Navigation Links
Breast cancer risk prediction model for African American women underestimates risk
Date:2/15/2013

(Boston) A breast cancer risk prediction model developed for African Americans tends to underestimate risk in certain subgroups, according to a new study from the Slone Epidemiology Center (SEC) at Boston University. The model predicted estrogen receptor (ER)-negative breast cancer, which is a more aggressive form of breast cancer that disproportionately affects African American women, more poorly than ER-positive breast cancer.

The study, published online today in the Journal of the National Cancer Institute, was led by Deborah Boggs, ScD, postdoctoral associate at Slone and the study's corresponding author.

The Breast Cancer Risk Assessment Tool, also known as the Gail model, is used to estimate a woman's breast cancer risk and to determine eligibility for breast cancer prevention trials. The Gail model was developed based on data from white women but has been found to underestimate breast cancer risk in African American women. Researchers had previously modified the Gail model using data from African American women in the Women's Contraceptive and Reproductive Experiences (CARE) study and had validated the CARE model among postmenopausal African American women between the ages of 50 and 79.

In this study, researchers tested the CARE model among both premenopausal and postmenopausal women using data from the Black Women's Health Study (BWHS), an ongoing follow-up study of 59,000 African American women from across the U.S. The investigators focused on 45,942 women who were 30 to 69 years old and free of cancer at the beginning of the study. They found that the CARE model accurately predicted the number of breast cancers that would occur among women who had given birth before the age of 25 but was a less accurate predictor among women who first gave birth at a later age, underestimating the number of breast cancers in this group by 29 percent.

Whereas a woman's age at first birth is used in the Gail model for white
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Copper depletion therapy keeps high-risk triple-negative breast cancer at bay
2. Researchers discover biological diversity in triple-negative breast cancer
3. Lung cancer set to overtake breast cancer as the main cause of cancer deaths among European women
4. Breast Cancer Research Needs More Focus on Environment: Report
5. ForeCYTE Delivers Blow in the War Against Breast Cancer
6. Rooting out recurrent breast cancer
7. Breast-Feeding Still Less Common for Black Babies: CDC
8. Breast milk reduces risk of sepsis and intensive care costs in very-low-birth-weight infants
9. University of Minnesota researchers discover enzyme behind breast cancer mutations
10. MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients
11. Early breast cancer diagnosis, survival rates low in rural India
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... A new study of self-awareness by Kessler ... (MS) may be able to improve their self-awareness ... ahead of print on July 2 in ... Nancy D. Chiaravalloti & John DeLuca: Metacognitive knowledge ... doi: 10.3233/NRE-141113). Self-awareness is one,s ability to recognize ...
(Date:8/22/2014)... attained the distinguished Magnet hospital designation by the ... Considered the gold standard for nursing excellence, the ... professionalism. It is the top international credential for ... Newport Hospital was based on the hospital,s continued ... , "It is a privilege for us to ...
(Date:8/22/2014)... Counseling may do little to help young people with ... 66 studies that included nearly 18,000 people 25 and ... drinking problems. Participants in 49 studies attended a single ... the studies attended group sessions or a mix of ... motivational interviewing was used in the studies. This technique ...
(Date:8/22/2014)... treatments have become available for key subtypes of ... treatments can be pre-identified by looking for defined ... whose lung cancer is driven by rearrangement of ... drug crizotinib, which targets this abnormality. Many ongoing ... success by matching different drugs with specific subtypes ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 ItsHot.com, a ... now offering 60-80% off on its range of beautiful ... the purchase of Gold Hearts 14K White Rose Gold ... a discount of 77%. Previously priced at $3,715.00, ... $859.00. The item code of this mesmerizing pendant embedded ...
Breaking Medicine News(10 mins):Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2Health News:Newport Hospital receives nursing's highest credential for third time with Magnet recognition 2Health News:Counseling Does Little to Deter Youth Drinking, Review Finds 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 3Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 4Health News:ItsHot.com Now Offers 60-80% Discount on its Striking Collection of Diamond Heart Pendants 2
... new study reveals that almost two-thirds of US ... life, but very few of them experience post-traumatic ... emotional resilience in children, but it also suggests that ... adults, said William Copeland of Duke University Medical Center, ...
... Mayfield Dairy Farms announced today that it is voluntarily recalling ... a code date of 4/11/08 and a UPC code ... contains peanuts, which are not listed on the label. No ... ,Some individuals with allergies to peanuts run the ...
... Higher Colon Cancer Risk in Uveal Melanoma Patients and ... by Frederick H. Davidorf, MD, during the Association ... Meeting in Fort Lauderdale, Fla. ,The presentation ... p.m. to 4:45 p.m. in Hall B/C of the ...
... brown widow spider, a cousin to the well-known black widow, ... ,It is belongs to a group that is officially ... referred to as "fiddleback" spiders or "violin" spiders because of ... (fused head and thorax). ,The spiders are generally ...
... to over 76.6 million people over the age of 60. ... ministry, the country has 76,622,321 persons aged 60 and above. ... Uttar Pradesh tops the chart with 11.6 million elderly. ... has 5.7 million, Bihar and Tamil Nadu have 5.5 million ...
... Ministry of External Affairs, informed the Lok Sabha today that ... passports. ,At first these passports will be ... the end of 2007. Based on the experience gained from this ... the ordinary category by the end of 2008. , ...
Cached Medicine News:Health News:Two-thirds of US Children Experience Trauma, but Recover Fast 2Health News:Louisiana Residents Warned Against Brown Recluse Spiders 2
(Date:8/22/2014)... -- Landauer, Inc. (NYSE: LDR ), a recognized ... outsourced medical physics services and high quality medical consumable ... its President and Chief Executive Officer, will be stepping ... a member of the Board of Directors, effective as ... an interim basis by Michael T. Leatherman , ...
(Date:8/21/2014)... GREENWICH, Conn. , Aug. 21, 2014 /PRNewswire/ ... West Lafayette, Indiana , has ... determination and characterization of small and large molecules, ... addition of the Bruker maXisPlus Q-TOF mass spectrometer. ... Jonathan Goldman , CEO, Aptuit, said, "The expanded ...
(Date:8/21/2014)... DEERFIELD, Ill. , Aug. 21, 2014 /PRNewswire/ ... reports Baxter International Inc. today announced positive results ... BAX 855, an investigational, extended half-life recombinant factor ... ADVATE [Antihemophilic Factor (Recombinant)], which met its primary ... the prophylaxis arm compared to the on-demand arm. ...
Breaking Medicine Technology:Landauer, Inc. Announces Executive Management Change 2Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5
... , LONDON , January 19 The ... later today. , The ShelterBox Response Team of David ... have been in Haiti,s capital since Thursday, took,delivery of the first ShelterBoxes ... twelve of these boxes will be used to build an emergency,field hospital at the ...
... , THE WOODLANDS, Texas , Jan. 19 ... changing its name to the Life Beyond Cancer Foundation. This new ... to provide to cancer patients and their families. , The ... removing barriers to prevention, education, early detection, treatment and survivorship. Cancer ...
Cached Medicine Technology:First ShelterBoxes Arrive in Port au Prince - Pictures and Footage 2US Oncology Foundation Becomes Life Beyond Cancer Foundation 2US Oncology Foundation Becomes Life Beyond Cancer Foundation 3
The CSV-1000ETDRS10% test face presents the standard ETDRS test at a contrast level of 10%. This test is widely used in clinical studies for the evaluation of refractive surgery and contact lenses....
... The CSV-1000S test face is widely used ... evaluation. This test presents standard visual acuity from ... (6 and 12 cycles/degree) and a real-world driver's ... cataract documentation as it provides a standard acuity ...
Contrast sensitivity testing, glare sensitivity testing and ETDRS acuity testing are provided in the self standardized CSV-1000 instrument. Patented photocell circuitry automatically monitors and cal...
... those involved with healthcare decisions to keep ... evidence in their field of interest - ... as the volume of evidence increases. Cochrane ... best single source available for continually updated ...
Medicine Products: