Navigation Links
Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
Date:4/5/2010

ence and risk of contralateral breast cancer among women in the general population who carry mutations in BRCA1 and BRCA2.

Previous research on these genes in relation to the risk of contralateral breast cancer has focused largely on rare, high-risk families and has been constrained by small numbers of cases.

"While contralateral breast cancer risks in our study are quite substantial, it is worth noting that they are also 10 percent to 15 percent lower overall than in past studies in high-risk settings," Malone said. One reason for this, she said, is because this study is among the few to assess risk among substantial numbers of women without a positive family history of breast cancer.

"Getting these risk estimates right is important because of their role in clinical decision-making," Malone said. "Our study is the first to include the full spectrum of family history profiles, from minimal to extreme risk, and thus is likely to more accurately reflect the true risk of contralateral breast cancer among BRCA carriers in the general population," she said.

More than 180,000 U.S. women are diagnosed with breast cancer annually. "With growing numbers of breast cancer survivors nationwide, the magnitude of the burden associated with the potential risk of second primary contralateral breast cancer is quite large," Malone said.

BRCA1 and BRCA2 belong to a class of genes known as tumor suppressors. These genes help ensure genetic integrity of the cell and help prevent uncontrolled cell growth that can lead to cancer. Mutation of these genes has been linked to the development of hereditary breast and ovarian cancer.

A woman's lifetime risk of developing breast and/or ovarian cancer is greatly increased if she inherits a mutation in either of these genes. Such a woman has an increased risk of developing breast and/or ovarian cancer at an early age (before menopause) and often has a number of close family members who have been diagnosed with these
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. Carol Milgard Breast Center Awarded Highest Government Rating for Mammography Sites
5. Prolactin blocks oncogene associated with poor prognosis in breast cancer
6. Definitive study confirms chemo benefit in postmenopausal breast cancer
7. Adding Chemo to Tamoxifen Helps Some Breast Cancer Patients
8. Major New Study Finds Soyfoods Safe and Beneficial for Women With Breast Cancer
9. Bone Drugs May Beat Back Breast Cancer
10. California Breast Cancer Survivors and Advocates Call on State to Nix Screening Cuts
11. Alcohol consumption may increase breast cancer recurrence risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Grove Village, IL (PRWEB) August 29, 2014 ... Kathleen Baty, “The Safety Chick” who profiled a ... ETY•Kids® Safe-Listening Earphones from Etymotic Research. This year, ... supply list, and Etymotic, an innovator of hearing ... young ears. Their ETY•Kids Safe-Listening Earphones, offered in ...
(Date:8/29/2014)... The microbiology testing sector is one of the ... is also the hugest challenge facing suppliers during these ... of AIDS – still the world’s key health threat ... opportunistic infections (OIs); bioterrorism threat; advancements in technologies for ... Although for certain infections the etiology remains a mystery, ...
(Date:8/29/2014)... Virginia Beach, VA (PRWEB) August 29, 2014 ... of the top ten tools for online teaching, as ... Award for Best Course or Learning Management System, announced ... Center of America, Metis Leadership Group, Interactive Advertising Bureau ... to the user community. , “We are delighted to ...
(Date:8/29/2014)... August 30, 2014 Top10inaction, a professional ... conference providers in the online service industry for the ... global leaders Webex, GotoMeeting and Infinite. , With over ... have to determine which provider is ideally a good ... businesses search for compelling consumer goods and services agencies ...
(Date:8/29/2014)... 29, 2014 After having a double ... had to have breast reconstruction. She found that the ... she decided that there needed to be a solution. ... a woman or man who needs or wants breast ... promotes confidence and peace of mind. Producible in design ...
Breaking Medicine News(10 mins):Health News:The Today Show Features ETY•Kids® Safe-Listening Earphones by Etymotic 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 3Health News:Edvance360 Continues to Experience Growth in Corporate, K-12, Health, and Non-Profit Sectors 2Health News:Top10InAction Reveals Best Web Conference Providers 2
... are conducted periodically to check fitness in students. Jack ... year's results of the annual assessment of fifth, seventh ... the fifth, seventh and ninth graders and studies student ... the test this year. Only one-third could meet the ...
... dangerous information available on the internet is causing eating ... // ,The NHS Quality Improvement Scotland (NHS ... have been increasing the dangers faced by thousands of ... ,The first ever guidelines have been issued ...
... attacks are less likely to have properly managed the ... quality of life, a new study finds. ... Health Cooperative in Seattle, said her group's previous work ... more diabetes symptom, and lower functioning. 'But because panic ...
... ON HEART IN CHILDREN // ,For children, even mild ... enlargement of the heart, according to results of a study ... Children's Hospital at Montefiore in Bronx, New York. ... higher the blood pressure the worse the strain on the ...
... UK opine that new measures have to be considered to ... comprehensive immunization from the health officials in India, almost one-third ... ,According to the experts in UK, the ... to improper sanitation and congestion of living space. These obstacles ...
... that he proposed to introduce a bill that would ... bill is better known as "Texas Smoke-Free Workplace Law." ... be banned under legislation. ,Ellis made his announcement on the ... Great American Smokeout. ,"Even though cities all over ...
Cached Medicine News:Health News:Internet Health Advice Causing More Harm than Good 2Health News:Panic Attacks Can Increase Complications in Diabetes Patients 2Health News:Children and Chronic Kidney Disease 2Health News:Children and Chronic Kidney Disease 3Health News:Polio can be eradicated in India: Health Experts 2
(Date:8/29/2014)... , August 29, 2014 Pixcelldata, ... collaboration software has announced a major new deal with ... by renowned pathology expert, Dr. Marius Nap . ... the 26th European Congress of Pathology which is taking ... ExCeL Arena, London where Pixcelldata ...
(Date:8/28/2014)... WILMINGTON, Del. , Aug. 28, 2014  Rigrodsky & Long, ... shares of Lannett Company, Inc. (NYSE: LCI )? , ... between September 10, 2013 and July 16, 2014, inclusive? , ... Inc.? , Do you want to discuss your rights? ... former Special Assistant United States Attorney, Timothy J. MacFall , ...
(Date:8/28/2014)... 28, 2014  Decision Resources Group finds that ... strongly through 2022 at a compound annual growth ... largely supported by strong population growth and a ... imaging procedures. The Indian government,s greater investment in ... purchase or upgrade diagnostic imaging equipment. ...
Breaking Medicine Technology:Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 2Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 3
... NEW YORK, Dec. 2 Keryx Biopharmaceuticals, Inc. (Nasdaq: ... and Drug Administration (FDA) has granted Fast Track designation ... anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, ... , The Fast Track program of the FDA is ...
... BIRMINGHAM, Ala., Dec. 2 Adults are more likely to ... over, the odds of losing vision are one in three, whereas the ... odds of a woman developing breast cancer are one in nine. ... risk of injuries, depression and inability to complete daily tasks. , Vision ...
Cached Medicine Technology:Keryx Receives FDA Fast Track Designation for KRX-0401 (Perifosine) for the Treatment of Relapsed/Refractory Multiple Myeloma 2Keryx Receives FDA Fast Track Designation for KRX-0401 (Perifosine) for the Treatment of Relapsed/Refractory Multiple Myeloma 3Keryx Receives FDA Fast Track Designation for KRX-0401 (Perifosine) for the Treatment of Relapsed/Refractory Multiple Myeloma 4Risk of Vision Loss in Aging Adults is Greater Than Risk of Breast or Prostate Cancer 2
Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer s...
pHix Strips easily fix the catheter on the nose and are made of microporous tape allowing the skin to breathe....
... designed using established technology providing a ... ,Working with pH catheters with ... multi-use catheter is used the Hellige ... the skin.,NOTE: ,Medtronic pH measurement systems ...
... single-use pH catheters are efficient, economical, ... allow greater patient comfort during the ... measurement systems have been designed to ... an accurate room-temperature calibration. The temperature ...
Medicine Products: