Navigation Links
Breast cancer and heart disease may have common roots
Date:12/20/2011

TORONTO, ON., Dec. 20, 2011Women who are at risk for breast cancer may also be at greater risk for heart disease, new research has found.

The majority of women with hereditary breast and ovarian cancer have a mutated form of the BRCA1 or BRCA2 genes, which normally suppress the growth of breast and ovarian tumours.

Dr. Subodh Verma, a cardiac surgeon at St. Michael's Hospital, said his research team was surprised to discover the genes also regulate heart function.

Following a heart attack, mice with the mutated BRCA1 gene had a three-to-five times higher rate of death. This was largely due to the development of profound heart failure, possibly because their heart attacks were twice as severe as those in mice who did not have the mutated gene.

A similar two-fold increase in heart failure was observed when mice with a mutated BRCA1 or BRAC2 gene were treated with doxorubicin, one of the most common chemotherapy drugs for patients with breast cancer. In addition to studies in mice, the authors also verified this observation in human tissues.

The researchers believe that the mutated BRCA1/2 prevents DNA repair in muscle cells that is essential to recovery after a heart attack.

Their findings were published in the journals Nature Communications and Journal of Biological Chemistry.

"Our findings suggest that individuals who are at risk of breast cancer may also be at a previously unrecognized risk of heart disease," Dr. Verma said. "More importantly, we now understand that breast cancer and heart disease -- the two leading causes of death for Canadian women have a common biological basis, a common soil."

Dr. Verma emphasized that these findings may have important implications for patients. Knowing that the BRCA1/2 gene is essential to DNA repair may lead to future treatments for anyone with heart disease, a leading cause of death worldwide. Women who carry this mutated gene now know they may also be
'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... Keeping mold top of mind is important ... quite common. Mold can grow anywhere - on carpet, clothing, food, paper, and even ... moisture and water in the home is key to preventing mold growth, which if ...
(Date:9/4/2015)... ... September 04, 2015 , ... Bio-Logic Aqua® Research, a ... announced its only mission and research focus: Water Life Science®. In the current ... water evaporation is becoming dangerously accelerated. As a result of the global fresh ...
(Date:9/4/2015)... New York, NY (PRWEB) , ... September 04, 2015 , ... ... 400 meters qualifying heat, and followed up with victory in the men’s 400 meters ... Caribbean (NACAC) Senior Track and Field Championships in San Jose, Costa Rica in August ...
(Date:9/4/2015)... ... 04, 2015 , ... EMED Jamaica Global Ltd. (EMED), Jamaica’s ... entered into a multi-year agreement with Health City Cayman Islands. , ( http://www.healthcitycaymanislands.com ... American healthcare, Jamaican healthcare and Health City Cayman Islands to deliver high-quality, affordable ...
(Date:9/3/2015)... ... , ... TransPack Toon gives users a set of 90 cartoon transitions for ... in 30 different styles. Presets range from snow, underwater, forest, futuristic, city and many ... features 90 cartoon transitions from 30 unique styles. Editors can choose between line ...
Breaking Medicine News(10 mins):Health News:September is Mold Awareness Month 2Health News:September is Mold Awareness Month 3Health News:September is Mold Awareness Month 4Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 2Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 3Health News:Lalonde Gordon’s Recipe Brings Home the Gold 2Health News:Lalonde Gordon’s Recipe Brings Home the Gold 3Health News:EMED Agreement with Health City Cayman Islands Provides for Up to 80% Savings for Patients in Need of Medical Procedures 2Health News:EMED Agreement with Health City Cayman Islands Provides for Up to 80% Savings for Patients in Need of Medical Procedures 3Health News:EMED Agreement with Health City Cayman Islands Provides for Up to 80% Savings for Patients in Need of Medical Procedures 4Health News:EMED Agreement with Health City Cayman Islands Provides for Up to 80% Savings for Patients in Need of Medical Procedures 5Health News:EMED Agreement with Health City Cayman Islands Provides for Up to 80% Savings for Patients in Need of Medical Procedures 6Health News:Pixel Film Studios Releases TransPack Toon, a New FCPX Transition 2
... Shelves for Father,s Day , , NEW YORK, June 8 ... pain may lie in a $59.99 biomechanically-engineered foam and rubber flip-flop ... for the sixty million adults who reported persistent back pain last ... be a medical breakthrough is now available in the Dass, a ...
... , BALTIMORE, June 8 Metastorm, a leading provider ... and Enterprise Architecture (EA) software for aligning strategy with ... customer Wyeth Pharmaceuticals as one of this year,s CIO ... Wyeth is one of the world,s largest pharmaceutical and ...
... Factor Driving the Market Decline Will be Singulair,s Loss ... Decision Resources , , WALTHAM, Mass., June 8 ... and advisory firms for pharmaceutical and healthcare issues, finds ... and cost consciousness will reduce the asthma drug market ...
... Cedars-Sinai Outpatient Cancer Center Appointed COO , , ... today announced the appointment of Paul R. O,Dea to ... formerly Vice President, Aptium Oncology and Executive Director, Cedars-Sinai ... hospital-based cancer centers. The appointment was effective June 1, ...
... LOMBARD, Ill., June 8 A major session at the ... Conference will focus on how supply chains are helping to ... will be held September 20-23 in Chicago, Illinois. , ... improving delivery of drugs, vaccines, and other remedies to needy ...
... More Efficient Operation for Gateway Healthcare , , ... announced today that it is addressing the ... with the unique, next generation voice product, Cox ... moved its telecommunications services from a competitive provider to ...
Cached Medicine News:Health News:One of Women's Best Kept Secrets is Now Available in the Men's Department 2Health News:Metastorm Customer, Wyeth Pharmaceuticals, Wins CIO 100 Award for BPM Project 2Health News:Generic Erosion, Increased Competition and Cost Consciousness Will Reduce Overall Asthma Drug Market by $1.8 Billion from 2008 to 2018 2Health News:Aptium Oncology Names New Chief Operating Officer 2Health News:Cox Business Addresses Complex Voice Needs of Health Care Organization 2Health News:Cox Business Addresses Complex Voice Needs of Health Care Organization 3Health News:Cox Business Addresses Complex Voice Needs of Health Care Organization 4
(Date:9/4/2015)... PUNE, India , September 4, 2015 /PRNewswire/ ... Industry, 2015 Market Research Report is a professional ... the global Surgical Gown industry with a focus ... will take 2-3 working days once an order ... gown market spread across 150 pages, analyzing and ...
(Date:9/4/2015)... 4, 2015 According to a ... Plateletpheresis, Erythrocytapheresis, Leukapheresis, and Photopheresis) by Procedure (Therapeutic Apheresis, ... - Global Forecast to 2020", published by MarketsandMarkets, the ... Billion by 2020, growing at a CAGR of 11.2% ... Browse 139 Tables and 45 F ...
(Date:9/4/2015)...  Cumberland Pharmaceuticals (CPIX), today announced that A.J. Kazimi ... on September 10, 2015. DATE: Thursday, September ... http://tinyurl.com/sep10pre This will be a ... ask the company questions in real-time - both in ... trade booth." If attendees are not able to join ...
Breaking Medicine Technology:Surgical Gown Market 2020 Forecasts With a Focus on China 2Surgical Gown Market 2020 Forecasts With a Focus on China 3Surgical Gown Market 2020 Forecasts With a Focus on China 4Apheresis Market Worth 2.5 Billion USD by 2020 2Apheresis Market Worth 2.5 Billion USD by 2020 3Apheresis Market Worth 2.5 Billion USD by 2020 4Apheresis Market Worth 2.5 Billion USD by 2020 5Cumberland Pharmaceuticals to Webcast, Live, at VirtualInvestorConferences.com September 10 2
... - Phase 2 trial expected to begin in late ... June 4 Nuvelo, Inc.,(Nasdaq: NUVO ) today ... a,single-center, Phase 1b trial to determine the safety, tolerability ... direct,thrombin-inhibiting aptamer, in approximately 30 healthy male volunteers., ...
... at American Society of Clinical Oncology meeting indicate ... compared to historical data., PRINCETON, N.J., June ... CPX-1 Phase 2 clinical trial in patients,with advanced ... and floxuridine, based on the company,s proprietary,CombiPlex(TM) technology. ...
Cached Medicine Technology:Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172 2Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172 3Celator(R) Pharmaceuticals Announces Positive Phase 2 Results for CPX-1 in Treatment of Colorectal Cancer 2Celator(R) Pharmaceuticals Announces Positive Phase 2 Results for CPX-1 in Treatment of Colorectal Cancer 3
... a unique and versatile posterior spinal implant ... as a translational implant in correction of ... for bone or metallic implants, cables have ... configurations. Songer Cables offer advantages in strength, ...
Demineralized bone matrix dispensed in a jar. Fibers will be free of foreign matter. Glycerol 70-88% by weight. Calcium content less than 8%....
Demineralized bone matrix dispensed in a syringe. DBM will be free of foreign matter. Demineralized bone matrix particle size 125 to 850 . Glycerol 70-88% by weight. Calcium content less than 8%....
... matrix and conductive cancellous chips. ... be free of foreign matter. ... is 125 to 1000 . ... 1 - 8 mm. 5:3 ...
Medicine Products: