Navigation Links
Breast cancer risk amplified by additional genes in combo with BRCA mutation
Date:4/16/2008

PHILADELPHIA - Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra risk-amplifying genes, according to research published this month in the American Journal of Human Genetics.

Researchers at the University of Pennsylvania School of Medicine join an international consortium of research groups that looked at more than 10,000 women carrying a BRCA1 or BRCA2 mutation for breast-cancer risk.

These results suggest that knowledge of a BRCA1 or BRCA2 mutation is necessary, but not sufficient, to fully understand cancer risk in women who carry these mutations, says co-author and head of the North American coalition Timothy R. Rebbeck, PhD, Professor of Epidemiology at Penn. This paper demonstrated that other genes, and possibly exposures, could provide important information that may refine our ability to predict cancer in this high-risk population. Because carriers of BRCA1 or BRCA2 mutations are relatively rare in the population, the only way to undertake studies of this type is by forming large consortia. Rebbeck is also the Associate Director for Population Science at Penns Abramson Cancer Center.

This is the first time we have found evidence that common changes in other genes can amplify the risk of breast cancer in women known to have faulty BRCA genes, says lead author Professor Doug Easton, director of Cancer Research UKs Genetic Epidemiology Unit at the University of Cambridge. This is the first step in finding a set of genes that modify the risk in BRCA carriers, and may influence how we monitor women with a family history of the disease.

The international team of scientists have found that common versions of two genes FGFR2 and TNRC9 known to increase breast cancer risk in the general population also increase the risk in women carrying damaged versions of the BRCA2 gene.

Around one in eighteen women will develop breast cancer by the age of 65. On average, half of wome
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research collaboration seeks blood test for aggressive breast cancer
2. MRI before surgery leads to better-adapted treatment for breast cancer
3. Obese women disadvantaged in both breast cancer treatment and diagnosis
4. Hereditary breast cancer -- a high cost to patient and health care provider alike
5. Tracking and feedback registry helps reduce disparities in breast cancer care
6. Breast Cancer Unchanged in Black Women, Despite Drop in HRT Use
7. Study finds media coverage of breast cancer focuses too little on prevention
8. Detecting, Diagnosing Breast Cancers
9. NovoCure presents results from breast cancer pilot study
10. OHSU Cancer Institute researchers find connection between protein, prognosis in breast cancer
11. Drinking May Raise Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... LunaDress has recently announced its 2015 collection of ... on all of its special occasion dresses & wedding apparel. ... wedding gown. If you have no idea of what to ... different wedding dress styles and our dress experts are here ... current special offer, up to 80% off," the CEO of ...
(Date:12/20/2014)... holidays can be anything but joyous for people with ... and other allergy triggers. "The dust from the ... away in dank basements or dusty attics is triggering ... Shah, an affiliate faculty member at Loyola University Chicago ... Shah, who is also an allergist at Gottlieb ...
(Date:12/20/2014)... Angeldress.co.uk, the distinguished wedding dress manufacturer and retailer, has ... company has recently updated its official blog with the ... Angeldress Blog has recommended some new designs ... itself in offering a huge selection of elegant products ... outfits are very carefully selected based on the design ...
(Date:12/20/2014)... 2014 The aftermath of the November 24th ... not only in Hollywood, but worldwide. As reported ... ripples of that attack are starting a finger-pointing game which ... But they are not the only ones affected, regular ... for some embarrassing times ahead, agents and lawyers could be ...
(Date:12/20/2014)... Xarelto bleeding lawsuits filed by men ... and other serious side effects will be consolidated in ... coordinated pretrial proceedings, Wright & Schulte LLC reports. The ... order Friday to transfer 21 Xarelto lawsuits and over ... to the Louisiana district court for coordination by Judge ...
Breaking Medicine News(10 mins):Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:Holiday Trimmings Can Trigger Allergies 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4
... 2009 - In a study by Miall, Gowen and Tchalenko ... ( http://www.elsevier.com/locate/cortex ), a brain scanner was used to ... of drawing faces. The researchers found that the captured visual ... plans to reach those locations. It is as if the ...
... April 1-5, 2009 at Marriott Wardman Park ... Osteoporosis Foundation (NOF) will bring together a ... relevant evidence-based information on bone health and ... of healthcare professionals at its comprehensive annual ...
... the Nebraska Medical AssociationOMAHA, Neb., March 19 With ... three months, it,s time for those who smoke to ... so on Wednesday, March 25, when school children throughout ... sponsored by the Campaign for Tobacco Free Kids. ...
... Increasing Sales of the Company,s Innovative Revenue Cycle ... charge capture technologies, today announced that it has ... led by existing investor Boston Millennia Partners. This ... growth of its Intelligent Charge Capture suite of ...
... Eating out, lack of social support and high-risk lifestyles ... with type 2 diabetes from controlling their condition, according ... 4,550 healthcare providers from 28 countries. , The ... Journal of Nursing and Healthcare of Chronic Illness , ...
... Field Museum for World Water Day March 22 CHICAGO, ... product safety testing services, will launch its water quality and ... Museum, 1400 S. Lake Shore Drive in Chicago, from 10:00 ... As part of the organization,s century-long commitment to public health ...
Cached Medicine News:Health News:The brain 'joins the dots' when drawing a cartoon face from memory 2Health News:Latest Osteoporosis Research Translated for Health Professionals to Use in Clinical Setting 2Health News:Kick Butts Day a Timely Prelude to Nebraska's June 1 Smoking Ban 2Health News:MedAptus Secures $6 Million Investment 2Health News:Barriers to diabetes care include restaurants and high-risk lifestyles, says international review 2Health News:Barriers to diabetes care include restaurants and high-risk lifestyles, says international review 3Health News:World Water Day 2009 Marks Launch of UL's Yearlong Commitment to Water Quality and Conservation Education 2Health News:World Water Day 2009 Marks Launch of UL's Yearlong Commitment to Water Quality and Conservation Education 3
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between ... hearing health was forgotten. But Audicus , a ... hear better this new year. Hearing loss ... the aging population, though it is often unaddressed. Forty-eight ... four has a hearing aid, mainly due to price. ...
(Date:12/19/2014)... CITY, Calif., Dec. 18, 2014 Capnia, ... the development of medical diagnostics based on its ... gas flow, today announced financial results for the ... 2014. "Following the completion of our ... positioned to maximize the recently initiated CoSense® commercial ...
(Date:12/19/2014)... , Dec. 18, 2014   Aratana Therapeutics, ... biopharmaceutical company focused on the licensing, development and ... announced positive results from its pivotal field study ... treating pain in dogs with osteoarthritis.  In the ... assessment scores that were statistically significant compared to ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... , , , ... majority-owned subsidiary of Speedus Corp. (Nasdaq: SPDE ), ... the U.S. FDA, has cleared the Zargis Cardioscan(TM) device ... analysis software connects wirelessly to a Bluetooth®-enabled electronic stethoscope ...
... NATICK, Mass., Jan. 8 Boston Scientific Corporation (NYSE: ... from the Japanese Ministry of Health, Labor and Welfare (MHLW) ... treatment of coronary artery disease. The Company plans to ... which is expected in the coming weeks. , The PROMUS ...
Cached Medicine Technology:Zargis Cardioscan Cleared for Sale in Canada 2Zargis Cardioscan Cleared for Sale in Canada 3Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 2Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 3Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 4
... nebulizer system offers an affordable and ... COPD or other respiratory conditions. The ... gives patients the ability to take ... Its unique nebulizer design delivers powerful ...
Pediatric Compressor Nubulizer...
... very popular and competitively priced SportNeb ... compressor. Design enhancements include a neb ... optional black carry bag. The color ... The SportNeb also offers private labeling ...
... is an important part of managing the ... convenient products mean delivering the aerosolized medication ... while minimizing medication waste. Aerosol delivery with ... of Nebulizers, including the new NebuTech® HDN®, ...
Medicine Products: