Navigation Links
Breast cancer metastasis increases after estrogen and progestin hormone therapies, MU study finds
Date:5/6/2010

COLUMBIA, Mo. After menopause, 6 to 10 million women take hormone therapies, which are often a combination of estrogen and progestin, to replace hormones lost from inactive ovaries. Progestin is a hormone that is used to counteract the potentially negative effects of estrogen therapy on the uterus. In studies sponsored by the National Institutes of Health, evidence has been found that estrogen and progestin in hormone therapies increase the risk of breast cancer in post-menopausal women. Now, a University of Missouri study has found that progestins can also increase the chance of the cancer metastasizing, or spreading to the lymph nodes.

"In our study, we found that progestins increase the number of blood vessels that are responsible for transporting existing cancer cells," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center. "The more the blood vessels increase, the higher the chance of cancer cell metastasizing. Progestins could even be more harmful to women who have functionally abnormal p53, a protein that acts as a tumor suppressor. In the absence of p53, progestins increase the release of a protein from tumor cells that allows formation of new blood vessels within tumors."

In the study, researchers compared the effects of several types of commonly used progestins on breast cancer tumors in an animal model. Researchers found that all types of progestin tested act in the same way and increased the risk of metastasis. Also, results showed that estrogen and progestin acted the same way whether taken together or separately. Although Hyder said that the study was independent of whether or not the ovaries were intact, it's still unclear whether progestins have the same effects in pre-menopausal women.

"Especially if there's a family history of breast cancer, it's advisable not to take progestins. It's a difficult call that must be made on an individual basis by a physician," Hyder said. "The next step for this research is finding a type of progestin that does not cause tumor progression but still protects the uterus. Also, we're trying to see if it's possible to give patients something in addition to estrogen and progestin that can protect the breast."


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Broccoli May Help Battle Breast Cancer
2. Edgy, Sassy And Informative: New Website for Breast Cancer Survivors To Get Real About Their 'New Normal'
3. Whole body MRI is highly accurate in the early detection of breast cancer metastases
4. PMH cancer researchers link ovarian hormone to breast stem cells growth
5. Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research
6. Aggressive Action Urged When Evaluating Breast Lesions
7. Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy
8. Study evaluates importance of timeliness of care in breast cancer diagnosis and treatment
9. Smoking Ups Risk of Second Breast Cancer
10. Summer Brings Increased Demand For Breast and Body Enhancement
11. Largest Internet Supplier of Eternity Rings Pledges 10% of their Profits to the National Breast Cancer Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... pleased to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate ...
(Date:12/8/2016)... Plainsboro, NJ (PRWEB) , ... December 08, 2016 , ... ... patients, cancer centers and advocacy groups, has aligned with Upstage Lung Cancer in efforts ... In making the announcement, Michael J. Hennessy, Jr said, “CURE Media Group is honored ...
(Date:12/8/2016)... , ... December 08, 2016 , ... Premier Fitness Camp ... FIT , the ultimate weight loss and wellness program, at their world headquarters of ... to provide immediate and long-term results to anyone seeking weight loss, personal development, a ...
(Date:12/8/2016)... ... December 08, 2016 , ... Catalent Pharma ... drugs, biologics and consumer health products, today announced that it had joined the ... as a non-profit organization to unite pharmaceutical and healthcare companies that share a ...
(Date:12/8/2016)... ... December 08, 2016 , ... California Senate Bill (SB) ... per workers’ compensation claim in 2013 and 2014, according to CompScope™ Medical Benchmarks ... (WCRI) . , According to the study, medical payments per claim in California decreased ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Research and Markets has announced the addition of ... report to their offering. ... The report also analyses the market by the following Technology Types: Label-Free ... the US, Canada , Japan , ... Latin America , and Rest of World. Annual ...
(Date:12/9/2016)... aTyr Pharma, Inc. (Nasdaq: LIFE ), a ... to address severe, rare diseases, today announced that senior management will ... Success Healthcare Conference at the InterContinental Barclay Hotel in ... 4:20 p.m. ET. About aTyr Pharma ... aTyr Pharma is engaged ...
(Date:12/9/2016)... , Dec. 9, 2016  Forge Therapeutics, Inc. ... (Frankfurt Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) to ... for the treatment of bacterial infections including those ... recognized as an attractive antibacterial target for more ... of suitable chemical starting points has hampered its ...
Breaking Medicine Technology: