Navigation Links
Breast cancer replicates brain development process
Date:4/24/2014

New research led by a scientist at the University of York reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.

A research team, led by Dr Will Brackenbury, a Medical Research Council Fellow in the Department of Biology at York, has studied how voltage-gated sodium channels assist in the metastasis of cancerous tumours. These channels are found in the membranes of excitable cells, such as neurons, where they are involved in transmission of electrical impulses. However, the channels have also been found in metastatic cancer cells.

Using clinical breast cancer specimens from the Breast Cancer Campaign Tissue Bank and preclinical laboratory modelling, the researchers, including Dr Rebecca Millican-Slater, a consultant pathologist at St James University Hospital, Leeds, discovered that a sodium channel protein called Beta-one is present at high levels in breast cancer samples compared with normal tissue.

In research published in the International Journal of Cancer, they show for the first time that the increase in beta-one protein levels make tumours grow faster. They also discovered that Beta-one proteins play a significant role in enabling the cells to change shape and move, and consequently metastasise.

Understanding these processes is important in understanding cancer metastasis. Although the number of deaths from breast cancer is decreasing, it is still the leading cause of cancer-related death in women because of metastasis.

Dr Brackenbury said: "While there is no cure for metastasis, blocking the sodium channels inhibits migration and invasiveness and it may therefore be a viable therapeutic target. What is most exciting is that the mechanism by which Beta One regulates migration appears to replicate what it does in the central nervous system.

"As well as regulating electrical activity in neurons, Beta-one also regulates the migration of neurons during brain development and the breast cancer signalling mechanism seems to be the same. A process that is important in the development of the nervous system is being co-opted to play an insidious role in tumour development."

This research was funded by the Medical Research Council.

Baroness Delyth Morgan, Chief Executive at Breast Cancer Campaign, said: "The Breast Cancer Campaign Tissue Bank is vital for enabling researchers to use good quality tissue samples in their research. Dr Brackenbury's findings demonstrate how the Tissue Bank is helping drive forward research and new discoveries into what could be causing breast cancer to spread."


'/>"/>
Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York
Source:Eurekalert

Related medicine news :

1. Gold nanoparticles help target, quantify breast cancer segments in a living cell
2. Benaroya Research Institute evaluates immunology approach to blocking breast cancer
3. First genetic link discovered to difficult-to-diagnose breast cancer sub-type
4. Low birth weight, less breastfeeding create later health risks
5. Increased risk of developing lung cancer after radiotherapy for breast cancer
6. Novel study into breast cancer origins paves way for personalized treatment
7. Texas researcher: Peaches inhibit breast cancer metastasis in mice
8. Researchers issue state-of-the-state on genetic-based testing and treatment for breast cancer
9. Twenty-five percent of breast cancer survivors report financial decline due to treatment
10. Gene implicated in progression and relapse of deadly breast cancer finding points to potential Achilles heel in triple negative breast cancer
11. Deaths from breast cancer fall in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... Mass. , June 24, 2016   ... Spaulding Rehabilitation Network,s Dean Center for Tick ... Physical Medicine and Rehabilitation, MIT Hacking Medicine, University ... for Innovation, today announced the five finalists of ... for Lyme disease.  More than 100 scientists, clinicians, ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
Breaking Medicine Technology: