Navigation Links
Breast Cancer Vaccine Blasts Some Tumors

In animal studies, it eliminated aggressive growths

MONDAY, Sept. 15 (HealthDay News) -- An experimental breast cancer vaccine eliminated tumors in laboratory animals and may someday help prevent cancer recurrence or help treat women with treatment-resistant forms of breast cancer.

"The results were striking," said study author Dr. Wei-Zen Wei, a professor of immunology and microbiology at the Karmanos Cancer Center at Wayne State University. The research was published in the Sept. 15 issue of Cancer Research.

Wei's vaccine targets HER2-positive tumor cells. These breast cancers are often more aggressive than other types of cancer, are less responsive to treatment with hormones, and can become resistant to treatment.

On a cellular level, HER2 receptors promote normal cell growth, Wei explained. They are found in low amounts in normal breast cells, but HER2-positive breast cells can have many more receptors, and that in turn can promote the growth of an aggressive type of tumor.

Even therapies such as Herceptin (trastuzumab), designed to hook up with these receptors and destroy them, sometimes work only for a short period of time, after which patients develop a resistance, and the drug stops working.

Enter the study of Wei's vaccine, which includes "naked" DNA, genes that produce the HER2 receptor, and an immune system stimulant. When she delivered the vaccine into the leg muscles of mice with HER2-positive tumors, the gene made a huge supply of HER2 receptors that activated the immune system.

After the injection, "the body is making in this one location a lot of HER2," she said. The immune system kicks in and mounts an attack against the HER2-positive receptors, she found.

''None of them grew tumors," Wei said. That was true whether or not the tumor cells had grown drug-resistant or not.

The investigational vaccine, one of several under study for breast cancer, looks "potentially valuable," said Dr. Minetta Liu, director of translational breast cancer research at Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C.

"This [vaccine] is a little unique," she said. "It may help restore drug sensitivity to tumor cells." Of the research, she said: "It's valuable research, potentially groundbreaking."

"What they are doing is providing a different kind of immune response," added Dr. Bill Chambers, scientific program director for the American Cancer Society. Often a vaccine works by directly stimulating the production of antibodies, which then attack what's perceived as a foreign invader. "Instead of inducing the production of antibodies, it induces the development of cells that directly kill the tumor," Chambers said. "It's a very useful observation."

Much more research is needed to determine if the findings will bear out and apply to humans, Liu said.

More information

To learn more about cancer vaccines, visit the American Cancer Society.

SOURCES: Wei-Zen Wei, Ph.D., professor, immunology and microbiology, Karmanos Cancer Institute, Wayne State University, Detroit; Minetta Liu, M.D., assistant professor, medicine, and director, translational breast cancer research, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.; Bill Chambers, Ph.D., scientific program director, American Cancer Society, Atlanta; Sept. 15, 2008, Cancer Research

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Risk of breast cancer mutations underestimated for Asian women, Stanford study shows
2. Pennsylvania Breast Cancer Coalition Hosts Annual Conference
3. Breast cancer screening may lower mortality and disease burden in India
4. Eating fish while pregnant, longer breastfeeding, lead to better infant development
5. Formula Samples Hinder Breast-Feeding Efforts
6. Yoplait(R) Celebrates 10th Anniversary of Save Lids to Save Lives(R) and Sustained Commitment to Fight Against Breast Cancer
7. Drug Re-Sensitizes Breast Tumors to Treatment
8. Breast Cancer Drug Not Tied to Cognitive Decline: Study
9. Hospitals provide formula sample packs while medical organizations encourage breastfeeding
10. Komen Travels to Republican Convention to Raise Awareness of Breast Cancer Issues
11. Superbug breast infections controllable in nursing mothers, UT Southwestern researchers find
Post Your Comments:
Related Image:
Breast Cancer Vaccine Blasts Some Tumors
(Date:10/13/2015)... ... 13, 2015 , ... The added calories and sugar in an average trick-or-treat ... a parent to do? Registered dietitians from Retrofit , the leading corporate weight ... year. , “Halloween is a high-calorie holiday,” said Dara Aronow, Registered Dietitian, Retrofit. ...
(Date:10/13/2015)... ... 2015 , ... Vision Group Holdings, the largest LASIK provider in North America, ... The LASIK Vision Institute and TLC Laser Eye Centers, Vision Group Holdings has performed ... correction. , Global Laser Vision will continue to operate in San Diego as it ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... the United States, today announced the release of its limited edition holiday seasonal ... Cocktail Agua Fresca. All feature the unique flavor combinations and delicious taste Califia ...
(Date:10/13/2015)... ... 13, 2015 , ... ProText Kinetic Panel is a typography creation tool made ... can create energetic text animations in any layout without the use of keyframes. Using ... timeline and stylize the text. With intuitive on-screen controls, users can re-position and scale ...
(Date:10/13/2015)... Williamsport, PA (PRWEB) , ... October 13, 2015 , ... ... (SH) 2015 utility costs were 36 percent lower per square foot than in 2009. ... the actual cost of heating and cooling has decreased by eight percent. , ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015  The spine division ... leader in musculoskeletal healthcare, will showcase its portfolio of ... Spine Society (NASS) annual meeting, October 14-17, 2015, in ... also host two clinical events: "Supplemental MIS ... Presentation Wednesday, October 14 12:30 – 1 p.m. ...
(Date:10/13/2015)... N.J. , Oct. 13, 2015  ContraVir ... the "Company"), a biopharmaceutical company focused on the ... announced the closing of its previously announced underwritten ... stock and warrants to purchase up to 3,000,000 ... fixed combined price to the public of $3.00. ...
(Date:10/13/2015)... JOLLA, Calif. , Oct. 13, 2015  Human ... revolutionize the practice of medicine, announced today the launch ... clinical research project that has the potential to transform ... San Diego, CA , at HLI,s headquarters ... in 2016 in other US and International cities. ...
Breaking Medicine Technology: