Navigation Links
Breast cancer: Reducing the risk of unnecessary chemo
Date:11/8/2010

This release is available in French.

A fundamental principle of medicine is: "first, do no harm." However, for doctors who treat breast cancer, this is easier said than done. Every year, almost 22,000 Canadian women are diagnosed with breast cancer their treatment usually involves surgery to remove a tumour and then chemotherapy to reduce the risk of cancer returning. But studies show that for most patients with early stage breast cancer, chemotherapy following surgery is totally unnecessary and therefore does more harm than good.

Identifying whether a patient's cancer is at low or high risk of recurring would help doctors reduce unnecessary treatments for low risk patients. This could have a huge impact on a patient's quality of life and also significantly reduce the cost of health care.

Did you know?

Chemotherapy can be devastating both physically and emotionally. Side effects of breast cancer chemotherapy range from nausea, vomiting and hair loss to mouth sores, menopause, infertility, numbness and aching of the joints, hands and feet.

Currently, most doctors assess a patient's prognosis using their age and "tumour grade," but this approach doesn't work very well. Now, NRC researchers have developed a tool to determine which breast cancer patients have little risk of their disease recurring. The tool an algorithm that identifies "gene expression signatures" or biomarkers that can predict low risk tumours with 87-100 percent accuracy in different groups of patients has the potential to virtually eliminate unnecessary chemotherapy.

To conduct their study, which appeared in a recent issue of Nature Communications, Dr. Edwin Wang and his colleagues at the NRC Biotechnology Research Institute in Montreal (NRC-BRI) used published data on gene expression profiles from more than 1000 breast cancer samples. "Every tumour has a gene expression profile, which indicates how the patient's genes have changed," he explains. "We combined this data with information on the patient's outcome such as whether the original tumour spread and how long the person survived to develop our algorithm."

The NRC team now hopes to see its algorithm applied in a clinical setting. "We have a provisional patent on the intellectual property and we would like to get a Canadian company to license it and turn it into a kit format," says Dr. Maureen O'Connor of NRC-BRI, who co-authored the study. "We've had interest expressed from more than one company so far."

Dr. O'Connor adds that the NRC algorithm could be adapted to other types of cancer where over-treatment is common, such as prostate cancer. "Prostate cancer in particular is usually not an aggressive disease, but the treatment can be extreme," she says. "We would like to develop a test that can predict with 99 percent accuracy whether a patient's cancer is not aggressive, so they can make the best decision about whether to proceed with treatment right away."

In future, the algorithm may also help pave the way toward personalized therapy for cancer patients. "On average, every cancer patient has 14-16 mutated genes," says Dr. Wang. "Based on their unique genetic signature, we hope to figure out which mutations to target to block the cancer process in each patient."


'/>"/>

Contact: NRC Media Relations
media@nrc-cnrc.gc.ca
613-991-1431
National Research Council of Canada
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
Breaking Medicine Technology: