Navigation Links
Breast Cancer's Spread Now Better Understood
Date:12/6/2009

Findings offer hope for future treatments targeting growth factor, researchers say

SUNDAY, Dec. 6 (HealthDay News) -- The spread of breast cancer cells from the main tumor to other parts of the body is controlled by a growth factor known as TGFb, which may prove a promising target for new drugs to prevent metastatic breast cancer, British researchers say.

Previous studies have shown that TGFb (transforming growth factor beta) regulates normal cell growth and movement. In this new study, a team from Cancer Research UK used an advanced microscopy and analysis technique to document the movement of cancer cells from primary breast tumor sites in mice.

The researchers found that single breast cancer cells broke away from the main tumor and entered the blood system when TGFb turned on messenger genes in the cancer cells and then turned them off.

When TGFb was inactive, clumps (but not single cells) of breast cancer cells broke away from the main tumor. Because these clumps can spread only through the lymphatic system, not through the blood, the spread of cancer was local, the study authors explained.

"The results helped us to find the set of genes that are behind the spread of breast cancer -- and that the genes need to be first turned on and then off in order for single cancer cells to be able to 'relocate,'" study author Erik Sahai said in a news release from Cancer Research UK.

He noted that in "a medium-sized tumor there could be a billion cells -- and only a small proportion might break away and spread. So it is like trying to find -- and understand -- a moving needle in a very big haystack."

The study, published in the October issue of the journal Nature Cell Biology, is scheduled to be presented Sunday at the annual meeting of the American Society for Cell Biology, held Dec. 5 to 9 in San Diego.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: American Society for Cell Biology, news release, Dec. 6, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. MRI finds breast cancer before it becomes dangerous
3. Pathway links inflammation, angiogenesis and breast cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Breast cancer prevention practices vary across Canada
6. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
7. Acrylamide Wont Raise Breast Cancer Risk
8. New link between estrogen and breast cancer
9. Hypnosis Eases Pain of Breast Cancer Surgery
10. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
11. Longaberger Expands Horizon of Hope Campaign to Build Support for American Cancer Societys Breast Cancer Initiatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 22, 2017  As the latest Obamacare repeal effort ... Cassidy (R-LA) and Lindsey Graham (R-SC) ... medical device industry is in an odd place.  The ... 2.3% excise tax on medical device sales passed along ... covered patients, increased visits and hospital customers with the ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017  PMD ... OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... strategic hub service that expedites and streamlines patient and ... Spiro PD 2.0, and wellness management services.  ... medical device used to measure lung function for a ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent ... as the number one company for hearing aids, ranking it ... fifteen other brands. ... Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, ...
Breaking Medicine Technology: