Navigation Links
Breast Cancer Radiation Therapy Works in Fewer, But Higher Doses
Date:3/18/2008

The regimen is less challenging for patients but equally effective in preventing relapse, British studies find

TUESDAY, March 18 (HealthDay News) -- The use of radiation therapy in fewer, but higher doses appears to be just as effective as conventional doses for women recovering from breast cancer, British researchers report.

Because fewer treatments are needed, the overall amount of radiation the patient receives is actually less, though treatment outcomes remain the same or better, according to two British trials appearing this week in the April edition of the journal Lancet Oncology and an upcoming edition of The Lancet.

The studies, led by researchers at the Institute of Cancer Research, in Sutton, support what other trials have already shown and what doctors have noted in practice settings, experts said.

"These two studies confirm work done in the U.S.," said Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, LA. "Today, there are a whole bunch of techniques to give shorter courses of radiation."

According to background information in the studies, the international standard radiation schedule for breast cancer treatment involves a high total dose delivered in 25 small daily doses or fractions. But this approach, which reduces the risk of local cancer relapse by about 70 percent, requires a huge investment of time and effort on the part of the patient.

"One of the biggest problems in radiation therapy is just the sheer amount of time it takes for women to receive treatment," Brooks said. "In the U.S., traditionally, it's about six weeks of treatment. When many women live 50 miles from a radiation center, that's a 100-mile trip each day, five days a week. That's an enormous amount of time and effort to have radiation."

In the first trial, known as START A, 2,236 women with early-stage breast cancer were randomly assigned to receive the conventional dose of radiotherapy or one of two regimens both involving fewer but larger fractions of radiation.

All treatments were given over five weeks, essentially the standard amount of time for conventional radiotherapy.

After a median follow-up of about five years, the rate of tumor recurrence was about equivalent in the two groups. There also seemed to be fewer adverse effects in the groups receiving the lower total dosage.

The second trial, known as START B, involved 2,215 women, again with early breast cancer, who were randomly assigned after surgery to receive the conventional, higher dose of radiation or to receive fewer, larger fractions. The conventional arm received their therapy over five weeks while the second group received theirs over three weeks.

This time, after a median follow-up of six years, the rate of tumor recurrence was 2.2 percent in the group receiving a smaller total dose of radiation, versus 3.3 percent in the conventional-treatment arm.

More information

For more on breast cancer treatment, visit the U.S. National Cancer Institute.



SOURCES: Jay Brooks, M.D., chairman of hematology/oncology, Ochsner Health System, Baton Rouge, La; April 2008 Lancet Oncology; online The Lancet


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. MRI finds breast cancer before it becomes dangerous
3. Pathway links inflammation, angiogenesis and breast cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Breast cancer prevention practices vary across Canada
6. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
7. Acrylamide Wont Raise Breast Cancer Risk
8. New link between estrogen and breast cancer
9. Hypnosis Eases Pain of Breast Cancer Surgery
10. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
11. Longaberger Expands Horizon of Hope Campaign to Build Support for American Cancer Societys Breast Cancer Initiatives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast Cancer Radiation Therapy  Works in Fewer,  But Higher Doses
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: