Navigation Links
Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
Date:5/22/2012

therapy, long-term remission is uncommon and life expectancy is about three years. Currently, these patients have few therapeutic options. By adding an HSP90 inhibitor, Lin and Whitesell hope to hobble the resistant cancer cells, making them less likely to escape the effects of fulvestrant.

Lin likens a malignant tumor to a car on a highway in a high-speed chase. As the car hurtles down the road, police may erect a roadblock to stop it. In the case of ER+ breast cancer, that roadblock is hormonal therapy. Unfortunately, a tumor may mutate enough to find a detour around the roadblock and continue on its destructive course. Adding a heat shock protein inhibitor to the mix may thwart the cancer's ability to find an alternate route.

"Because of the way HSP90 inhibitors work, it's like throwing a bunch of roadblocks across a bunch of detours," says Lin, who will be running the clinical part of the trial. "So the idea is to try to block these alternative pathways that might allow the tumor to grow."

"Inhibiting HSP90 in tumors may not cause them to roll over and die," says Whitesell, who with support from Susan G. Komen for the Cure will be analyzing blood and tissue samples from trial participants. "But it may change the biology of the cancer to make it more susceptible to other things that we already know work against the cancer, like fulvestrant."

The trial's premise is based on years of work the Lindquist lab has conducted on heat shock proteins. That experience is invaluable, according to Sandro Santagata, a pathologist in the Lindquist lab who will also be examining patient tissue samples.

"The Lindquist lab has a great basic scientific understanding of the biology of the heat shock system," says Santagata. "That foundation will hopefully provide important insights to increase the likelihood of success for this trial and if it doesn't work, an understanding of why. That's always a tricky part. Figuring out the 'why' i
'/>"/>

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 2014 What: Rutgers Presbyterian Church, ... Side that embodies the inclusion and diversity of ... and the Ecological Crisis, a public lecture led ... Emerita of Old Testament at Louisville Presbyterian Seminary. ... that lends insight into current ecological problems, including ...
(Date:9/23/2014)... benefits of preventing a reduction in the rates ... today by the American College of Physicians (ACP). ... Medicaid Primary Care Pay Parity Program: Unless Congress ... Care Will Expire," explains why it is critical ... pediatricians (and their related subspecialists), family physicians, and ...
(Date:9/23/2014)... Singapore (PRWEB) September 23, 2014 ... aesthetic clinics in Singapore and Malaysia providing advanced ... revolutionary BB powder to its impressive skin care ... strengthen the skin’s defences against the evil forces ... a healthy glow simultaneously, this new addition is ...
(Date:9/23/2014)... TUESDAY, Sept. 23, 2014 (HealthDay News) -- The ... million in additional funding in scientific trials to ... and clinical studies. The supplemental monies were ... fields, including basic immunology, cardiovascular physiology, neural circuitry, ... Sept. 23. "This funding strategy demonstrates our ...
(Date:9/23/2014)... Karl Klose, professor of biology and a researcher in ... teamed up with researchers at Ruhr University in Bochum, ... Their findings were released this week in an article ... of Sciences . , Cholera is an acute infection ... contaminated with the bacterium Vibrio cholerae . An ...
Breaking Medicine News(10 mins):Health News:Inhabiting Eden: Christians, Scripture, and the Ecological Crisis – Public Lecture to Discuss Faith-Based Environmentalism 2Health News:Unless Congress acts, patients may soon lose access to primary care 2Health News:Unless Congress acts, patients may soon lose access to primary care 3Health News:The Sloane Clinic™ introduces a revolutionary BB powder to its impressive skin care repertoire 2Health News:The Sloane Clinic™ introduces a revolutionary BB powder to its impressive skin care repertoire 3Health News:The Sloane Clinic™ introduces a revolutionary BB powder to its impressive skin care repertoire 4Health News:NIH Adds $10M to Encourage Gender Balance in Clinical Trials 2Health News:UTSA microbiologists discover regulatory thermometer that controls cholera 2
... at the University of Cambridge claim to have identified four ... ,They made this breakthrough by using the new trawling ... simultaneously instead of one by one. ,They believe ... 12 to 15 years, in which the inherited risk of ...
... by a team of researchers led by Dr Peter Burney ... ,As part of the study, researchers analysed schoolchildren who were ... ,Researchers asked their parents about their kids fruit consumption ... study found that although there was no connection between apple ...
... has been reduced to begging for survival in Orissa after villagers ... can be passed on by social contact. ,And ... Sukanti (name changed), only 30 years of age, and her younger ... Cuttack district, 50 km from here. ,Life became hell ...
... more likely to later develop Alzheimer's disease than people ... study published in the May 29, 2007, issue of ... Neurology. ,The study, which is part of ... with an average age of 79. Blood tests determined ...
... public health problem in many developing countries, frequently ... survive. Often undiagnosed or untreated, syphilis is passed from ... in prenatal programs to prevent the spread of HIV. ... College and the Groupe Haitien d'Etude du Sarcome de ...
... change policy, ministers from Asia - including India's - met ... for talks on world crises. ,The two-day Asia-Europe ... division between European countries seeking deep cuts in world carbon-dioxide ... global warming. ASEM is held every two years. India, Pakistan ...
Cached Medicine News:Health News:Scientists Identify Four Genes That Raise the Risk of Breast Cancer 2Health News:Apple Juice may Help to Keep Childhood Asthma at Bay 2Health News:Rapid Syphilis Could Prevent Congenital Disease and Stillbirths in Haiti 2Health News:Rapid Syphilis Could Prevent Congenital Disease and Stillbirths in Haiti 3Health News:EU Pushes Asian Nations on Climate Change Goals 2
(Date:9/23/2014)... , Sept. 23, 2014 Cerevast Therapeutics ... today the outcome of the first interim analysis ... the Company,s proprietary Clotbust ER TM ... ischemic stroke. The independent Data Safety Monitoring Board ... planned. "Clearing the pre-specified futility threshold ...
(Date:9/23/2014)... therapy recently began in the Czech Republic for ... the United States draws to a close today ... days to live now looks forward to his first day of kindergarten. ... complained of a headache in June, it was the first ... 23, when he completes proton radiation therapy for a brain ...
(Date:9/23/2014)... Sept. 23, 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... the acquisition, development and commercialization of innovative therapeutics addressing ... market with a primary focus on China ... Shrotriya , MD, Chairman and Chief Executive Officer of ... appointment was made in connection with the recently announced ...
Breaking Medicine Technology:Cerevast Therapeutics Announces Outcome of First Interim Analysis of Phase 3 CLOTBUSTER Trial for the Treatment of Acute Ischemic Stroke 2Cerevast Therapeutics Announces Outcome of First Interim Analysis of Phase 3 CLOTBUSTER Trial for the Treatment of Acute Ischemic Stroke 35-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 25-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 35-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 4CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 2CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 3CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 4
... SAN DIEGO, May 7, 2012  Halozyme Therapeutics, Inc. (NASDAQ: ... the quarter ended March 31, 2012. (Logo:  ... milestone in the first quarter with the European regulatory ... Roche," said Gregory I. Frost, Ph.D., President and Chief ...
... May 7, 2012 The National Council on ... customized, online educational modules to promote safe use ... in America, acetaminophen, is found in more than ... relievers, fever reducers, and sleep aids as well ...
Cached Medicine Technology:Halozyme Reports First Quarter 2012 Financial Results 2Halozyme Reports First Quarter 2012 Financial Results 3Halozyme Reports First Quarter 2012 Financial Results 4Halozyme Reports First Quarter 2012 Financial Results 5Halozyme Reports First Quarter 2012 Financial Results 6Safe Use of Acetaminophen 2Safe Use of Acetaminophen 3Safe Use of Acetaminophen 4
... manufactures slides that are compatible with multichannel ... the number of pipetting steps required to ... on the slides. Ask Immuno Concepts for ... slides. These slide formats are noted with ...
... ANA uses a patented HEp-2 cell line ... the sensitivity to SS-A/Ro autoantibodies, without affecting ... studies have been published worldwide on the ... to SS-A/Ro autoantibodies when used in place ...
... and ENA assays can be used ... antinuclear antibodies, which are associated with ... Systemic lupus erythematosus (Lupus), Sjgren's syndrome, ... sclerosis, scleroderma, polymyositis, dermatomyositis, and Raynaud's ...
... assays can be used to screen ... which are associated with various systemic ... erythematosus (Lupus), Sjgren's syndrome, mixed connective ... polymyositis, dermatomyositis, and Raynaud's phenomenon. They ...
Medicine Products: