Navigation Links
Breast Cancer Vaccine Blasts Some Tumors

In animal studies, it eliminated aggressive growths

MONDAY, Sept. 15 (HealthDay News) -- An experimental breast cancer vaccine eliminated tumors in laboratory animals and may someday help prevent cancer recurrence or help treat women with treatment-resistant forms of breast cancer.

"The results were striking," said study author Dr. Wei-Zen Wei, a professor of immunology and microbiology at the Karmanos Cancer Center at Wayne State University. The research was published in the Sept. 15 issue of Cancer Research.

Wei's vaccine targets HER2-positive tumor cells. These breast cancers are often more aggressive than other types of cancer, are less responsive to treatment with hormones, and can become resistant to treatment.

On a cellular level, HER2 receptors promote normal cell growth, Wei explained. They are found in low amounts in normal breast cells, but HER2-positive breast cells can have many more receptors, and that in turn can promote the growth of an aggressive type of tumor.

Even therapies such as Herceptin (trastuzumab), designed to hook up with these receptors and destroy them, sometimes work only for a short period of time, after which patients develop a resistance, and the drug stops working.

Enter the study of Wei's vaccine, which includes "naked" DNA, genes that produce the HER2 receptor, and an immune system stimulant. When she delivered the vaccine into the leg muscles of mice with HER2-positive tumors, the gene made a huge supply of HER2 receptors that activated the immune system.

After the injection, "the body is making in this one location a lot of HER2," she said. The immune system kicks in and mounts an attack against the HER2-positive receptors, she found.

''None of them grew tumors," Wei said. That was true whether or not the tumor cells had grown drug-resistant or not.

The investigational vaccine, one of several under study for breast cancer, looks "potentially valuable," said Dr. Minetta Liu, director of translational breast cancer research at Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C.

"This [vaccine] is a little unique," she said. "It may help restore drug sensitivity to tumor cells." Of the research, she said: "It's valuable research, potentially groundbreaking."

"What they are doing is providing a different kind of immune response," added Dr. Bill Chambers, scientific program director for the American Cancer Society. Often a vaccine works by directly stimulating the production of antibodies, which then attack what's perceived as a foreign invader. "Instead of inducing the production of antibodies, it induces the development of cells that directly kill the tumor," Chambers said. "It's a very useful observation."

Much more research is needed to determine if the findings will bear out and apply to humans, Liu said.

More information

To learn more about cancer vaccines, visit the American Cancer Society.

SOURCES: Wei-Zen Wei, Ph.D., professor, immunology and microbiology, Karmanos Cancer Institute, Wayne State University, Detroit; Minetta Liu, M.D., assistant professor, medicine, and director, translational breast cancer research, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.; Bill Chambers, Ph.D., scientific program director, American Cancer Society, Atlanta; Sept. 15, 2008, Cancer Research

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Risk of breast cancer mutations underestimated for Asian women, Stanford study shows
2. Pennsylvania Breast Cancer Coalition Hosts Annual Conference
3. Breast cancer screening may lower mortality and disease burden in India
4. Eating fish while pregnant, longer breastfeeding, lead to better infant development
5. Formula Samples Hinder Breast-Feeding Efforts
6. Yoplait(R) Celebrates 10th Anniversary of Save Lids to Save Lives(R) and Sustained Commitment to Fight Against Breast Cancer
7. Drug Re-Sensitizes Breast Tumors to Treatment
8. Breast Cancer Drug Not Tied to Cognitive Decline: Study
9. Hospitals provide formula sample packs while medical organizations encourage breastfeeding
10. Komen Travels to Republican Convention to Raise Awareness of Breast Cancer Issues
11. Superbug breast infections controllable in nursing mothers, UT Southwestern researchers find
Post Your Comments:
Related Image:
Breast Cancer Vaccine Blasts Some Tumors
(Date:11/25/2015)... Ill. (PRWEB) , ... November 25, 2015 , ... ... and potentially more aggressive than those found on mammography, according to a study ... findings of additional cancers not seen on mammography may necessitate a change in ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... factory direct sauna parts and accessories. , Sauna accessories help improve the bather ... style and personality. From basic styles for the purist looking for simplicity in ...
(Date:11/25/2015)... , ... November 25, 2015 , ... According to an ... robot is being more and more widely heralded as a breakthrough for performing hernia ... method has over traditional laparoscopic surgery is that it can greatly reduce the pain ...
(Date:11/25/2015)... , ... November 25, 2015 , ... The McHenry County ... recent successful appellate decision obtained by Attorneys Francisco J. Botto and Alex C. Wimmer. ... Illinois Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , According to court documents, ...
(Date:11/25/2015)... ... 25, 2015 , ... Brillianteen, McGaw YMCA’s student-produced musical show, ... 65th Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions for this final ... has been a treasured tradition for numerous families in the Evanston community. Over ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Allergan plc (NYSE: AGN ), ... a start-up  biotechnology company focused on the development ... funded by the F-Prime Biomedical Research Initiative (FBRI), ... exclusive collaboration to support the discovery and development ... and Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... Ohio , Nov. 25, 2015 ... handle hazardous drug preparations (e.g. pharmacists, pharmacy technicians, ... and veterinary technicians). The chapter also covers all ... drugs (e.g., pharmacies, hospitals, other healthcare institutions, patient ... --> --> ...
(Date:11/25/2015)... 2015 Asia -based ... BioLight and the New Investors will make a direct ... a private placement. The financing will help IOPtima to ... used in the treatment of glaucoma, as well as ... IOPtimate™ system with the U.S. Food and Drug Administration, ...
Breaking Medicine Technology: