Navigation Links
Breast cancer metastasis increases after estrogen and progestin hormone therapies, MU study finds
Date:5/6/2010

COLUMBIA, Mo. After menopause, 6 to 10 million women take hormone therapies, which are often a combination of estrogen and progestin, to replace hormones lost from inactive ovaries. Progestin is a hormone that is used to counteract the potentially negative effects of estrogen therapy on the uterus. In studies sponsored by the National Institutes of Health, evidence has been found that estrogen and progestin in hormone therapies increase the risk of breast cancer in post-menopausal women. Now, a University of Missouri study has found that progestins can also increase the chance of the cancer metastasizing, or spreading to the lymph nodes.

"In our study, we found that progestins increase the number of blood vessels that are responsible for transporting existing cancer cells," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center. "The more the blood vessels increase, the higher the chance of cancer cell metastasizing. Progestins could even be more harmful to women who have functionally abnormal p53, a protein that acts as a tumor suppressor. In the absence of p53, progestins increase the release of a protein from tumor cells that allows formation of new blood vessels within tumors."

In the study, researchers compared the effects of several types of commonly used progestins on breast cancer tumors in an animal model. Researchers found that all types of progestin tested act in the same way and increased the risk of metastasis. Also, results showed that estrogen and progestin acted the same way whether taken together or separately. Although Hyder said that the study was independent of whether or not the ovaries were intact, it's still unclear whether progestins have the same effects in pre-menopausal women.

"Especially if there's a family history of breast cancer, it's advisable not to take progestins.
'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Broccoli May Help Battle Breast Cancer
2. Edgy, Sassy And Informative: New Website for Breast Cancer Survivors To Get Real About Their 'New Normal'
3. Whole body MRI is highly accurate in the early detection of breast cancer metastases
4. PMH cancer researchers link ovarian hormone to breast stem cells growth
5. Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research
6. Aggressive Action Urged When Evaluating Breast Lesions
7. Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy
8. Study evaluates importance of timeliness of care in breast cancer diagnosis and treatment
9. Smoking Ups Risk of Second Breast Cancer
10. Summer Brings Increased Demand For Breast and Body Enhancement
11. Largest Internet Supplier of Eternity Rings Pledges 10% of their Profits to the National Breast Cancer Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Jan Wooden Howse lost her husband and her son, ... God does no wrong. , It’s fitting, then, that her ... titled “God Does No Wrong.” It focuses on what happens ... , “My story has a positive message about channeling ... productive, something healing,” Howse said. , “God Does No Wrong” ...
(Date:5/29/2015)... 2015 Johnson & Johnson and ... Risperdal lawsuit ( http://www.risperdallawsuit2014.com/ ) settlement with a ... his use of the antipsychotic medication. According to ... the third bellwether trial to involve male breast ... in Pennsylvania’s Philadelphia Court of Common Pleas, where ...
(Date:5/29/2015)... May 29, 2015 A group of doctors ... joined the national effort to teach this “new math” to ... U.S. have been “sickened” by the recent implementation of Common ... or hate it, Common Core is now a reality in ... Parents are now seeking ways to improve common core ...
(Date:5/29/2015)... Intermountain Healthcare of Salt ... Stratus Video Interpreting for on-demand medical ... and timely care for patients with limited ... video remote interpreting (VRI) services will supplement ... quickly access qualified medical interpretation in nearly ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 The print ... with a circulation of approximately 250,000 and an estimated ... through a vast social media strategy, and across a ... explore the digital version of the campaign, click ... the print publication. Inside, the actress, model and producer ...
Breaking Medicine News(10 mins):Health News:Turning grief from a child’s passing into virtue 2Health News:Risperdal Lawsuit Selected as Pennsylvania’s Third Bellwether Gynecomastia Case Settles Hours Before Trial 2Health News:Risperdal Lawsuit Selected as Pennsylvania’s Third Bellwether Gynecomastia Case Settles Hours Before Trial 3Health News:Doctors Discover a Cure for the Common Core 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 4
... reported a study by the researchers of the Health Sciences ... women in their 40s leads to diagnosis of breast cancer ... more effective and less radical treatment options.// ,Sandra Buseman, ... nearly 25% of all breast cancer deaths occur in women ...
... Recent studies on birth control pills have been linking ... using these pills. However, a new study published by ... colleagues, has contradicted previous studies by stating that women ... gestodene show no increased risk for heart attack compared ...
... throbbing pain, sometimes accompanied by visual disturbances as ... been found to respond to a drug hitherto ... ,Norwegian researchers reported that drugs like candesartan cilexetil ... attacks. The Norwegian team decided to study Atacand ...
... French Scientist and member of the Raelian cult, Brigetter Boisselier, ... born yesterday through cloning, the first on record. In a ... society Clonaid said that the girl was born by caesarean ... the Raelians to achieve the first human birth by cloning ...
... Researchers according to their new study,observed that laughter is ... in the country in Mumbai in 1995 by Madan ... towns in the State. Laughter is believed to be ... man keep his body and mind active.// Laughter clubs ...
... AIDS may progress as a disease is the human ... that it confounds the already-weakened immune system's ability to ... determine how well a person// infected with HIV can ... from Harvard Medical School's Center for Blood Research, have ...
Cached Medicine News:Health News:Breast Cancer in younger women can be detected at an early stage by mammograms 2Health News:No heart attack risk for women taking birth control pills 2Health News:Drug used to treat hypertension effective in countering Migraines 2Health News:Laughter – best medicine to good healt 2Health News:Success of HIV may depend in its mutations 2
(Date:5/29/2015)... , May 29, 2015  Epic Sciences announced today ... data, from metastatic castrate resistant prostate cancer patients, ... Society for Clinical Oncology. This application expands the ... left behind™ platform to characterize circulating tumor ... late stage patients have heterogeneous clonal CTC populations ...
(Date:5/28/2015)... -- Eli Lilly and Company (NYSE: LLY ) announced today ... for up to $1.6 billion aggregate principal amount of certain ... who tendered, and did not validly withdraw, their notes on ... time, on May 27, 2015 (the early tender date), ... to receive the total consideration. The total consideration for each ...
(Date:5/28/2015)...  Maetrics ( http://maetrics.com ), a leading international consulting ... a successful conference, "The cost of non-compliance -- How new ... Zurich . Hosted ... Switzerland -based team, experts provided insights on ... to an exclusive local audience. The event was held ...
Breaking Medicine Technology:Genetic Analysis of Single Circulating Tumor Cells Shows High Intra-patient Heterogeneity 2Genetic Analysis of Single Circulating Tumor Cells Shows High Intra-patient Heterogeneity 3Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 2Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 3Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 4Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 5Maetrics Hosts Innovative Medical Cluster Event in Switzerland 2
... Calif., Aug. 29, 2011 Bioness Inc., today announced the ... the U.S. Food and Drug Administration (FDA) earlier this year, ... Drop System with a thigh cuff to activate even more ... control while walking. The L300 Plus ...
... NxStage® Medical, Inc. (Nasdaq: NXTM ), ... announced that former NxStage® System One™ patient Tederra ... successful kidney transplant. Coleman, 33, of Pompano Beach, ... of daily home hemodialysis with the NxStage System ...
Cached Medicine Technology:Bioness Inc Announces Availability of L300 Plus System 2Former NxStage System One User Celebrates One-Year Kidney Transplant Anniversary 2Former NxStage System One User Celebrates One-Year Kidney Transplant Anniversary 3Former NxStage System One User Celebrates One-Year Kidney Transplant Anniversary 4
The Onyx® 9500 worlds first self-contained digital fingertip pulse oximeter incorporates the electronics and the sensor into one unit....
The SportStat Pulse Oximeter shines red and infrared light through a finger and detects the fluctuating signals caused by blood flow. Pulse rate is determined from the signals received by a light det...
Ergonomically designed, the Invacare Printing Pulse Oximeter provides fast, reliable spot-check information and documentation of SpO2 and pulse rate. It is ideal for all patients from neonate to adul...
The FetalSAT™ System with DualSens Sensor displays continuous, real-time fetal pulse oximetry (FSpO2) and fetal pulse rate (FPR) values in one compact monitor....
Medicine Products: