Navigation Links
Breast cancer is more aggressive in African-American women
Date:10/29/2007

New Haven, Conn.African American women are diagnosed with breast cancer at a younger age and have larger tumors and more lymph node involvement than Caucasian women, a Yale School of Medicine researcher reported today.

Speaking at the American Society for Therapeutic Radiology and Oncology meeting in Los Angeles, Meena Moran, M.D., assistant professor of therapeutic radiology and Yale Cancer Center member, said her results were based on 2,164 Caucasian women and 207 African American women followed over a 30-year periodthe largest most comprehensive study of its kind to date. All underwent lumpectomies in which the tumor, not the entire breast, was removed.

The incidence of breast cancer is actually lower in African American women compared to Caucasian women, yet their mortality rates are higher, Moran said. We were surprised. Previous reports did not show higher relapse rates in African American women after surgery to conserve breast tissue. This might be because we had so many African American patients and a longer follow-up period.

She said there are several possible biological risk factors that need to be explored more fully. African American women have a lower level of estrogen/progesterone receptors, which means existing anti-estrogen therapies are not effective on these tumors. African American women have a higher rate of triple negative tumors, which have been associated with a worse outcome in early stage breast cancer. They also have a higher rate of mutation in the p53 gene, which normally acts to suppress tumors.

In terms of outcomes after treatment, Moran said, African American patients were found to have a significantly higher rate of relapse in the breast and lymph nodes after breast conservation treatment compared to Caucasians. We did not, however, find any differences in the rate of cancer spreading to other locations such as the lung, bone, or liver, or in the overall survival in the two groups of patients.

Moran said she hoped that the study would increase awareness of the aggressive nature of breast cancer in African American women. She said this does not mean that African American women should not have lumpectomies. She emphasized that greater attention should be paid to ensure the tumor is completely removed and that follow up radiation therapy is adequate and includes the entire breast and lymph nodes.

We hope that patients and physicians will help reduce the gap in the disparities between the two populations by improving early detection/screening, better access to care and compliance with chemotherapy and radiation, Moran said. These patients can modify their lifestyles to decrease risk factors, such as obesity. There also is a need for African American patients to take part in large breast cancer studies to better understand the ethnicity based differences in breast cancer.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Breast cancer treatment to be determined by gene test
3. Ductal lavage may detect early breast cancer
4. Breast Feeding prevents obesity later on in life
5. Exclusive breast-feeding advised for six months in infants recommends World Health Organization
6. Breast milk is essential
7. Exercise to Prevent Early Breast Cancer
8. Cholesterol Drugs Prevent Breast Cancer
9. Breastfeeding not found to have an impact on weight of the child.
10. Smoking and Breast Cancer - A Deadly Combination
11. The Use Of MRI For Screening Of Breast Cancer Questioned
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... While it’s often important to take certain medications during the ... Texas, has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL ... it eliminates the need to turn on a light when taking medication during the ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
Breaking Medicine Technology: