Navigation Links
Breast cancer patients with BRCA gene diagnosed almost 8 years earlier than generation before
Date:9/11/2011

Houston, TX Women with a deleterious gene mutation are diagnosed with breast cancer almost eight years earlier than relatives of the previous generation who also had the disease and/or ovarian cancer, according to new research from The University of Texas MD Anderson Cancer Center.

The findings, published online in Cancer and updated since first presented at the 2009 Breast Cancer Symposium, could have an impact on how women at highest risk for the disease are counseled and even screened in the future, explained Jennifer Litton, M.D., assistant professor in MD Anderson's Department of Breast Medical Oncology.

"In our practice, we've noticed that women with a known deleterious BRCA gene mutation are being diagnosed earlier with the disease than their moms or aunts," said Litton, the study's first author. "With this study, we looked at women who had been both treated and had their BRCA testing at MD Anderson to determine if what we were seeing anecdotally was consistent scientifically, a phenomenon known as anticipation."

It's estimated that five to 10 percent of all breast cancers are associated with either the BRCA1 or 2 mutation, both of which are associated with an increased risk for breast and ovarian cancers. According to the American Cancer Society (ACS), women with BRCA1 or 2 have a 60 percent lifetime risk of developing breast cancer, compared to a 12 percent risk for women in the general population.

Given their greater risk, women with known BRCA mutations and/or whose mothers and/or aunts from either side of the family have the mutation are screened beginning at age 25. In 2007, as a complement to mammography, ACS guidelines added Magnetic Resonance Imaging (MRI) in the surveillance of these women at highest risk, as MRI is thought to catch smaller tumors even earlier. Consideration of prophylactic mastectomies is also a component of their surveillance, said Litton.

"Currently, BRCA positive women are c
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. States Get Creative in Raising Money for Breast Cancer Programs
2. Chemotherapy is as effective before breast cancer surgery as after
3. Computer-aided design used for breast tissue reconstruction
4. Flaxseed no help for hot flashes during breast cancer or menopause, study finds
5. Young women with early breast cancer have similar survival with breast conservation, mastectomy
6. For Young Breast Cancer Patients, Breast-Conserving Therapy Appears Effective
7. Annual Breast Exams, Mammograms Still Key to Detecting Breast Cancer
8. Going Straight to Chemo May Be Better for Certain Breast Cancers
9. Mothers postpartum oxycodone use: No safer for breastfed infants than codeine
10. Is Breast Reduction After Weight Loss Surgery Best?
11. Key function of mutation in hereditary breast and ovarian cancer gene discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... October 20, 2014 Allegheny General Hospital’s ... that enables physicians to repair a damaged mitral valve ... MitraClip system, developed by Abbott Vascular , ... progressive and life-threatening condition in which the heart’s mitral ... flow backward from the heart’s left ventricle into the ...
(Date:10/20/2014)... hc1.com today announced the launch ... that enables healthcare organizations of all sizes to ... relationship management (“CRM”) solution. , Designed from the ... the healthcare industry, the hc1 Healthcare Relationship Cloud™ ... by combining healthcare CRM, HIPAA-compliant collaboration, and real-time ...
(Date:10/20/2014)... AttorneyOne.com, a recognized authority on law, update ... FDA on Sit and Slim II . , ... or use Sit and Slim II because it contains ... as weight loss product on various websites and possibly in ... 2010 for safety reasons, can significantly increase blood pressure and/or ...
(Date:10/20/2014)... October 20, 2014 National Teen Driver Safety ... the American Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) ... encouraging parents of teen drivers to talk to their teens ... , Motor vehicle crashes are the leading cause of death ... involved in fatal crashes, and 859 (42%) of those teen ...
(Date:10/20/2014)... Houston plastic surgeon Dr. Christopher Patronella ... innovative True Form Tummy Tuck® method as ... at The University of Texas Medical Branch in ... medical student. Patronella, who is a founding partner of ... in Texas, The Aesthetic Center for Plastic Surgery ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2
... (NYSE:,NTY) (http://www.NBTY.com ), a leading global manufacturer and ... cast the,presentation by Harvey Kamil, President and Chief Financial ... in New York on Wednesday,September 17, 2008., The ... NBTY,s web site, (http://www.nbty.com ) on Wednesday, September 17, ...
... Calif., Sept. 11 Abaxis, Inc.,(Nasdaq: ABAX ), ... today that Clint Severson, CEO and,President, will present at ... 17, 2008 at 8:00 a.m. EDT, at the Omni ... Abaxis develops, manufactures and markets portable blood analysis,systems ...
... Kurian, MD, and her colleagues at the Stanford University ... identify women who might have dangerous genetic mutations that ... well for white women. But they seemed to be ... repeatedly surprised when Asian women who the models predicted ...
... Wolters Kluwer Health, a,division of Wolters Kluwer, ... for students, professionals, and institutions in medicine,nursing, ... announced,today the appointment of Scott Lubeck Vice ... Lubeck comes to Wolters Kluwer Health ...
... Sept. 11 Vasculitis,Foundation (VF), the leading organization ... all types of vasculitis, is taking,its advocacy and ... of its,first-ever webinar, Monday, September 22, 12:30 - ... easily accessible information about,vasculitis to the medical community ...
... newly-developed technology at the Delft University of Technology in the ... be a thing of the past. This is the message ... Institute Delft (RID) in an article in university journal ... hospitals are facing a shortage of radio isotopes which means ...
Cached Medicine News:Health News:NBTY to Web Cast Presentation at CL King Best Ideas Conference 2Health News:Risk of breast cancer mutations underestimated for Asian women, Stanford study shows 2Health News:Risk of breast cancer mutations underestimated for Asian women, Stanford study shows 3Health News:Wolters Kluwer Health Appoints Scott Lubeck Vice President, Technology of its Professional & Education Unit 2Health News:Vasculitis Foundation Integrates Education, Outreach and Technology in First-Ever Webinar on Potentially Life-Threatening Disease 2Health News:Delft University of Technology patent for manufacturing radio isotopes 2
(Date:10/20/2014)... N.Y. , Oct. 20, 2014 Pharmaceutic ... outsourcing facility in Albany, NY ... trials. The company meets and/or exceeds the FDA standards ... and 21 CFR Part 211. The ... the highest levels of quality assurance and quality control. ...
(Date:10/20/2014)... -- Norgine B.V. today announced that the ... preparation, NER1006, presented at the 79 th Annual ... Philadelphia, PA , has met its ... endpoint of cleansing success. The study demonstrated high quality ... in screening colonoscopy patients. [1] (Logo: ...
(Date:10/19/2014)... , October 20, 2014 Shire plc (LSE: ... , Interim Chief Financial Officer (CFO), has notified the Board of ... to pursue a new career opportunity as CFO of Severn Trent ... and the company will commence a search for a new CFO ... "James has helped build and lead a high-quality finance team ...
Breaking Medicine Technology:Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4
... Dec. 22, 2010 SCOLR Pharma, Inc., a Delaware corporation ... it notified the NYSE Amex Exchange (the "Exchange") of its ... Exchange Commission (the "Commission") to effect the voluntary withdrawal of ... to file the Form 25 with the Commission on or ...
... WPI ) today announced the U.S. Food and ... – the first and only low dose oral contraceptive to ... chewable form, with four 75 mg ferrous fumarate (iron) placebo ... proven effective in lowering the risk of pregnancy. ...
Cached Medicine Technology:SCOLR Pharma, Inc. Announces Intention to Voluntarily Delist From NYSE AMEX Exchange 2SCOLR Pharma, Inc. Announces Intention to Voluntarily Delist From NYSE AMEX Exchange 3SCOLR Pharma, Inc. Announces Intention to Voluntarily Delist From NYSE AMEX Exchange 4Watson Announces Novel Oral Contraceptive Approval 2Watson Announces Novel Oral Contraceptive Approval 3Watson Announces Novel Oral Contraceptive Approval 4
Marquette General Health System Reference Laboratory provides a full range of testing including, Chemistry, Hematology, Coagulation, Urinalysis, Microbiology, Cytology, Anatomic Pathology, Flow Cytom...
... The Johns Hopkins University Dermatology, ... Laboratory is a federally-(Clinical Laboratory Improvement ... that began operation in 1982. Its ... quality diagnostic allergy and immunology testing ...
... national reference laboratory and a laboratory ... an extensive test menu of highly ... clinical and anatomic pathology. Owned by ... clients include university teaching hospitals and ...
Sharp tipped scissors angled 135 from the shaft with a horizontal cutting action. For cutting in the plane parallel to the retina and cutting membranes adherent to the retinal surface (delamination)....
Medicine Products: