Navigation Links
Breast-Feeding Protected Mice From Asthma
Date:1/28/2008

Mothers conferred immunity to allergen; not known if findings apply to humans

MONDAY, Jan. 28 (HealthDay News) -- Breast-feeding helped protect baby mice from developing allergic asthma, a new study found.

The mice that were breast-fed by mothers that had been exposed to an allergen "inherited" the allergen and developed tolerance to it.

But once again, a central question is whether such an animal study can be extrapolated to humans.

"You hate to translate data on mice to data on humans," said Dr. Jennifer Wu, an obstetrician/gynecologist at Lenox Hill Hospital in New York City. "I wouldn't necessarily apply this to humans, especially because it's mice and not primates."

The findings were published online Jan. 27 in the journal Nature Medicine.

The incidence of allergic diseases such as asthma, food allergies and various skin conditions has soared during the past few decades. In children 4 years of age and younger, the incidence of asthma has risen 160 percent, while the incidence of atopic dermatitis, which includes eczema, has almost tripled. The incidence of peanut allergy has doubled just during the past decade, according to the American Academy of Pediatrics.

Although genetic factors clearly play a role in the trends, researchers have intensified their efforts to find environmental contributors. And, in fact, exposure to allergens in the environment during infancy reduces the risk of developing asthma.

It's been unclear, however, if breast-feeding has an impact on the development of allergic disease.

Earlier this month, the American Academy of Pediatrics (AAP) issued a report concluding that atopic disease, which includes eczema, asthma and food allergies, may be delayed or prevented in high-risk infants if they're exclusively breast-fed for at least four months or fed infant formula without cow milk protein.

"The article from AAP actually found conflicting data on asthma and breast-feeding," Wu said. "Breast-feeding did decrease wheezing in infants but didn't seem to decrease overall asthma."

For the new study, French researchers exposed lactating mice to an airborne allergen, ovalbumin, which is the main protein found in egg whites. Ovalbumin was transferred from the mother to the baby via breast milk and conferred immunological tolerance to the allergen.

The baby mice exposed to ovalbumin showed decreased airway "hyper-reactivity" and decreased mucus in the airways, among other benefits.

"No other experimental study has investigated whether exposure of lactating mice to an airborne allergen would impact asthma development in progeny. The allergen exposure was only restricted to the lactation phase starting one day after delivery to three weeks (weaning time)," said study senior author Valerie Julia, a permanent researcher with the National Institute of Health and Medical Research, University of Nice-Sophia-Antipolis in Valbonne.

"We found that airborne antigens are efficiently transferred from the mother to the neonate through milk. We believe that the presence of the allergen in milk together with the immunosuppressive molecule called TGF-beta "instructs" the immune system of the neonate not to over-react against the allergen," Julia added.

Although more studies need to be done to confirm the potential effect in humans, as Wu pointed out, "there are other huge benefits of breast-feeding in terms of nutrition and emotional bonding."

More information

The American Academy of Pediatrics has more on breast-feeding your infant.



SOURCES: Jennifer Wu, M.D., obstetrician/gynecologist, Lenox Hill Hospital, New York City; Valerie Julia, Ph.D., permanent researcher, National Institute of Health and Medical Research, University of Nice-Sophia-Antipolis, Valbonne, France; Jan. 27, 2008, Nature Medicine, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Breast-Feeding Seems to Protect Against Some Allergies
2. Breast-Feeding Cuts Food Allergy Risk
3. Breast-Feeding Confers Long-Term Heart Benefits
4. Successful Breast-Feeding
5. Breast-Feeding Doesnt Contribute to Cavities
6. New study shows worlds protected areas threatened by climate change
7. Cervical cancer screening: Too many are left unprotected
8. Asthma Foundation Expands Certification Program to be Friendly to Millions More
9. Investigating causes of asthma attacks: New sensor system monitors environmental exposure
10. Mediterranean Diet for Mom Fends Off Asthma, Allergies in Kids
11. Discovery opens door to personalized asthma therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Beleza ... Army body fat composition regulations. This is the first time that Coolsculpting is ... screened at least every six months to ensure they meet the prescribed body-fat standard, ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
(Date:5/26/2016)... ... ... There are many ways to cook a hot dog, but new research ... their dogs straight off the grill. Of the 90 percent of Americans who say ... a hot dog, far outpacing other cooking methods such as steaming (12 percent), microwaving ...
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, ... members and suppliers for its inaugural Member Conference at the Paris Hotel in ... elevating the operational health of America’s healthcare providers. , The conference was highlighted ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... On Memorial ... and women who lost their lives in military battle for the country. The ... in 2015 to provide more programs that empower independence for disabled military veterans, as ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... PUNE, India , May 25, 2016 ... "Medical Animation Market by Type (3D, 2D, 4D), by ... Patient Education), by End User (Medical Device Manufacturers, Hospitals/ ... report studies the global Medical Animation Market for the ... expected to reach USD 301.3 Million by 2021 from ...
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... SPRINGS, Florida , May 25, 2016 ... Business Conference & Expo earlier this month, the numbers ... As revenues continue to climb into the billions, more ... the newly released 4th Edition State of Legal Marijuana ... Frontier, a cannabis-focused data-analysis firm, much of the increase ...
Breaking Medicine Technology: