Navigation Links
Breast Radiation After Lumpectomy Saves Lives: Study

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Oct. 19 (HealthDay News) -- Women with breast cancer who undergo radiation after a lumpectomy have significantly fewer recurrences and, consequently, greater odds of survival than women who forgo radiation, new research says.

The study also noted no long-term adverse effects from radiation after this breast-conserving surgery, as deaths from any cause were also reduced substantially.

"For the first time, this showed this important linkage between using radiation to avoid local recurrence and improving long-term survival," said Dr. Jay Harris, chairman of radiation oncology at Dana-Farber Cancer Institute and Brigham & Women's Hospital in Boston. "Up until 2005, the prevailing attitude in the U.S. was that radiation did not have an impact on improving long-term survival and was strictly to reduce local recurrence."

Giving radiotherapy after breast-conserving treatment is already common practice, said Dr. Shelly Hayes, a radiation oncologist with Fox Chase Cancer Center in Philadelphia. The point is to destroy any stray cells in the affected breast.

The findings echo the results of a landmark 2005 paper that involved fewer women and shorter follow-up. They should help erase any lingering doubts among skeptics, experts said.

"It is going to be very helpful to see updated results with lots more patients, lots more follow-up and this is very substantial improvement in long-term outcome," Harris said.

Here, the authors assessed data on almost 11,000 women in 17 randomized trials that compared radiation with no radiation after lumpectomy.

The authors took the unusual step of including both published and unpublished trials, making "the data very reliable," said Harris.

Overall, irradiating the affected breast halved recurrence rates and cut the mortality rate by one-sixth, the researchers said.

After 10 years, 19 percent of women who had undergone radiation had had a recurrence compared with almost twice as many -- 35 percent -- in the non-radiation group.

And 15 years after diagnosis, 25 percent of women with radiation were alive, vs. 21 percent in the control group. At that time, the absolute risk reduction in all-cause mortality was 3 percent, the study found.

The numbers varied according to age, grade of tumor, estrogen-receptor status, whether the patient had taken the estrogen-suppressing drug tamoxifen and how extensive the surgery had been.

"The magnitude of the benefit got smaller with more favorable factors, but there were benefits in every subgroup, which translated into benefit in terms of recurrence risk, which translated into overall survival," Hayes said.

"Across the board, no matter what those features were, women benefited from radiation," Hayes said.

For some time, doctors have wondered whether radiation was really necessary for all women, said study co-author Sarah Darby, professor of medical statistics at the University of Oxford in England.

"These findings will enable both doctors and patients to have a better idea of the benefit that is likely to be gained from radiotherapy on a patient-by-patient basis," she said.

More information

The U.S. National Cancer Institute has more on breast cancer treatments.

SOURCES: Sarah Darby, Ph.D., professor, medical statistics, University of Oxford, England; Shelly Hayes, M.D., radiation oncologist, Fox Chase Cancer Center, Philadelphia; Jay R. Harris, M.D., professor and chairman, radiation oncology, Dana-Farber Cancer Institute and Brigham & Women's Hospital, Boston; Oct. 20, 2011, The Lancet, online

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
Related Image:
Breast Radiation After Lumpectomy Saves Lives: Study
(Date:10/9/2015)... ... October 09, 2015 , ... The American Osteopathic ... for Graduate Medical Education J. Michael Finley, DO, as the recipient of the ... for his impact on graduate medical education opportunities for osteopathic residents, and his ...
(Date:10/9/2015)... ... October 09, 2015 , ... With the FCPX LUT Vibrance pack from Pixel ... LUT is a Lookup Table that contains a mathematical formula for modifying an image. ... This pack comes with 60 vibrant CUBE LUT files. , Inspired by ...
(Date:10/9/2015)... ... ... Smoke alarms can save lives. In fact, according to the National Fire ... home fires in half. As part of Fire Prevention Week, Amica Insurance ... , Half of home fire deaths result from fires reported between 11 p.m. and ...
(Date:10/9/2015)... ... October 09, 2015 , ... Head Over Heels Athletic Arts gymnast, ... camp at the Karolyi Ranch in Huntsville, Texas on October 17-21. , "It's ... girls team head coach and executive director, said. “It's a stepping stone into the ...
(Date:10/9/2015)... , ... October 09, 2015 , ... The Asthma and ... US Centers for Disease Control and Prevention (CDC) to improve the knowledge and skills ... AAFA has been awarded a project by the CDC and allows AAFA to continue ...
Breaking Medicine News(10 mins):
... Kenya in the last week after an outbreak of Rift ... spokesman said on Thursday//. ,The contagious disease, which ... mid-December, has now spread to the east African country's central, ... 108 new human infections since last week. ,The ...
... Following on the news of the drop in cancer ... Society is launching the Great American Health Challenge// to ... their cancer risk. ,Many Americans are concerned ... 50 percent of cancer deaths could be prevented through ...
... Child Study Center has received a $3.5 million National ... an ongoing, multidisciplinary research program// on autism and related ... focuses on developmental aspects and outcomes for affected patients. ... manifestations of autism in infants at risk for the ...
... to some of today’s health issues, 100 percent fruit ... to certain diseases – concludes// a study by European ... to reduce risk compared to their whole fruit/vegetable counterparts ... the literature review. The researchers analyzed a variety of ...
... out that consuming the right type of fat may actually ... consume lesser quantities// of unsaturated fat and very little omega-3. ... age group of four was undertaken by scientists at Goteborg ... ,This study revealed that 23% of the children ...
... Japan came in for a lot of criticism this ... of describing women//. ,The minister was airing his views ... last Saturday, when the gaffe occurred. ,Quoting the minister: ... Because the number of birth-giving machines and devices is fixed, all ...
Cached Medicine News:
(Date:10/9/2015)... Calif. , Oct. 9, 2015 AcelRx Pharmaceuticals, ... will be made at the annual European Society of Emergency ... to October 14 th , 2015 at the Lingotto Congress ... EuSEM is the largest meeting of emergency medicine practitioners in ... countries represented. Data from the previously announced phase ...
(Date:10/9/2015)... 2015 Ansun BioPharma announced a presentation at ... ) regarding the compassionate use of DAS181 under an ... who was co-infected with influenza and parainfluenza (Abstract # ... O 2 requirement was reduced and the patient,s ... go off the respirator on day 5. Between day ...
(Date:10/9/2015)... -- Der " JCA-Mauvernay Award   2015 ... und Dr.   Junko Takita    --> Der ... geht an Dr.   Yutaka Kondo und Dr.   ... JCA-Mauvernay Award   2015 " geht an Dr. ...    ™ , das weltweit tätige Schweizer Biopharmazieunternehmen, wird am ...
Breaking Medicine Technology:
... The Detroit Medical Center (DMC) Cardiovascular Institute (CVI) ... to successfully open a patient,s blocked artery with a ... drill" to painlessly remove the plaque buildup which causes ... – conducted Wednesday by CVI Director of Endovascular Medicine ...
... HistoRx, the leader in quantitative immunohistochemistry, advances ... recent issuance of US patents covering key features ... results.  The U.S. Patent and Trademark Office has ... for standardization of digital microscopy instruments, methods required ...
Cached Medicine Technology:
Medtronic neurosurgery external drainage and monitoring (EDM) products meet a variety of needs for CSF drainage and monitoring....
... CODMAN EDS 3 CSF External Drainage System was ... and physicians. The clinicians who work every day ... CODMAN EDS 3: ease-of-use in an integrated pole ... valve, accurate hydrostatic leveling from a unique laser ...
Monitorr ICP external CSF drainage and monitoring system with patient line one way valve....
... Specifically designed for neuro and skull ... craniotomies, cranioplasties, craniofacial surgery, pediatric neurosurgery, ... orbital, and skull base regions, neuro ... instruments and implants in one compact ...
Medicine Products: