GentlyTM launch initiative to standardize radiation dose in pediatric nuclear medicine 3Health News:Three Healthy Habits Cut Breast Cancer Risk, Study Finds 2Health News:Three Healthy Habits Cut Breast Cancer Risk, Study Finds 3Health News:Cancer-Fighting Bone Drugs Might Raise Stroke Risk 2Health News:Cancer-Fighting Bone Drugs Might Raise Stroke Risk 3
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
(Date:1/15/2014)... Jan. 15, 2014 Massachusetts General Hospital (MGH), ... AMGN ) announced today that they have launched ... new therapeutic targets and develop novel therapies for ... affects millions worldwide. The MGH-Broad-Amgen collaboration brings together ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... NEW YORK, Jan. 12, 2011 InstaCare Corp. ... prescription and non-prescription diagnostics, home testing products for ... direct to patient diabetes programs, and a leading ... technologies, today announced that the company,s Board of ...
... 2011 At the 29th Annual J.P. Morgan Healthcare Conference, ... that based on a preliminary review of 2010 results, it ... more than $3.5 billion compared to 2009. Adjusted cash earnings ... the midpoint of the company,s latest forecast of $3.37 to ...
Cached Medicine Technology:InstaCare Corp. Announces 2011 Genstrip Guidance Report Penned by William Walling, CFA 2Watson Announces Preliminary Financial Performance for FY 2010 2Watson Announces Preliminary Financial Performance for FY 2010 3Watson Announces Preliminary Financial Performance for FY 2010 4
Storage temperature: 2 - 8C, linearity: 0 - 25 mg/dL, expected value: male: 3.5 - 7.0 mg/dL and female: 2.5 - 6.0 mg/dL. Available with calibrator and number of test 500....
Storage temperature: 15 - 30C, linearity: 0 - 20 mg/dL, expected value: male: 3.0 - 7.0 mg/dL and female: 2.2 - 6.2 mg/dL. Available with calibrator and number of tests 125....
The assay kit is for determination of uric acid in serum or urine. Wavelength: 600 nm. Linear range: up to 80 mg/dL....
Intended for the quantitative determination of uric acid in serum or plasma. Reaction: endpoint. Wavelength: 520 nm. Linearity: 20 mg/dL (1190 mol/L). Single vial, dry powder reagent....
Medicine Products: