Navigation Links
Breast cancer risk prediction model for African American women underestimates risk

(Boston) A breast cancer risk prediction model developed for African Americans tends to underestimate risk in certain subgroups, according to a new study from the Slone Epidemiology Center (SEC) at Boston University. The model predicted estrogen receptor (ER)-negative breast cancer, which is a more aggressive form of breast cancer that disproportionately affects African American women, more poorly than ER-positive breast cancer.

The study, published online today in the Journal of the National Cancer Institute, was led by Deborah Boggs, ScD, postdoctoral associate at Slone and the study's corresponding author.

The Breast Cancer Risk Assessment Tool, also known as the Gail model, is used to estimate a woman's breast cancer risk and to determine eligibility for breast cancer prevention trials. The Gail model was developed based on data from white women but has been found to underestimate breast cancer risk in African American women. Researchers had previously modified the Gail model using data from African American women in the Women's Contraceptive and Reproductive Experiences (CARE) study and had validated the CARE model among postmenopausal African American women between the ages of 50 and 79.

In this study, researchers tested the CARE model among both premenopausal and postmenopausal women using data from the Black Women's Health Study (BWHS), an ongoing follow-up study of 59,000 African American women from across the U.S. The investigators focused on 45,942 women who were 30 to 69 years old and free of cancer at the beginning of the study. They found that the CARE model accurately predicted the number of breast cancers that would occur among women who had given birth before the age of 25 but was a less accurate predictor among women who first gave birth at a later age, underestimating the number of breast cancers in this group by 29 percent.

Whereas a woman's age at first birth is used in the Gail model for white women, this factor is not used in the CARE model for African American women. The researchers conclude that age at first birth may be an important factor to include in a risk model for African American women in order to better predict breast cancer risk for women with a later age at first birth.

The authors also found that the CARE model, similar to other breast cancer risk prediction models, is not a reliable tool to predict a woman's individual risk of developing breast cancer. Additionally, it was less effective at predicting, at the individual level, ER-negative breast cancer than ER-positive breast cancer.

The authors conclude that there is a need to develop a better risk model for ER-negative breast cancer, a subtype that is associated with a poorer prognosis than ER-positive tumors and that is more commonly diagnosed in African American women than in white women.


Contact: Gina DiGravio
Boston University Medical Center

Related medicine news :

1. Copper depletion therapy keeps high-risk triple-negative breast cancer at bay
2. Researchers discover biological diversity in triple-negative breast cancer
3. Lung cancer set to overtake breast cancer as the main cause of cancer deaths among European women
4. Breast Cancer Research Needs More Focus on Environment: Report
5. ForeCYTE Delivers Blow in the War Against Breast Cancer
6. Rooting out recurrent breast cancer
7. Breast-Feeding Still Less Common for Black Babies: CDC
8. Breast milk reduces risk of sepsis and intensive care costs in very-low-birth-weight infants
9. University of Minnesota researchers discover enzyme behind breast cancer mutations
10. MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients
11. Early breast cancer diagnosis, survival rates low in rural India
Post Your Comments:
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: