Navigation Links
Breast Cancer's Spread Now Better Understood
Date:12/6/2009

Findings offer hope for future treatments targeting growth factor, researchers say

SUNDAY, Dec. 6 (HealthDay News) -- The spread of breast cancer cells from the main tumor to other parts of the body is controlled by a growth factor known as TGFb, which may prove a promising target for new drugs to prevent metastatic breast cancer, British researchers say.

Previous studies have shown that TGFb (transforming growth factor beta) regulates normal cell growth and movement. In this new study, a team from Cancer Research UK used an advanced microscopy and analysis technique to document the movement of cancer cells from primary breast tumor sites in mice.

The researchers found that single breast cancer cells broke away from the main tumor and entered the blood system when TGFb turned on messenger genes in the cancer cells and then turned them off.

When TGFb was inactive, clumps (but not single cells) of breast cancer cells broke away from the main tumor. Because these clumps can spread only through the lymphatic system, not through the blood, the spread of cancer was local, the study authors explained.

"The results helped us to find the set of genes that are behind the spread of breast cancer -- and that the genes need to be first turned on and then off in order for single cancer cells to be able to 'relocate,'" study author Erik Sahai said in a news release from Cancer Research UK.

He noted that in "a medium-sized tumor there could be a billion cells -- and only a small proportion might break away and spread. So it is like trying to find -- and understand -- a moving needle in a very big haystack."

The study, published in the October issue of the journal Nature Cell Biology, is scheduled to be presented Sunday at the annual meeting of the American Society for Cell Biology, held Dec. 5 to 9 in San Diego.

More information

The U.S. National Cancer Institute has
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. MRI finds breast cancer before it becomes dangerous
3. Pathway links inflammation, angiogenesis and breast cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Breast cancer prevention practices vary across Canada
6. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
7. Acrylamide Wont Raise Breast Cancer Risk
8. New link between estrogen and breast cancer
9. Hypnosis Eases Pain of Breast Cancer Surgery
10. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
11. Longaberger Expands Horizon of Hope Campaign to Build Support for American Cancer Societys Breast Cancer Initiatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... (PRWEB) July 31, 2014 Etymotic ... announced a new sponsorship of the DrumLine Battle® ... are Etymotic’s hearing protection products ETY•Plugs® and Music•PRO® ... against the harmful effects of high-level sound. Etymotic ... sponsorship at the Drum Corps International Championships on ...
(Date:7/31/2014)... black women put concerns about their hair above their ... the U.S. Centers for Disease Control and Prevention that ... States are overweight or obese. Yet some of them ... their hair restyled or restraightened, the University of Colorado ... also noted a shift toward more "low-maintenance" hairstyles, which ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Rich Dad® ... charity yard sale to benefit Habitat for Humanity. The yard ... was raised with 100% of the proceeds donated to Habitat ... items not sold at the event were donated to the ... Road, North Fort Myers, Florida 33903. , Of the ...
(Date:7/31/2014)... aimed to diagnose pediatric patients with suspected appendicitis ... without affecting diagnostic accuracy, Mayo Clinic Children,s Center ... in the journal Surgery . , Acute ... abdominal pain in children. Appendicitis occurs when the ... scans are often used to diagnose acute appendicitis ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Insight Accelerator ... a Series A round of investment for $4.6 million ... device for collecting vital signs. The company joined ... technology to fruition with the help of Insight development ... our reason for launching the Accelerator,” says Steve McPhilliamy, ...
Breaking Medicine News(10 mins):Health News:Etymotic Research Becomes The Official Hearing Protection Sponsor Of DrumLine Battle 2Health News:Hairdo Trumps Exercise for Many Black Women, Study Finds 2Health News:Rich Dad Education Charity Yard Sale to Benefit Habitat for Humanity of Lee and Hendry Counties a Success 2Health News:Insight Accelerator Labs Advances Member Toward Commercialization 2Health News:Insight Accelerator Labs Advances Member Toward Commercialization 3
... rats finds that even one injection leads to dependent ... naturally occurring protein plays a role in the disrupted ... with drug and alcohol dependence, says a new study. ... changes in association with drug abuse, it could potentially ...
... May 28 (HealthDay News) --Should it worry you that there ... , Not especially, when you consider that there are 44 ... , This information comes to you from scientists at the ... same techniques that enabled them to map the human genetic ...
... Controlling Weight before PregnancyWHITE PLAINS, N.Y., May 28 ... right amount during pregnancy is critical to giving a ... Dimes said today in response to new guidelines from ... issued new guidelines for the amount of weight a ...
... Logistics (NGL), a premier provider of mission critical transportation, service/spare parts ... network of forward stocking locations (FSL,s). , ... Broomfield, ... provider of mission critical transportation, service/spare parts logistics , and ...
... Perot Systems, RCS advantages of increased cash flows and ... providersPLANO, Texas, May 28 Amerinet, a leading national ... PER ) ( www.perotsystems.com ) ... Systems revenue cycle solutions available to Amerinet,s acute and ...
... Patent Covers High-throughput, Anchorage-independent Assay for Screening Compounds ... Falcon Genomics, Inc. announced today that it ... covering the Company,s Cancer BioChip System (CBCS) for ... in a high-throughput in vitro setting ...
Cached Medicine News:Health News:Study Finds Multitude of Bacteria on Human Skin 2Health News:Study Finds Multitude of Bacteria on Human Skin 3Health News:New Guidelines to Fight Obesity in Pregnancy Issued 2Health News:New Guidelines to Fight Obesity in Pregnancy Issued 3Health News:NGL Expands Global Network to Service Parts Logistics Customers 2Health News:NGL Expands Global Network to Service Parts Logistics Customers 3Health News:Perot Systems to Supply Revenue Cycle Solutions to Amerinet Members Nationwide 2Health News:Perot Systems to Supply Revenue Cycle Solutions to Amerinet Members Nationwide 3Health News:Falcon Genomics Awarded Patent for Innovative Cancer Test 2
(Date:7/31/2014)... -- Tandem Diabetes Care®, Inc. (NASDAQ: TNDM ), ... Pump, today reported its financial results for the quarter ended ... quarter of 2014 to the same period of 2013: ... million , t:slim Pump shipments grew 64 percent to ... months ended June 30, 2014 to the same period of ...
(Date:7/31/2014)... , July 31, 2014  Cepheid (NASDAQ: CPHD ... the following conferences, and invited investors to participate via webcast. ... New York, NY Wednesday, August 13, ... Health Care Conference, New York, NY ... Accessing Live Webcasts To access the live webcasts ...
(Date:7/31/2014)... , July 31, 2014   Auxilium Pharmaceuticals , ... specialty biopharmaceutical company, today announced that the Company will ... Thursday, August 7, 2014 before the opening of the ... conference call that day at 8:30 a.m. ET to ... 2014. The presentation slides to be used during the ...
Breaking Medicine Technology:Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 3Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 4Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 5Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 6Cepheid to Webcast Upcoming Financial Presentations 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3
... III Study Provides Further Evidence of,the Significant ... Treatment,of Rheumatoid Arthritis, BASEL, Switzerland, June 6, ... multinational phase III Actemra,(tocilizumab) study, successfully reached ... proportion of patients treated with Actemra,in combination ...
... Topical Therapy Reduces TNF-alpha Production Through Inhibition,of ... 2007 /PRNewswire/ -- Anacor,Pharmaceuticals, a privately held ... placebo-controlled Phase 1 trial of,AN2728, a first-in-class ... psoriasis. The trial showed AN2728 to be,well-tolerated, ...
Cached Medicine Technology:New Data Confirms Significant Improvement of Disease Signs and,Symptoms in Patients with Rheumatoid Arthritis 2New Data Confirms Significant Improvement of Disease Signs and,Symptoms in Patients with Rheumatoid Arthritis 3New Data Confirms Significant Improvement of Disease Signs and,Symptoms in Patients with Rheumatoid Arthritis 4Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory,Compound, Shows Efficacy in Psoriasis 2
... a ubiquitous enzyme that catalyzes the ... also the specific protein that is ... (EMA) tests (Bio-Rad catalog number 29003 ... tests are highly sensitive and specific ...
We offer small and large pre-gelled Surface Electrodes suitable for EMG or EGG recordings....
We offer small and large pre-gelled Surface Electrodes suitable for EMG or EGG recordings....
We offer small and large pre-gelled Surface Electrodes suitable for EMG or EGG recordings....
Medicine Products: