Navigation Links
Breast Cancer Study Offers New Hope
Date:5/25/2010

Estrogen-lowering drugs before surgery let even high-risk women opt for lumpectomy

TUESDAY, May 25 (HealthDay News) --Giving certain breast cancer patients estrogen-lowering drugs before surgery enhances their chances of being able to choose a breast-conserving lumpectomy instead of a full mastectomy, new research suggests.

The observation was based on a national study launched at 118 hospitals across the United States. It focused on postmenopausal women who had been diagnosed with estrogen receptor-positive (ER+) breast cancer that was either at stage II or stage III -- that is, tumors that were around an inch or greater in size and might have spread to the lymph nodes under the arm.

The most common form of breast cancer, ER+ accounts for about three-quarters of all breast cancer cases in the United States, the authors noted.

The 352 women who participated were monitored for tumor growth before and after being placed on a 16-week regimen of aromatase inhibitors -- estrogen-lowering agents -- before any surgery. Estrogen stimulates the growth of ER+ tumors.

The women were classified into three groups as the study began: "marginal", meaning that the women were eligible for a lumpectomy to conserve the breast, but that it would be disfiguring or require several operations; "mastectomy-only", meaning a lumpectomy was not considered possible; and "inoperable", meaning that doctors believed that even a mastectomy would not completely remove the cancer.

After the four months of estrogen-lowering therapy, the research team found that 82 percent of those women in the marginal group were, in fact, able to undergo successful breast-conservation surgery.

More than half of those women who had been categorized as mastectomy-only patients were also able to go the lumpectomy route and experience a good outcome. And 75 percent of those thought to be inoperable altogether were able to have breast-conservation surgery.

The investigation was funded by the American College of Surgeons Oncology Group and led by Dr. Julie A. Margenthaler, an assistant professor of surgery and a breast surgeon at the Siteman Cancer Center at Washington University in St. Louis.

"Aromatase inhibitor therapy shrank the tumors in many of these women and improved surgical outcomes," study chair Dr. Matthey J. Ellis, a breast cancer specialist at Washington University and Barnes-Jewish Hospital, said in a news release. "These results will encourage a change in practice across the country so that more women can benefit from the currently underutilized approach of administering estrogen-lowering agents before surgery."

The findings are scheduled to be presented June 7 at the American Society of Clinical Oncology annual meeting, in Chicago.

More information

For more on surgical options for breast cancer, visit the U.S. National Cancer Institute.



--Alan Mozes



SOURCE: American Society of Clinical Oncology meeting, May 20, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. Carol Milgard Breast Center Awarded Highest Government Rating for Mammography Sites
5. Prolactin blocks oncogene associated with poor prognosis in breast cancer
6. Definitive study confirms chemo benefit in postmenopausal breast cancer
7. Adding Chemo to Tamoxifen Helps Some Breast Cancer Patients
8. Major New Study Finds Soyfoods Safe and Beneficial for Women With Breast Cancer
9. Bone Drugs May Beat Back Breast Cancer
10. California Breast Cancer Survivors and Advocates Call on State to Nix Screening Cuts
11. Alcohol consumption may increase breast cancer recurrence risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... , ... May 26, 2016 , ... ... intellectual property (IP) to its specialty academic programs. , Answering to the increasing ... existing certificate programs in health law, and environmental and land use law. , ...
(Date:5/26/2016)... ... 2016 , ... Cardiac arrhythmia is a common complication following ... survival, reports a team of UPMC researchers in the largest study of its ... Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead to better ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel will ... Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public ... Retina Group of New York , is a Board Certified ophthalmologist who ...
(Date:5/26/2016)... ... 2016 , ... Leadership of Life Science Logistics (LSL), a ... earned its ISO 13485 certification, indicating the company’s quality control system for medical ... associated with ISO quality standard 13485. , BSI Group America, Inc., a ...
(Date:5/26/2016)... ... May 26, 2016 , ... Nike Yoga Camps ... from daily practices, arts & crafts, discussions, and games all geared towards enhancing ... Evans have combined backgrounds in kids’ yoga, collegiate sport yoga instruction, and global ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25,2016 FDA ... near-infrared Cellvizio platform for urological and surgical applications ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... milestone in the US with the 12 th ... Drug Administration (FDA). This new FDA clearance covers ...
(Date:5/25/2016)... , Germany and GERMANTOWN, ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... licensing and co-development agreement with Therawis Diagnostics GmbH to develop ... be to develop and market PITX2 as a marker to ... high-risk breast cancer patients. "We are pleased to ...
(Date:5/25/2016)... -- According to market research "Global Insulin ... Forecast to 2022 - Industry Insights by Type (Insulin ... P&S Market Research, the global insulin delivery device market ... is expected to grow at a CAGR of 6.6% ... is expected to witness the fastest growth at a ...
Breaking Medicine Technology: